Fibroblast growth factor receptor 3‐mediated reactivation of ERK signaling promotes head and neck squamous cancer cell insensitivity to MEK inhibition

Ban, Myung Jin,Byeon, Hyung Kwon,Yang, Yeon Ju,An, Sojung,Kim, Jae Wook,Kim, Ji‐,Hoon,Kim, Da Hee,Yang, Jaemoon,Kee, Hyunjung,Koh, Yoon Woo John Wiley and Sons Inc. 2018 Cancer Science Vol.109 No.12

<P>Recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) has been a longstanding challenge for head and neck oncologists, and current treatments still have limited efficacy. ERK is aberrantly overexpressed and activated in HNSCC. Herein, we aimed to investigate the cause of the limited therapeutic effect of selumetinib, a selective inhibitor of MEK in HNSCC, as MEK/ERK reactivation inevitably occurs. We assessed the effects of combining selumetinib with fibroblast growth factor receptor 3 (FGFR3) inhibitor (PD173074) on tumor growth. Selumetinib transiently inhibited MAPK signaling and reactivated ERK signaling in HNSCC cells. Rebound in the ERK and Akt pathways in HNSCC cells was accompanied by increased FGFR3 signaling after selumetinib treatment. Feedback activation of FGFR3 was a result of autocrine secretion of the FGF2 ligand. The FGFR3 inhibitor PD173074 prevented MAPK rebound and sensitized the response of HNSCC cells to selumetinib. These results provided rational therapeutic strategies for clinical studies of this subtype of patients that show a poor prognosis with selumetinib. Our data provide a rationale for combining a MEK inhibitor with inhibitors of feedback activation of FGFR3 signaling in HNSCC cells. ERK rebound as a result of the upregulation of FGFR3 and the ligand FGF2 diminished the antitumor effects of selumetinib, which was overcome by combination treatment with the FGFR3 inhibitor.</P>

경부전이를 동반하여 이하선에 발생한 기저세포선암 1예

반명진(Myung Jin Ban),정혜연 (Hae Yoen Jung),홍현준(Hyun Jun Hong),변형권(Hyung Kwon Byeon),김원식(Won Shik Kim),박재홍(Jae Hong Park) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.1

Basal cell adenocarcinoma is a extremely rare low grade malignancy of the salivary gland. It is composed of ba-saloid cells with dark cell, light cells and pale cytoplasm which shows infiltrative growth pattern into adjacent glandular parenchyme. The pathophysiology of basal cell adenocarcinoma is not well known. First hypothesis is a malignant transformation of the monomorphic adenoma and second one is a de novo origin. Metastasis to the re-gional lymph nodes is rare. Recently, we have experienced a case of basal cell adenocarcinoma with neck metasta- sis after previous superficial parotidectomy. For this reason we report this rare case discussed with references.

악하선 공간에 생긴 동정맥 기형의 후이개 내시경 접근법을 이용한 절제술 1례

반명진(Myung Jin Ban),이치규(Chi Kyou Lee),이지혜(Ji Hye Lee),박재홍(Jae Hong Park) 대한두경부종양학회 2016 대한두경부 종양학회지 Vol.32 No.1

A 54-year-old female presented with a 4cm sized painless, submandibular gland area mass. Vascular lesion was suspected in computed tomography scan. Surgical excision was performed via retroauricular approach for its excellent cosmetic outcome. The vascular mass with peripheral focal calcification was clearly resected without complication such as bleeding or neural damage. Histopathological examination of the specimen revealed an arterio-venous malformation(AVM) with abnormal communications between arteries and veins without the normal inter-vening capillary bed. We report a successful excision of AVM in the submandibular space via retroauricular approach.

Parametric Characterization of Self-Heating in Depletion-Type Si Micro-Ring Modulators

Myung Jin Shin,Yoojin Ban,Byung-Min Yu,Jinsoo Rhim,Zimmermann, Lars,Woo-Young Choi IEEE 2016 IEEE journal on selected topics in quantum electro Vol.22 No.6

<P>The influence of self-heating on the static transmission characteristics of depletion-type Si micro-ring modulators (MRMs) is investigated. Self-heating, caused by free-carrier absorption of the input light inside the doped ring waveguide, increases the effective refractive index of the ring waveguide and results in the red-shifted resonance wavelength. This phenomenon is modeled based on the coupled-mode equation with a newly-introduced self-heating coefficient R. The accuracy of our model is confirmed by measurement. In addition, dependence of R on device size and doping concentration is experimentally investigated and the resulting dependence is explained.</P>

Inflexinol, a NF-kB inhibitor prevents colon cancer cell growth via induction of apoptotic cell death

HONG Jin Tae,BAN Jeong Ok,LEE Seung Ho,CHOI Myung Suk,KIM Sun M,HWANG Bang Yeon,RO Jai Seup,YOO Hwan Soo,OH Ki Wan 大韓藥學會 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2

