Sustained-release praziquantel tablet : pharmacokinetics and the treatment of clonorchiasis in beagle dogs

Hong, Sung-Tae,Lee, Sang Hyup,Lee, Seung-Jin,Kho, Weon-Gyu,Lee, Mejeong,Li, Shunyu,Chung, Byung-Suk,Seo, Min,Choi, Min-Ho 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12

Praziquantel is rapidly absorbed and secreted; and thus fractional doses are recommended for the treatment of cestode and trematode infections. In the present study, we developed a new praziquantel tablet formula allowing sustained-release (SRP). In vitro dissolution of SRP tablets showed that praziquantel at 300 ㎎/tablet combined with hydroxypropyl methylcellulose dissolved completely at a constant rate over 10 h, whereas the conventional praziquantel tablet (PZQ) was only 40% dissolved. Pharmacokinetic studies in dogs confirmed that SRP was absorbed more slowly than PZQ. The mean value of the area under the concentration/time curve from 0 h to the final observation time, the maximum concentration in serum, and the time of maximum concentration in serum for SRP were 3.471.500 ng/min for 0.25 ㎖, 10,300 ng for 0.25 ㎖, and 192 min. while the values for PZQ were 688,600 ng/min for 0.25㎖, 2,500 ng for 0.25㎖, and 135 min. The cure rate in dogs with a heavy infection (500 metacercariae) treated with a single dose of SRP (150 ㎎/tablet) at 50 ㎎/㎏ was 80%, while in dogs treated with a single dose of SRP (300 ㎎/tablet) at 30 mg/kg it was 60%, and the cure rate with PZQ was 20%. In each case. the egg reduction rate was similar (over 90%). No abnormal liver functions or hepatic or renal pathologies were observed in dogs administered with SRP at 30 ㎎/㎏. The SRP tablet showed sustained release and slow absorption; and it had an improved anthelmintic efficacy against Clonorchis sinensis in experimental dogs. compared with conventional praziquantel.

요관압 상승시 신혈류량 조절에 prostaglandin이 미치는 효과

민영기,양훈모,김종규,이석호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Higher ureteral pressure than in normal condition causes increase in renal blood flow (RBF) and partial impairment of the autoregulation of RBF. Higher ureteral pressure increased renal prostaglandin production, it is not clear whether or not it is also responsible for partial impairment of the autoregulation of RBF. Therefore, we investigated the role which prostaglandin play in the autoregulation of RBF, studying the interaction between ureteral pressure and RBF autoregulation may reveal the role of prostaglandin in tubuloglomerular feedback. For the purpose of this experiment, six anesthetized mongrel dogs were prepared for the measurements of RBF, mean systemic and renal arterial pressure (RAP) and the manipulation of ureteral pressure to 0 cmH20, 20 cmH20 and 40 cmH20. The autoregulation curves were determined during both control and elevation of the ureteral pressure, before and after the pretreatment with indomethacin, a cyclooxygenase inhibitor. The desired ureteral pressure was achieved by vertically elevating the water-filled reservoir connected to the ureteral catheter to 20 cm and 40 cm above the kidney level. In response to the elevation of the ureteral pressure, RBF increased from 167±11 ml/min to 185±8 ml/min, 204±11 ml/min respectively and the renal arterial pressure and the systemic arterial pressure didn't change significantly. During 0 mmHg of ureteral presure threshold pressure of RBF autoregulation was 59±3 mmHg. On the other hand, during 20 cmH20, 40 cmH20 of ureteral pressure, the autoregulation curves shifted upward and rightward from control, threshold pressure is elevated by 74±3 mmHg. The pretreatment of the dogs with indomethacin failed to affect the lower limit of RBF autoregulation during both control (63±5 mmHg) and the elevated ureteral pressure (77±5 mmHg). Since RBF failed to increase in response to the elevated ureteral pressure, RBF autoregulation curves obtained during the elevated ureteral pressure shifted only rightward from indomethacin control. The results indicate that the increased intrarenal level of prostaglandin by increased ureteral pressure or prostaglandin-induced vasodilation does not appear to bear any relation to the reduction in the autoregulatore capacity during elevated ureteral pressure. It seems that the partial impairment of the autoregulation during acute ureteral obstruction is due to the consumption of tubuloglomerular feedback mechanism at 0 mmHg of ureteral pressure and that prostaglandin is neither mediator nor effector of tubuloglomerular feedback mechanism.

