Evolutionary Programming for Designing Independent Cells

문치웅,김장형,이유경 濟州大學校 産業技術硏究所 1997 산업기술연구소논문집 Vol.8 No.1

In this paper, an evolutionary programming approach is proposed for the designing independent cells in cellular manufacturing with alternative process plans and machine duplication consideration. Several manufacturing parameters such as production volume, machine capacity, processing time, number of cells and cell size are considered in the process. The model is formulated as a 0-1 integer programming and solved using genetic algorithm. It determines the machine cells, part families and process plan for each part simultaneously.

유연성이 있는 부품의 조립작업에 대한 연구

문창렬(Chang You1 Moon),조형석(Hyung Suck Cho) 제어로봇시스템학회 1992 제어로봇시스템학회 국내학술대회 논문집 Vol.1 No.1

림프질 전이가 있는 하인두암과 하부식도암의 진단에 활용된 내시경초음파 유도하 Trucut 생검 1예

광명옥,이정환,문정섭,김유선,류수형,총배천,김형훈,김현태 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

The incidence of double primary cancer is about 10% in all kinds of cancers. Double primary cancer is usually accompanied by gastrointestinal cancer. Esophageal cancer is supposed to be frequently accompanied by squamous cell carcinoma of the head and neck or the upper respiratory tract, because of such common carcinogens as smoking and alcohol ingestion. Esophageal cancer and hypopharyngeal cancer are usually diagnosed by esophagogastric endoscopy with biopsy. We performed endoscopic ultrasound-guided Trucut biopsy(EUS-TCB) to diagnose a mediastinal mass in a 49 year-old patient, who visited our hospital because of voice change. During procedure, we accidently found enlarged celiac lymph node, and obtained tissue from the mediastinal lymph node and the celiac lymph node. We confirmed double primary cancer of squamous cell carcinoma in the esophagus and the hypopharynx via esophagogastric endoscopy.

충주 지역에서 10년간 급성심근경색의 임상관찰에 대한 연구

박봉안,류하근,이종혁,김인숙,류주성,유재등,이용구,문언수,김형수 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background: The current treatments of acute myocardial infarct(AMI) Include noninvasive method using thrombolytics and invasive methods such as primary percutaneous transluminal coronary angioplasty(PTCA) and coronary artery bypass graft(CABG)surgery. Although there are many studies comparing the effectiveness of noninvasive and invasive methods, when large clinical centers, 20% of totar hospitals, were excluded, most middle-sized hospitals lacked personnels and facilities for the invasive methods. Thus they opted for the noninvasive methods. Therefore, in this study, the clinical characteristics of AMI patients and the results of thrombolytic & conservative treatment were observed. Method: 137 patients with acute myocardial infarct, who visited KonKuk University Medical Center, ChoongJu Hospital during Sept. 1990 to Sept. 1999 were analysed retrospectively using medical records. Result: The sexual compositions of patients were 63.5% male, and 36.5% female. The mean age for male patients were 56±12.9, and for female patients 68.7±9.6 (p<0.05). The mean age for female patients was significantly older than male patients. The patients in the thrombolytic treatment group had mortality rate of 6.25% which is lower than that of the conservative treatment group at 12% (p>0.05). Conclusion: Although in our study, small number of acute myocardial infarct patients caused the statistical insignificance, rapid revascularization by thrombolytic therapy within 6 hours of onset of symptoms improved mortality rate and early ambulation. And we had good results on AMI with thrombolytic agent in ChungJu including near rural area as primary emergency hospital. Therefore a prospective research with greater number of subjects is needed to develop better treatments for AMI.