콘크리트 매설관의 동적응답해석에 대한 곡선적합식의 개발

정진호 ( Jin Ho Jeong ),김성반 ( Sung Ban Kim ),안명석 ( Myung Seok Ahn ) 대한화약발파공학회 2006 화약발파 Vol.24 No.1

경구강 악하선 절제술 후 발생한 반대측 설하신경 마비 1례

반원우(Won Woo Ban),반명진(Myung Jin Ban),이치규(Chi Kyou Lee),박재홍(Jae Hong Park) 대한두경부종양학회 2016 대한두경부 종양학회지 Vol.32 No.1

The resection of submandibular gland is usually performed via trascervical, transoral approach. The authors suspected the stenosis of Wharton's duct of 54 years old female patient after transoral removal of submandibular stone and the resection of submandibular gland was decided. Because of cosmetic need, the resection was per-formed transorally. The operation was completed successfully without any injury to unilateral lingual nerve or hypoglossal nerve but contralateral paralysis of hypoglossal nerve was seen. In our knowledge, this is the first report of contralateral hypoglossal nerve palsy during transoral resection of submandibular gland.

The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study

Hyeji Kwon,Song Hwa Chae,Hyo Jin Jung,Hyeon Min Shin,O-Hyun Ban,Jungwoo Yang,Jung Ha Kim,Ji Eun Jeong,Hae Myung Jeon,Yong Won Kang,Chan Kum Park,Daeyoun David Won,Jong Kyun Lee 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.5

Purpose: Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this study was to evaluate change in microbiota composition after-probiotics supplementation and assessed the efficacy of probiotics in improving quality of life (QOL) in postoperative cancer patients. Methods: Stool samples were collected from 30 cancer patients from February to October 2020 before (group I) and after (group II) 8 weeks of probiotics supplementation. We performed 16S ribosomal RNA gene sequencing to evaluate differences in gut microbiota between groups by comparing gut microbiota diversity, overall composition, and taxonomic signature abundance. The health-related QOL was evaluated through the EORTC Quality of life Questionnaire Core 30 questionnaire. Results: Statistically significant differences were noted in group II; increase of Shannon and Simpson index (P = 0.004 and P = 0.001), decrease of Bacteroidetes and Fusobacteria at the phylum level (P = 0.032 and P = 0.014, retrospectively), increased of beneficial bacteria such as Weissella (0.096% vs. 0.361%, P < 0.004), Lactococcus (0.023% vs. 0.16%, P < 0.001), and Catenibacterium (0.0% vs. 0.005%, P < 0.042) at the genus level. There was a significant improvement in sleep disturbance (P = 0.039) in group II. Conclusion: Gut microbiota in cancer patients can be manipulated by specific probiotic strains, result in an altered microbiota. Microbiota modulation by probiotics can be considered as part of a supplement that helps to increase gut microbiota diversity and improve QOL in cancer patients after surgery.

Traction force microscopy for understanding cellular mechanotransduction

( Sung Sik Hur ),( Ji Hoon Jeong ),( Myung Jin Ban ),( Jae Hong Park ),( Jeong Kyo Yoon ),( Yongsung Hwang ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.2

Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors. Substantial progresses have been made in the field of mechanobiology towards novel methods to understand how cells are able to sense and adapt to these mechanical forces over the years. To address these issues, this review will discuss recent advancements of traction force microscopy (TFM), intracellular force microscopy (IFM), and monolayer stress microscopy (MSM) to measure multiple aspects of cellular forces exerted by cells at cell-ECM and cell-cell junctional intracellular interfaces. We will also highlight how these methods can elucidate the roles of mechanical forces at interfaces of cell-cell/cell-ECM in regulating various cellular functions. [BMB Reports 2020; 53(2): 74-81]

제2열 새열 낭종으로 오인되었던 편도암의 낭성 경부 임파절 전이 1예

박승범(Seung Bum Park),노민호(Minh Ho Noh),반원우(Won Woo Ban),반명진(Myung Jin Ban),박재홍(Jae Hong Park) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.2

Cystic lymph node metastasis of head and neck squamous cell carcinoma(HNSCC) which presumed to be mainly originated from oropharynx including Waldeyer’s ring may present as a benign cystic mass on lateral neck such as branchial cleft cyst. Branchial cleft cyst is one of the most common lateral neck cystic mass which may result in regional infection or lymph adenopathy. Many of previously reported literatures showed the incidence of cystic lymph node metastasis from oropharynx including Waldeyer’s ring. Preoperative imaging studies and fine needle aspiration cytology cannot provide the accurate results until excision of cystic mass for the diagnostic or therapeutic purpose. Recently, we experienced the rare case of cystic lymph node metastasis from ipsilateral tonsil, which mim-icked infected 2nd branchial cleft cyst. Thus, we reported our experience with presentation of case and review of literatures.