농촌병원과 도시 종합병원 외래환자의 수진행동에 관한 비교연구

민현옥,이종숙 中央醫學社 1993 中央醫學 Vol.58 No.11

In order to know the sick role behavior of outpatients who visiting the Hospitals in City and Rural, this questionnaire survey was conducted from Dec, 1990 to Feb, 1991 in the five selected hospitals; 3 general hospitals in Taejeon City al d 2 general hospitals in Chungnam provincial for 876 outpatients. The major findings of this survey were as follows: 1. A total of 49.3 % of the study population were male and female were 50.7 % and average age were 40.14 years old. 2. The average time spent on diagnosis and treatment in hospitals was 138.6 minutes, the spent times were longer in hospitals in city than one in Rural area. 3. The average time spent on diagnosis and treatments by departments was 168.7 min. in internal medicine, 136.1 min. in orthopedic surgery, 104.4 min. in obstetrics and gynecology, 86.8 min. in general surgery, 81.4 min. in pediatrics. 4. The previous medical facility from which patients were transport were 37.2 % in clinic, 16.4 % in hospital, 4.2 % in health center and subcenter and 38.8 % in no transfarted medical facility. 5. The Routes of hospital choice were 30.9 % in patients' own first choice, 35.8 in transferred from other facility on patients' own decision, 26.5 % in recommended by other medical facility. 6. The reasons of hospital choice were 32.1 % in previous experience and familiarity, 26.6 % in bad treatments in previous hospitals, 28.0 % in good facility and equipment. 7. The dissatisfaction against currently treating hospital were 58.9 % in long waiting time, 16.4 % in insufficient explanation of disease, 16.5 % in unkindness, 13.4 % in diagnosis time is too short, 26.6 % in no dissatisfaction. 8. The attitude on medical care delivery system were 34.8 % in acceptable, 23.4 % in not acceptable, 36.5 % in don't know.

P211 : Red blood cell distribution width is increased in patients with psoriasis vulgaris: a retrospective study on 261 patients

( Dae Suk Kim ),( Dongyun Shin ),( Minseok Lee ),( Hyunjoong Jee ),( Tae Gyun Kim ),( Sung Hee Kim ),( Do Young Kim ),( Soo Min Kim ),( Min Geol Lee1 ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Objectives: Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its association with disease severity. Methods: We conducted a retrospective study of psoriasis patients seen in single hospital in Korea. Demographic data, hematologic parameters and disease severity were collected. Results: A total of 261 psoriasis patients and 102 healthy controls were included in our study. The RDW value was significantly increased in psoriasis patients compared to healthy control (p=0.037). Compared to mild psoriasispatients (PASI<7), moderate to severe patients (PASI≥7) showed significantly higher RDW values (p=0.044). RDW did not show significant correlation with PASI (p=0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (p=0.219). Conclusion: Patients with psoriasis showed increased RDW values compared to healthy controls. It was also higher in moderate and severe disease group than mild group. RDW values were increased in psoriasis patients and it is possible that RDW value reflects the inflammatory status of psoriasis, but this needs to be evaluated in near future.

Effects of Supercritical Carbon Dioxide Treatment on Meat Quality and Sensory Evaluation in Soy Sauce and Hot-pepper Paste Marinated Pork

Young Min Choi,Sang Hoon Lee,Jee Hwan Choe,Kyoung Heon Kim,Min Suk Rhee,Byoung Chul Kim 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.5

The objective of this study was to investigate the effects of supercritical carbon dioxide (SC-CO2) treatment on meat quality and sensory evaluation of marinated pork. Meat marinated in two traditional Korean marinades, soy sauce and hot-pepper paste, and raw marinated meat were then treated with 7.4, 12.2, or 15.2 MPa CO2 at 31.1oC for 10 min. The SC-CO2 treatments had no effect on the meat pH (p>0.05) or Warner-Bratzler shear force (p>0.05). There was no significant difference (p>0.05) in the total loss (sum of treatment loss and cooking loss) between the control and SC-CO2 treated samples at 15.2 MPa (soy sauce marinated pork: 21.78 vs. 18.97%; hot-pepper marinated pork: 21.61 vs. 18.01%). After the SC-CO2 treatment, lighter surface colors were observed in the treatment samples compared to those of the control samples (p< 0.001). However, tasting panelists were unable to distinguish a difference in color or in overall acceptability of the control and treatment (p>0.05). In the case of soy sauce marinated pork, when SC-CO2 applied at 15.2 MPa and 31.1oC for 10 min, treatment samples showed a tenderer meat than the control samples. Therefore, the SC-CO2 treatment conditions had no adverse effects on the sensory quality characteristics of the marinated meat products.

