http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lanthanitin: A Chiral Nanoball Encapsulating 18 Lanthanum Ions by Ferritin-Like Assembly
Jeong, Kyung Seok,Kim, Young Shin,Kim, Yun Ju,Lee, Eunsung,Yoon, Ji Hye,Park, Won Hwa,Park, Young Woo,Jeon, Seung-Joon,Kim, Zee Hwan,Kim, Jaheon,Jeong, Nakcheol WILEY-VCH Verlag 2006 Angewandte Chemie Vol.45 No.48
<B>Graphic Abstract</B> <P>A chiral supramolecule, obtained by self-assembly of 24 chiral ditopic carboxylate ligands, 18 La ions, and two carbonate anions, has been dubbed lanthanitin because of its structural resemblance to ferritin. The picture shows the molecular structure of one enantiomer of lanthanitin. Color code: La blue, carbonate C green, C gray, O red; H omitted. <img src='wiley_img/14337851-2006-45-48-ANIE200603622-content.gif' alt='wiley_img/14337851-2006-45-48-ANIE200603622-content'> </P>
Asymmetric catalytic reactions by NbO-type chiral metal–organic frameworks
Jeong, Kyung Seok,Go, Yong Bok,Shin, Sung Min,Lee, Suk Joong,Kim, Jaheon,Yaghi, Omar M.,Jeong, Nakcheol Royal Society of Chemistry 2011 Chemical science Vol.2 No.5
<P>Chiral metal–organic frameworks (MOFs) constitute a unique class of multifunctional hybrid materials and are envisioned as a versatile tool for various enantioselective applications, including the separation of optical isomers and the promotion of catalytic enantioselective reactions. Despite some pioneering works on catalytic enantioselective reactions promoted by chiral MOFs, there is still a need for practical catalysts and many fundamental issues must be answered; such as pin-pointing the site of the reaction and expedition of the reaction rate to the level of that in homogeneous media. We have designed and synthesized a chiral metal–organic framework, (<I>S</I>)-KUMOF-1 (Cu<SUB>2</SUB>(<I>S</I>)-<B>1</B>)<SUB>2</SUB>(H<SUB>2</SUB>O)<SUB>2</SUB>, <B>1</B> = 2,2′-dihydroxy-6,6′-dimethyl(1,1′-biphenyl)-4,4′-dicarboxylate) of which a non-interpenetrating NbO type framework provides a spacious pore (2 × 2 × 2 nm<SUP>3</SUP>) and is equipped with potential catalytic sites exposed into the pore. Since the functional group on the organic links, biphenols in this MOF, can be modified further on demand, this MOF can serve as a platform for new heterogeneous catalysis. Two reactions, the carbonyl-ene reaction with modified MOF after replacement of the protons on biphenol on the organic links with Zn(<SMALL>II</SMALL>) and the hetero-Diels–Alder reaction with Ti(<SMALL>IV</SMALL>), respectively, were studied. In this manoeuver, we observed that the reaction occurs entirely inside the pores and the reaction rate of the heterogeneous reaction by this specific MOF is comparable to that of its homogeneous counterpart. In addition, it is also observed that the enantioselectivities are significantly improved by extra steric bias provided from the frames of the MOF. These observations reinforce the legitimacy of the strategy of using a chiral MOF as a highly enantioselective heterogeneous catalyst.</P> <P>Graphic Abstract</P><P>A newly obtained chiral MOF, (<I>S</I>)-KUMOF-1, was employed as a heterogeneous asymmetric catalyst/reagent, with which conclusive evidence for the reaction inside the pores is obtained. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0sc00582g'> </P>
Exploration of Novel 2-Alkylimino-1,3-thiazolines: T-Type Calcium Channel Inhibitory Activity
Han, Minsoo,Nam, Kee Dal,Shin, Dongyun,Jeong, Nakcheol,Hahn, Hoh-Gyu American Chemical Society 2010 Journal of combinatorial chemistry Vol.12 No.4
<P>We have developed combinatorial libraries of new 2-alkylimino-1,3-thiazolines with four diversity points, consisting of more than 500 compounds, in a parallel synthetic fashion. The synthetic strategy was based on the construction of a large library aimed at the discovery of new compounds with T-type calcium channel inhibitory activity through structure modifications of hit compound <B>2</B>. The syntheses of the compounds of Chemset A with four diversity points were accomplished by the condensation of thioureas <B>5</B> with α-haloketones <B>6</B>{<I>1−66</I>} having two diversity points each. A library of phthalimidyl 1,3-thiazolines <B>24</B> was synthesized to provide Chemset B, which allowed the introduction of other diversity points through the nucleophilic character of the amino nitrogen. A sublibrary, Chemset C, was constructed from the libraries of Chemset A and Chemset B by functionalization of the C-4 position of the 1,3-thiazoline ring. The products containing ester or acid groups at the C-4 position of the 1,3-thiazoline ring were used in amide synthesis to give a new sublibrary within Chemset C. Deprotection of the phthalimidyl moiety of <B>24</B> followed by the reaction with benzoyl chloride gave the corresponding sublibrary in Chemset C. Another sublibrary which includes secondary amino derivatives was obtained by reduction of the amide moiety or reductive amination of <B>23</B> with phenyl aldehyde. The selected compounds from the generated libraries were evaluated with respect to inhibition of T-type calcium channels, where some of them have exhibited promising activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jcchff/2010/jcchff.2010.12.issue-4/cc100041m/production/images/medium/cc-2010-00041m_0022.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P>
Homochiral 3D metal–organic frameworks from chiral 1D rods: 6-way helical packing
Shin, Sung Min,Moon, Dohyun,Jeong, Kyung Seok,Kim, Jaheon,Thallapally, Praveen K.,Jeong, Nakcheol Royal Society of Chemistry 2011 Chemical communications Vol.47 No.33
<P>The chiral 3D MOFs resulted from the packing of chiral 1D SBBs were studied. It was demonstrated that the final packing pattern is sensitively dependent on the dimension of SBBs. In addition, we were able to identify a new plywood-like network from ligand 2H<SUB>2</SUB> exhibiting <I>an unprecedented six-way chiral helical packing motif</I>, which extends the list of invariant rod packings.</P> <P>Graphic Abstract</P><P>A new plywood-like 3D metal–organic framework from ligand 2H<SUB>2</SUB> exhibiting <I>an unprecedented six-way chiral helical packing motif via a chiral 1D SBB</I> was identified. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc12908b'> </P>
A Total Synthesis of (-)-α-Kainic Acid By the Pauson-Khand Reaction
Yoo, Sung-eun,Lee, Sang-Hee,Jeong, Nakcheol,Cho, Inho 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-
A total synthetic route to (-)-α-kainic acid has been developed based on the Pauson-Khand reaction as a key reaction for the construction of the bicyclo ring system.
