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Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism.
Baik, Myunggi,Yu, Ji Hoon,Hennighausen, Lothar New York Academy of Sciences 2011 Annals of the New York Academy of Sciences Vol.1229 No.1
<P>The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.</P>
BAIK, MYUNGGI,HARROLD, ROBERT L.,CHOI, CHANG B.,SLANGER, WILLIAM D.,SUNG, CHANG K.,PARK, CHUNG S. 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-
Effects of testosterone and energy restriction (30%) on enzyme activity and mRNA level of ornithine decarboxylase (ODC) were studied in 19-wkold female Sprague-Dawley rats. Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts in the kidney. Energy restriction also increased renal ODC activity. Further, the 56% increase in ODC enzyme activity observed in the testosterone-implanted, energy-restricted group was greater than the 24% increase in the placebo-implanted, energy-restricted group. No changes in renal ODC mRNA levels were observed in the energyrestricted groups. These observations suggest that translational or post-translational mechanism(s) are in-volved in the greater renal OCD activity in energy-restricted rats. J. Nutr. 122: 1056-1061, 1992.
Effects of Castration on Expression of Lipid Metabolism Genes in the Liver of Korean Cattle
Baik, Myunggi,Nguyen, Trang Hoa,Jeong, Jin Young,Piao, Min Yu,Kang, Hyeok Joong Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.1
Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in the liver following castration. To understand changes in lipid metabolism following castration, hepatic expression levels of lipid metabolism genes were compared between Korean bulls and steers. Steers had higher (p<0.001) hepatic lipids contents and higher (p<0.01) mRNA levels of lipogenic acetyl-CoA carboxylase. This differential gene expression may, in part, contribute to increased hepatic lipid content following the castration of bulls. However, we found no differences in the hepatic expression levels of genes related to triglyceride synthesis (mitochondrial glycerol-3-phosphate acyltransferase, diacylglycerol O-acyltransferase 1 and 2) and fatty acid (FA) oxidation (carnitine palmitoyltransferase 1A, C-4 to C-12 straight chain acyl-CoA dehydrogenase, very long chain acyl-CoA dehydrogenase) between bulls and steers. No differences in gene expression for very-low-density lipoprotein (VLDL) secretion, including apolipoprotein B mRNA and microsomal triglyceride transfer protein (MTTP) protein, were observed in the liver although MTTP mRNA levels were higher in steers compared to bulls. In conclusion, FA synthesis may contribute to increased hepatic lipid deposition in steers following castration. However, hepatic lipid metabolism, including triglyceride synthesis, FA oxidation, and VLDL secretion, was not significantly altered by castration. Our results suggest that hepatic lipid metabolism does not significantly contribute to increased body fat deposition in steers following castration.
Baik, Myunggi,Kim, Jangseon,Piao, Min Yu,Kang, Hyeok Joong,Park, Seung Ju,Na, Sang Weon,Ahn, Sung-Hoon,Lee, Jae-Hyuk Elsevier 2017 The Journal of nutritional biochemistry Vol.39 No.-
<P>Signal transducers and activators of transcription 5 (STAT5) mediates growth hormone signals, which may control hepatic cholesterol uptake and bile acid metabolism. Deregulation of liver cholesterol homeostasis and bile acid metabolism may cause liver damage and cholesterol gallstone development. The purpose of this study was to understand the role of local STAT5 signaling in cholesterol and bile acid metabolism using liver-specific STAT5 knock-out (STAT5 LKO) mice on a normal diet and a cholesterol- and bile acid-containing lithogenic diet. STAT5 LKO mice showed significant down-regulation of STAT5 and insulin-like growth factor-1 genes. STATS gene deletion had a minor effect on cholesterol metabolism, as evidenced by a minor change in circulating cholesterol levels and no changes in expression of hepatic low-density lipoprotein receptor and cholesterol synthesis genes in STAT5 LKO mice. In contrast, bile acid synthesis and uptake genes were profoundly down-regulated and bile acid detoxification genes were up-regulated in STATS LKO mice. In STAT5 fl/fl mice, a lithogenic diet induced liver damage, as evidenced by moderate increases in liver ballooning, inflammation and fibrosis. However, STATS deletion ameliorated the degree of liver damage induced by the lithogenic diet. In STATS LKO mice, a lithogenic diet did not alter the incidence or severity of cholesterol gallstones. In conclusion, local STATS signaling does not have a significant role in cholesterol metabolism. In contrast, hepatic STAT5 signaling has significant roles in regulating transcription of genes for synthesis, transport and detoxification of bile acids, but it has only a minor role in bile acid metabolism. (C) 2016 Elsevier Inc. All rights reserved.</P>