Antibacterial Effect and Deodorization Effect of Extracts from Different Parts of Zingiber officinale

Young Suk Lee,Young Ju Kang,Min Jeong Ryu 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.4

목적: 생강 부위별 추출물의 피부 상재균에 대한 항균효과 및 암모니아에 대하 소취능을 평가하여 항균소재 및 기능성 향장품 소재 로서의 가능성을 예측하고자 한다. 방법: 피부 상재균에 대한 항균효과는 paper disc 방법으로 측정하였다. 소취효과 측정은 암모 니아 가스 제거 실험을 하였다. 결과: 생강 부위별(잎, 줄기, 뿌리) 추출물 항균효과 측정 결과 S. aureus에 대한 항균효과는 5 mg/ mL 농도에서 각각 3 mm, 3 mm, 2 mm의 clear zone이 확인되었다. S. epidermidis에 대한 항균효과는 각각 8 mm, 5 mm, 4 mm 의 clear zone이 확인되었다. 여드름의 원인균인 P. acnes에서는 각각 4 mm, 3 mm, 1 mm의 clear zone이 확인되었다. P. ovale에 서는 각각 6 mm, 5 mm, 4 mm의 clear zone이 확인되었다. M. furfur에서는 각각 4 mm, 3 mm, 2 mm의 clear zone이 확인되었다. C. albicans에서는 각각 4 mm, 3 mm, 2 mm의 clear zone이 확인되었다. 마지막으로 T. mentagrophytes에 대한 항균효과를 측정 한 결과 5 mg/mL 농도에서 생강 잎 추출물은 6 mm, 줄기 추출물은 4 mm, 뿌리 추출물은 3 mm의 clear zone이 확인되었다. 암모 니아에 대한 소취효과를 측정한 결과 120 min에는 생강 잎 추출물은 98%, 줄기 추출물은 95%, 뿌리 추출물은 91%의 소취효과가 확인되었다. 결론: 생강 부위별 추출물 중 잎 추출물이 7종의 피부상재균에 대한 항균효과도 가장 우수하였으며, 소취효과도 생강 잎 추출물이 가장 높은 효과가 확인되어 항균소재 및 기능성 향장품 소재로서의 가능성을 확인하였다. Purpose: Using extracts from different parts of Zingiber officinale , we aimed to evaluate its antibacterial effect on skin flora and its deodorization effect on ammonia to determine its potential as an antimicrobial ingredient and functional herbal cosmetic ingredient. Methods: The antibacterial effect on skin flora was examined using the paper disc method and the deodorization effect on ammonia was examined by the gas detection method. Results: After evaluating the antibacterial effects of extracts from different parts (leaves, stems, and roots) of Zingiber officinale , antibacterial activity was observed against Staphylococcus aureus (S. aureus ) at a concentration of 5 mg/mL. The leaf, stem, and root extracts had 3 mm, 3 mm, and 2mm clear zones, respectively. For the antibacterial effect against Staphylococcus epidermidis (S. epidermidis ), there were 8 mm, 5 mm, and 4mm clear zones for the leaf, stem, and root extracts, respectively. For Propionibacterium acnes (P. acnes ), a bacterium that causes acne, there were 4 mm, 3 mm, and 1mm clear zones for the leaf, stem, and root extracts, respectively. The results for Pityrosporum ovale (P. ovale ) showed 6 mm, 5 mm, and 4 mm clear zones for the leaf, stem, and root extracts, respectively. For Malassezia furfur (M. furfu ), there were 4 mm, 3 mm, and 2 mm clear zones for the leaf, stem, and root extract, respectively. For Candida albicans (C. albicans ), there were 4 mm, 3 mm, and 2mm clear zones for the leaf, stem, and root extracts, respectively. Finally, after evaluating the antibacterial effect against Trichophyton mentagrophytes (T. mentagrophytes ) at a concentration of 5 mg/mL, we found 6 mm, 4 mm, and 3 mm clear zones for the leaf, stem, and root extracts, respectively. After evaluating the deodorization effects of Zingiber officinale extracts on ammonia, at 120 min, the deodorization effect was 98%, 95%, and 91% for the leaf, stem, and root extracts, respectively. Conclusion: Among the three extracts of Zingiber officinale , the leaf extract had the highest antibacterial effect against the seven types of skin flora as well as the highest deodorization effect, thus confirming its potential as an antibacterial ingredient and functional herbal cosmetic ingredient.