[P332] A case of mixed squamous cell carcinoma and sebaceous carcinoma

( Moon Hyung You ),( Joongoon Kim ),( Yeonwoong Kim ),( Byeongsu Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Sebaceous carcinoma is a rare malignant tumor with sebaceous differentiation. It is often seen as a single nodule or mass. Most of them are found in the eyelids, and also in the face and scalp where many sebaceous glands are distributed. Cutaneous squamous cell carcinoma is the second most common primary malignant tumor of the skin and is found mainly in sun-exposed areas including the face in older patients. The cause of sebaceous carcinoma has not been clarified yet, but cases related to drug administration, irradiation or skin diseases such as actinic keratosis, bowen disease and nevus sebaceous have been reported. Only one case has been reported worldwide in which two types of cancer are mixed. A 79 - year - old female patient presented with a polypoid mass on the left forehead for 7 months. There was no symptom and bleeding occurred easily on the surface. On histologic examination of the entire lesion, sebaceous lobules surrounded by basaloid cells, cellular atypia, high mitotic activity was observed on the superficial part of the mass, and nests of pleomorphic squamous cells, which invade subcutaneous fat tissue was observed on the deep part of the mass. We diagnosed the lesion as mixed squamous cell carcinoma and sebaceous carcinoma. We performed wide resection and she showed no evidence of recurrence. We report a case of mixed sebaceous carcinoma and squamous cell carcinoma, which is very rarely reported worldwide.

[P184] A case of atypical fibroxanthoma

( Moon Hyung You ),( Joongoon Kim ),( Yeonwoong Kim ),( Byeongsu Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Atypical fibroxanthoma is an intermediate-grade neoplasm that usually arises on sun-damaged skin in the eighth decade, which is composed of atypical spindle cells. It has a relatively benign clinical course. Clinically, it is typically found in the head and neck of elderly patients, with pink or red colored single papular or nodular lesions smaller than 2 cm in diameter. It is histologically similar with undifferentiated pleomorphic sarcoma, but has a better prognosis. Nine out of 11 cases reported in the Korea so far were present in the head and neck, and all cases were single lesions and showed no distant metastasis. An 84-year-old man presented with a nodular lesion in the left temple. The lesion appeared 3 months ago, and gradually increased in size. It bleeded easily. He underwent biopsy at another hospital and was referred to our hospital because of the suspicion of epithelioid angiosarcoma. Immunohistochemical staining showed strong positivity for CD10, and negativity for CD31, CD34, CD68, SMA, Cytokeratin, and S-100. We diagnosed the lesion as atypical fibroxanthoma and performed wide resection. We report a case of atypical fibroxanthoma which was initially misdiagnosed with epithelioid angiosarcoma.

[P182] A case of Mondor’s disease of the penis

( Moon Hyung You ),( Joongoon Kim ),( Yeonwoong Kim ),( Byeongsu Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Mondor’s disease of the penis is a rare, less well known penile disease that occurs in the superficial veins of the penis. It can occur in sexually active males of any ages. It is presumed that the trauma that occurred during sexual activity is the main cause, and various factors such as infection, pelvic tumor have been reported as the cause. Four cases of Mondor``s disease of the penis were reported in Korea. A 25 - year - old man presented with asymptomatic linear nodule on the penis a month ago. The lesion developed after he squeezed the scrotal furuncle. There were no specific findings on the past medical history, family history, and physical examination. Histological examination of the lesion revealed sclerosis and thickening of the blood vessel wall. Immunohistochemistry revealed CD31 positive and D2-40 negative findings, suggesting vascular lesions rather than lymphatic vessels. We diagnosed the lesion as Mondor``s disease of the penis. This is a rare case of Mondor``s disease of the penis which is rarely reported in Korea. Patient with this disease can easily be misdiagnosed with a sexually transmitted disease, so dermatologists would be able to achieve an accurate differential diagnosis and appropriate treatment by understanding this disease.

