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      저자 : ( Masatake Kuroha ) (검색결과 1 건)
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        Long-term prognosis of Japanese patients with biologic-naive Crohn’s disease treated with anti-tumor necrosis factor-α antibodies

        ( Rintaro Moroi ),( Katsuya Endo ),( Katsutoshi Yamamoto ),( Takeo Naito ),( Motoyuki Onodera ),( Masatake Kuroha ),( Yoshitake Kanazawa ),( Tomoya Kimura ),( Yoichi Kakuta ),( Atsushi Masamune ),( Yo 대한장연구학회 2019 Intestinal Research Vol.17 No.1

        Background/Aims: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn’s disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments. Methods: This was a retrospective, observational, single-center cohort study. Japanese CD patients treated with either infliximab or adalimumab as a first-line therapy were analyzed. The cumulative retention rates of the biologics, relapse-free survival, and surgery-free survival were analyzed using Kaplan-Meier methods. The clinical factors associated with the long-term outcomes were estimated by both the log-rank test and Cox proportional hazard model. Results: The cumulative retention rate was significantly higher in the group with a concomitant elemental diet of ≥900 kcal/day, baseline C-reactive protein (CRP) levels <2.6 mg/dL, and baseline serum albumin levels ≥3.5 g/dL, respectively. The baseline serum albumin levels were also associated with both relapse-free and surgery-free survival. The lack of concomitant use of an elemental diet ≥900 kcal/day was identified as the only independent risk factor for the withdrawal of the biologics. Conclusions: Baseline CRP levels and serum albumin levels could affect the long-term outcomes in CD patients. Concomitant elemental diet of ≥900 kcal/day could have a positive influence on clinical treatment course. (Intest Res 2019;17:94-106)

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