붕장어 부산물로 제조한 붕장어탕의 식품학적 특성

허민수(Min Soo Heu),이택상(Take Sang Lee),김혜숙(Hye-Suk Kim),지성준(Seung Joon Jee),이재형(Jae Hyoung Lee),김형준(Hyung Jun Kim),윤민석(Min Seok Yoon),박신호(Shin Ho Park),김진수(Jin-Soo Kim) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.4

붕장어 가공부산물인 머리와 frame를 효율적으로 이용하기 위한 일련의 연구로 붕장어 부산물을 이용한 붕장어탕의 개발을 시도하였고, 아울러 이의 식품성분 특성에 대하여도 살펴보았다. 살균조건 및 가온일수에 따른 붕장어탕의 저장성 부여를 위한 최적 살균조건은 F? value=8분으로 판단되었다. 붕장어탕의 일반성분은 수분의 경우 90.7%, 조단백질의 경우 4.8%, 조지방의 경우 2.6%, 조회분의 경우 1.5%를 나타내었다. 붕장어탕의 엑스분 질소 함량은 243.1 ㎎/100 g으로 시판 추어탕의 208.0 ㎎/100 g보다 높았다. 붕장어탕의 총 아미노산 함량은 4,310 ㎎/100 g이었고, 주요 구성아미노산은 glutamic acid(637.3 ㎎/100 g, 14.8%), glycine(409.1 ㎎/100 g, 9.5%) 및 alanine(404.4 ㎎/100 g, 9.3%)등이었다. 붕장어탕은 관능적인 비린내는 거의 감지되지 않았고, 맛은 우수하였으며, 항산화능이 인정되었으나 ACE 저해능은 크게 기대할 수 없었다. For the effective use of the conger eel by-products, such as head and frame, Tang, which is the Korean-type soup, from conger eel by-products (TCEB) was developed and its food component characterization was compared with that of commercial Chueotang, loach Tang. According to the results of viable cells and coliform group of TCEB heated at 115oC for various times, the reasonable F0 value was 8 min. The proximate composition of TCEB was 90.7% for the moisture, 4.8% for the protein, 2.6% for the lipid, and 1.5% for the ash. The extractive-nitrogen content of TCEB was 243.1 ㎎/100 g, which was higher than that of commercial Chueotang, 208.0 ㎎/100 g. The total amino acid content of TCEB was 4,310 ㎎/100 g and its major amino acids were glutamic acid (637.3 ㎎/100 g, 14.8%), glycine (409.1 ㎎/100 g, 9.5%) and alanine (404.4 ㎎/100 g, 9.3%). TCEB was not felt in the sensual fish odor and its sensual taste was good. The health functional properties for health of TCEB were 1.29 as a PF (protection factor) for antioxidative activity and 39.4% for angiotensin Ⅰ converting enzyme (ACE) inhibiting activity.

흡연이 Gastric Emptying Time에 미치는 영향

조민구(Min Koo Cho),정순영(Sun Young chung),김소연(So Yon Kim),문희승(Mun Hee Seung),김진석(Jin Suk Kim),이석호(Suk Ho Lee),이권전(Gwon Jun Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2

The effect of cigarette smoking on gastric emptying was examined in 25 healthy volunteers by means of Tc-sulfur colloid labeled-solid meal. The volunteers underwent GET measurement two times: before smoking and after smoking two cigarettes. Before smoking, the each average of GET T25% T50%, T75%, was 18 +- 5.2, 40 +- 6.7, 90 +- 18.4 min and after cigarette smoking the each average of GET T25%, T50%, 75% was 30 +- 8.3, 64 +- 12.6, 114 +- 7.0 min. We concluded that cigarette smoking significantly delayed gastric emptying of a solid meal (p< 0.05).