Hepatic transcriptional changes in critical genes for gluconeogenesis following castration of bulls
Fassah, Dilla Mareistia,Jeong, Jin Young,Baik, Myunggi Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.4
Objective: This study was performed to understand transcriptional changes in the genes involved in gluconeogenesis and glycolysis pathways following castration of bulls. Methods: Twenty Korean bulls were weaned at average 3 months of age, and castrated at 6 months. Liver tissues were collected from bulls (n = 10) and steers (n = 10) of Korean cattle, and hepatic gene expression levels were measured using quantitative real-time polymerase chain reaction. We examined hepatic transcription levels of genes encoding enzymes for irreversible reactions in both gluconeogenesis and glycolysis as well as genes encoding enzymes for the utilization of several glucogenic substrates. Correlations between hepatic gene expression and carcass characteristics were performed to understand their associations. Results: Castration increased the mRNA (3.6 fold; p<0.01) and protein levels (1.4 fold; p<0.05) of pyruvate carboxylase and mitochondrial phosphoenolpyruvate carboxykinase genes (1.7 fold; p<0.05). Hepatic mRNA levels of genes encoding the glycolysis enzymes were not changed by castration. Castration increased mRNA levels of both lactate dehydrogenase A (1.5 fold; p<0.05) and lactate dehydrogenase B (2.2 fold; p<0.01) genes for lactate utilization. Castration increased mRNA levels of glycerol kinase (2.7 fold; p<0.05) and glycerol-3-phosphate dehydrogenase 1 (1.5 fold; p<0.05) genes for glycerol utilization. Castration also increased mRNA levels of propionyl-CoA carboxylase beta (mitochondrial) (3.5 fold; p<0.01) and acyl-CoA synthetase short chain family member 3 (1.3 fold; p = 0.06) genes for propionate incorporation. Conclusion: Castration increases transcription levels of critical genes coding for enzymes involved in irreversible gluconeogenesis reactions from pyruvate to glucose and enzymes responsible for incorporation of glucogenic substrates including lactate, glycerol, and propionate. Hepatic gluconeogenic gene expression levels were associated with intramuscular fat deposition.
EGF Inhibits Expression of WDNM1 and Sulfated Glycoprotein-2 Genes in Mammary Epithelial Cells
Lee, Mijoung,Hwang, Intaek,Choi, Yunjaie,Paik, Sanggi,Lee, Hwanghee Blaise,Baik, Myunggi 충남대학교 생물공학연구소 1998 생물공학연구지 Vol.6 No.-
We have previously shown that expressions of ferritin heavy chain (FHC), WDNM1, and sulfated glycoprotein-2(SGP-2)genes are induced at an livolution stage of mammary gland. Here we studied the effect of lactogenic hormones and EGF on the expression of involution-induced genes in HC11 mammary epithelial cells. Insulin, dexamethasone, prolactin, and its combinations did not affect expression of the genes. When cells were cultured in growth medium containing EGF, expression of WDNM1 and SGP-2 genes was strongly inhibited in a dose- and time- dependent manner, whereas expression of FHC gene was not influenced by EGF. Results demonstrate that EGF inhibits expression of WDNM1 and SGP-2 genes in mammary epithelial cells. ⓒ 1997 Academic Press
Park, Seung Ju,Kang, Hyeok Joong,Na, Sangweon,Lee, Seung Hwan,Baik, Myunggi Elsevier 2018 Meat science Vol.136 No.-
<P>This study was performed to compare expression of genes for extracellular matrix (ECM) components, ECM degrading factors, and integrin subunits in the longissimus thoracis (LT) between bulls and steers. Steers had lower (P < 0.05) ECM component collagen type 1 alpha 1 and collagen type 3 alpha 1 mRNA levels than did bulls, but they had higher (P < 0.05) thrombospondin 1 mRNA and protein levels. Steers had higher (P < 0.01) matrix metalloproteinase (MMP) 9 mRNA levels than did bulls. Steers had higher (P < 0.05) integrin alpha 5 mRNA levels but lower (P < 0.05) integrin beta 6 mRNA and protein levels; however, expression levels of several other integrin subunits were not different between steers and bulls. MMP9 mRNA levels were positively correlated (P < 0.05) with intramuscular fat content in bull group. In conclusion, these results demonstrate that castration has moderate effects on expression of ECM components, ECM degrading factors, and integrin subunit genes in the LT.</P>