Kinetic Resolutions by Enantioselective Pauson–Khand-Type Reaction
Kim, Dong Eun,Kwak, Jaesung,Kim, In Su,Jeong, Nakcheol WILEY-VCH Verlag 2009 Advanced Synthesis & Catalysis Vol. No.
<P>A kinetic resolution of 1-arylallyl propargyl ethers by enantioselective Pauson–Khand-type reaction catalysts was successfully carried out. While cationic rhodium(I) with a BINAP-based ligand having an electron-deficient phosphine is the choice for the slow reacting substrates, neutral iridium(I) with a BINAP-based ligand possessing an electron-rich phosphine provided excellent results for the more reactive substrates.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/16154150-2009-351-1-2-ADSC200800657-content.gif' alt='wiley_img/16154150-2009-351-1-2-ADSC200800657-content'> </P>
Assessing the guest-accessible volume in MOFs using two-photon fluorescence microscopy
Shin, Sung Min,Lee, Mi Sun,Han, Ji Hee,Jeong, Nakcheol The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.3
<P>The assessment of guest-accessible volume in MOFs can be reliably done by using two-photon confocal fluorescence microscopy (TPM) with a tool-box of dyes with a wide range of sizes. It would be applicable to any porous materials, whose single-crystal structures are not available, or non-crystalline materials.</P> <P>Graphic Abstract</P><P>For determining the guest-accessible volume of porous materials by eye, especially for MOFs in this case, two-photon fluorescence microscopy with various dyes was successfully employed. It would be applicable to any porous materials, whose single-crystal structure is not available, or non-crystalline materials. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc44008g'> </P>
Lee, Ju-Hyeon,El-Damasy, Ashraf K.,Seo, Seon Hee,Gadhe, Changdev G.,Pae, Ae Nim,Jeong, Nakcheol,Hong, Soon-Sun,Keum, Gyochang Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.21
<P><B>Abstract</B></P> <P>Two new series of 5-subtituted and 5,6-disubstituted pyrrolo[2,3-<I>d</I>]pyrimidine octamides (<B>4a</B>–<B>o</B> and <B>6a</B>–<B>g</B>) and their corresponding free amines <B>5a</B>–<B>m</B> and <B>7a</B>–<B>g</B> have been synthesized and biologically evaluated for their antiproliferative activity against three human cancer cell lines. The 5,6-disubstituted octamides <B>6d</B>–<B>g</B> as well as the amine derivative <B>7b</B> have shown the best anticancer activity with single digit micromolar GI<SUB>50</SUB> values over the tested cancer cells, and low cytotoxic effects (GI<SUB>50</SUB> > 10.0 µM) against HFF-1 normal cell. A structure activity relationship (SAR) study has been established and disclosed that terminal octamide moiety at C2 as well as disubstitution with fluorobenzyl piperazines at C5 and C6 of pyrrolo[2,3-<I>d</I>]pyrimidine are the key structural features prerequisite for best antiproliferative activity. Moreover, the most active member <B>6f</B> was tested for its antiproliferative activity over a panel of 60 cancer cell lines at NCI, and exhibited distinct broad spectrum anticancer activity with submicromolar GI<SUB>50</SUB> and TGI values over multiple cancer cells. Kinase profile of compound <B>6f</B> over 53 oncogenic kinases at 10 µM concentration showed its highly selective inhibitory activity towards FGFR4, Tie2 and TrkA kinases. The observed activity of <B>6f</B> against TrkA (IC<SUB>50</SUB> = 2.25 µM), FGFR4 (IC<SUB>50</SUB> = 6.71 µM) and Tie2 (IC<SUB>50</SUB> = 6.84 µM) was explained by molecular docking study, which also proposed that <B>6f</B> may be a type III kinase inhibitor, binding to an allosteric site rather than kinase hinge region. Overall, compound <B>6f</B> may serve as a promising anticancer lead compound that could be further optimized for development of potent anticancer agents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis and <I>in vitro</I> antiproliferative activities of new pyrrolo[2,3-<I>d</I>]pyrimidines are reported. </LI> <LI> Compounds <B>6d–g</B> exerted single digit micromolar GI<SUB>50</SUB> values over the tested cancer cell lines. </LI> <LI> Compound <B>6f</B> has selective inhibitory activity towards FGFR4, Tie2 and TrkA kinases. </LI> <LI> Compound <B>6f</B> may be a type III allosteric kinase inhibitor. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>