A clinical study of 50 patients with pigmented purpuric dermatoses

( Moon Hyung You ),( Joon Goon Kim ),( Yeon Woong Kim ),( Dong Hoon Shin ),( Jong Soo Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Pigmented purpuric dermatosis (PPD) comprises a group of dermatoses that are clinically characterized by petechiae and purpura with a brown, red, or yellow pigmented bases. Several recent reports have suggested that underlying chronic disorders could be etiologic factors of PPD. Objectives: The aim of this study was to examine the clinical findings and etiologic factors of PPD. Methods: A total of 50 patients confirmed as PPD by histologic examination at the Yeungnam University Hospital from 2001 to 2017 were retrospectively analyzed with hospital charts. The co-morbid disorders of the patients were compared with those of the control group. Results: Of the 50 patients, the female to male ratio was 1:1.38. The mean age of patients was 55.0±14.0years. All of the cases involved the lower extremities. The majority (60.0%) had Schamberg’s disease. About two-thirds of patients had medical problems, including hyperlipidemia (40%), hypertension (28.0%), and diabetes mellitus (18%), but there was no statistically significant difference between the control group and patients. A review of the prognoses of 19 patients revealed that 68.4% were clinically improved and that the most common treatment modality was a topical corticosteroid (89.5%). Conclusion: PPD mostly affected the lower extremities of an elderly person and had various clinical manifestations with common histologic features of PPD. The most common underlying disease was hyperlipidemia.

[P164] A case of palisaded neutrophilic and granulomatous dermatitis

( Moon Hyung You ),( Joongoon Kim ),( Yeonwoong Kim ),( Byeongsu Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a histopathologic diagnosis. It can be divided into three stages, and characterized by various clinical features according to each stage. It usually shows erythematous papules on the upper limbs, especially on the fingers and elbows. The association with various systemic inflammatory diseases has been reported, and rheumatoid arthritis is most common. Five cases were reported in Korea and all cases were associated with rheumatoid arthritis. A 46 - year - old man presented with a rash of both fingers and palms that occurred a year ago. There was no underlying disease other than diabetes mellitus. He had arthralgia in the fingers, and physical examination showed tenderness. On histopathologic examination, a large number of palisaded granulomas, neutrophilic debris, and degenerated collagen were observed. All of the autoimmune antibodies were negative in the serologic tests. The patient was diagnosed with PNGD without rheumatoid arthritis because of the absence of arthritis in the finger joints on the radiologic examination. Both lesions and symptoms improved with the use of dapsone and topical corticosteroids. PNGD cases without underlying systemic disease were very rare. Therefore, if a similar lesion is seen, evaluation for systemic condition is essential, and other diseases such as rheumatoid nodule and granuloma annulare should be differntiated through biopsy.

A clinicopathological study of 19 patients with mycosis fungoides

( Moon Hyung You ),( Hye Ri Kim ),( Joon Goon Kim ),( Dong Hoon Shin ),( Jong Soo Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Mycosis fungoides (MF) is the most common type of cutaneous lymphoma, defined as an epidermotropic, primary cutaneous T-cell lymphoma composed of small- to medium-sized T lymphocytes with cerebriform nuclei and with a T-helper phenotype. There are few recent reports about clinicopathological data of MF in Korean literature. Objectives: The aim of this study was to examine the clinicopathological findings of MF. Methods: A total of 19 patients confirmed as MF by histologic examination at the Yeungnam University Hospital from 2001 to 2018 were retrospectively analyzed with hospital charts to determine the clinical manifestations, immunohistochemical findings, treatment, and prognosis. Results: Of the 19 patients, the ratio of males to females was 1.38:1. The mean age of patients was 51.4(±13.7) years. The majority (89.5%) involved sun-protected areas, and 7 cases (36.8%) involved sun-exposed areas. Most cases were stage IA (47.4%), followed by stage IB (21.1%). Immunohistochemistry revealed positivity for CD4(100%), and CD8(50.0%). A review of the prognoses of 14 patients revealed that 71.4% were clinically improved. Narrow-band UVB phototherapy was chosen as primary treatment in 14 cases (73.7%), followed by topical corticosteroid in 12 cases (63.2%). Conclusion: MF mostly affected the sun-protected areas of an elderly male and had various clinicopathological manifestations. Most cases were stage IA, and had favorable prognoses.