함산소불화 활성탄소섬유를 이용한 저농도 크롬이온의 흡착 특성

김민지 ( Min Ji Kim ),정민정 ( Min Jung Jung ),최석순 ( Suk Soon Choi ),이영석 ( Young Seak Lee ) 한국공업화학회 2015 공업화학 Vol.26 No.4

In this work, activated carbon fibers (ACFs) were oxyfluorinated and their adsorption ability for the low concentration of hexavalent chromium in an aqueous solution was investigated. The pore structure and surface properties of ACFs were examined by BET and X-ray Photoelectron Spectroscopy (XPS), respectively. Due to the oxyfluorination treatment, the content of (C-O) bond on ACFs surface which influences the adsorption capacity for heavy metal ions increased largely, resulting that Cr6+ adsorption equilibrium reached quickly within 10 min. In addition, the maximum removal efficiency at the initial Cr6+ concentration of 20 ppm was observed, which is a 100% improvement compared to that of non-treated ACFs. These results suggest that the oxyfluorination of ACFs can be applied as a good surface treatment for the effective adsorption of the low concentration of Cr6+.

Feasibility of Calibrating Smartphone to Access Physical Activity

이정민(Jung Min Lee),김영원(Young Won Kim),권이석(Yi Suk Kwon),Timothy R. Derrick,Gregory J. Welk 한국체육측정평가학회 2015 한국체육측정평가학회지 Vol.17 No.3

대부분의 신체활동측정을 위해 연구들은 가속도계를 이용하여 측정되어져 왔다. 하지만, 스마트폰이 대중화 되면서스마트폰에 내장된 가속도계를 이용하여 신체활동을 측정 할 수 있는 에플리케이션들이 빈도 높게 늘어나고 있다. 따라서 이 연구에서는 스마트폰에 내장되어 있는 가속도계를 이용하여 에너지 소비량을 구하는 공식을 만들고 그 공식을 현재 연구중심으로 많이 사용되는 가속계와 비교하고 교차분석을 통하여 정확성과 실용성을 검증하는 것이다. 이러한 목적을 달성하기 위하여 건강한 성인 44명을 편의추출 하여 가속계와 스마트폰을 착용시켜 69분 동안 다양한 일상생활 활동을 시켰으며 신체활동 측정의 준거검사인 간접열량계(Oxycon Mobile)가 사용되었다. 회귀분석을 통하여 만들어진 연산은 교차 타탕도 분석을 통하여 정확도를 검증하였고 검사도구의 정확성은 절대오차율(%)을 계산하고 검사도구간 상관계수 (r), Bland-Altman plot 과 equivalence testing 사용하여 검증하였다. 연구결과에 의하면 스마트폰을 통해 얻어진 절대오차율은 (42.4%)를 보였고 Freedson`s 기준치와 비교했을 때는 (38.2%)를 보였다. 그러나 스마트폰을 통해 만들어진 연산은 걷기 와 달리기의 에너지 소비량은 측정하는데 유의하다는 결과가 나왔다. 추후, 스마트폰만을 이용한 신체활동 측정이 다양하게 필요하고 그 정확성을 검증하는 연구들도 필수적으로 요구된다. The purpose of the study was to develop algorithms to predict energy expenditure (EE) and to evaluate their utility compared to existing accelerometer technology. Forty-four participants wore an Actigraph GT3X (AG3X) and the Samsung Galaxy S2 Smartphone (SP) over a 69 min period. Oxygen consumption (VO<sub>2</sub>) was simultaneously measured by a portable indirect calorimetry system. EE prediction equations for the SP were developed from the walking and running activities using standard regression methods. The equation was then cross-validated on a separate holdout sample (n=22) using equivalence testing to evaluate accuracy. The overall mean absolute percentage errors were large for both the SP algorithm (42.4%) and the Freedson`s AG3X algorithm (38.2%). However, the estimated METs from the SP was statistically equivalent to the measured METs for the two activities used in calibration: walking (90% CI: 2.85, 3.50 kcal·min-1) and running (90% CI: 7.64, 8.25 kcal·min-1). Other activities were not accurately assessed with the SP but none of the estimates from the AG3X met the statistical criteria for equivalency. The study demonstrates that data from SP can be easily calibrated to estimate EE and that accuracy is comparable to the common research-grade monitors.