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( Mao Qiang Man ),( Carolyn Cheung ),( Melanie Hupe ),( Debra Crumrine ),( Peter M Elias ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Epidermal permeability barrier function plays a crucial role in regulating cutaneous function. Improvement of epidermal barrier function has become a valuable approach to prevent and treat certain skin disorders. However, the commercially available barrier enhancing products are expensive and not readily available in developing countries, such as African and some countries in Asia. In the present study, we first optimized an inexpensive formulation that can enhance epidermal permeability barrier and then the basis thereof. Hairless mice were treated topically with various formulation twice-daily for 3 days. At the end of treatments, permeability barrier function was assessed with a Tewameter. The efficacy of optimized formulation on barrier function in tape-stripped skin was also assessed. Our results show that topical optimized formulation significantly enhanced basal permeability barrier function and permeability barrier homeostasis after tape stripping while basal stratum corneum hydration and skin surface pH remained unchanged. Improved barrier function correlated with enhanced epidermal involucrin and loricrin expression, and lamellar body production. Moreover, epidermal antimicrobial pepetide, CAMP expression, remarkably increased after topical applications of optimized formulation. These results demonstrate that this optimized inexpensive formulation can effectively improves epidermal permeability barrier function by stimulating epidermal differentiation, lamellar body production, as well as cutaneous antimicrobial peptide production. This optimized formulation could be widely used as inexpensive regimen in prevention and treatment of skin disorders characterized by permeability barrier dysfunction in addition to as a conventional skin care product, especially for developing countries.
Alteration of Stratum Corneum pH in Aged Skin and Its Clinical Significance
( Mao-qiang Man ),( Peter M. Elias ) 한국피부장벽학회 2017 한국피부장벽학회지 Vol.19 No.2
In comparison with young skin, aged epidermis displays multiple functional abnormalities, including elevated stratum corneum pH and compromised permeability barrier homeostasis. In this article, we briefly review the alteration of stratum corneum pH, its underlying mechanisms, as well as the clinical significance of elevated stratum corneum pH in the aged population. We also brief the rapidly expanding and clinical implications of SC acidification.
( Shunpeng Song ),( Peter M Elias ),( Theodora M Mauro ),( Mao Qiang Man ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Aged skin is featured by compromised epidermal permeability barrier homeostasis. Improvement of epidermal permeability barrier in aged skin is quite a challenge. Previous study demonstrated that topical hesperidin improves epidermal permeability barrier homeostasis in young mice. However, whether topical applications of hesperidin benefit epidermal permeability barrier function is not known yet. In the present study, we assessed the influence of topical applications of hesperidin on epidermal permeability barrier function and its underlying mechanisms in aged murine model. 12-15 month old hairless mice were topically treated with either 2% hesperidin or 70% ethanol alone twice daily for 25 days. At the end of study, stratum corneum function was assessed with an MPA5 physiology monitor. And barrier recovery rates were determined at 2 and 4 hours after barrier disruption by repeated tape-stripping. Our results show that topical applications of hesperidin lowered basal skin surface pH and increased basal transepidermal water loss. However, barrier recovery was significantly accelerated by hesperidin. The improved barrier function correlated with up-regulation of barrier-related protein, lipid synthetic enzyme and their mRNA expression. Moreover, topical hesperidin also significantly increased expression of epidermal mRNAs for mBD3, NHE1 and sPLA2g2f. These results suggest that topical application of hesperidin could be useful for preventing skin aging and treating aged skin.
Kim, Minjeong,Jung, Minyoung,Hong, Seung-Phil,Jeon, Hyerin,Kim, Min-Jung,Cho, Mee-Yon,Lee, Seung-Hun,Man, Mao-Qiang,Elias, Peter M.,Choi, Eung-Ho Blackwell Publishing Ltd 2010 Experimental dermatology Vol.19 No.6
<P><I>Please cite this paper as:</I> Topical calcineurin inhibitors compromise stratum corneum integrity, epidermal permeability and antimicrobial barrier function. Experimental Dermatology 2010; 19: 501–510.</P><P>Abstract</P><P>Background: </P><P>Topical calcineurin inhibitors (TCIs) such as pimecrolimus and tacrolimus have recently been used for dermatologic diseases including atopic dermatitis instead of topical glucocorticoids, because they display comparable efficacy, but less-frequent side effects. Although even short-term topical glucocorticoid compromise epidermal permeability barrier homeostasis, the effects of TCI on barrier function have not yet been reported. However, viral infections such as eczema herpeticum and molluscum contagiosum, which could indicate an impaired skin barrier, continue to occur with TCI use in atopic dermatitis.</P><P>Objectives: </P><P>We determined here whether TCIs disrupt epidermal permeability barrier and antimicrobial function, and whether these effects can be prevented.</P><P>Methods and results: </P><P>In normal humans, topical pimecrolimus and tacrolimus applied twice-daily for 5 days, delay barrier recovery without an increase in basal transepidermal water loss was observed. Co-application of physiologic lipid mixture (PLM) containing an equimolar ratio of ceramides, cholesterol and free fatty acids normalized barrier homeostasis in the face of topical TCIs. In hairless mice, 4 days of TCI treatment also disrupted barrier function significantly. TCIs-treated epidermis showed the decrease of epidermal lipid content, lamellar body number and secretion, and lipid synthesis-related enzymes such as 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, serine-palmitoyl transferase and fatty acid synthase, implying decreased lipid synthesis. TCIs also suppressed expression of IL-1&agr; and antimicrobial peptides, CRAMP and mouse &bgr;-defensin 3. However, these TCI-induced abnormalities can be overridden by topical replacement with PLM.</P><P>Conclusions: </P><P>Our results demonstrate that TCIs induce negative effects on the skin barrier including permeability and antimicrobial functions, which are mediated by decreasing epidermal lipid synthesis, lamellar body secretion and antimicrobial peptides expression through suppression of cytokine such as IL-1&agr;, therefore co-treatment with PLM would be helpful to overcome these negative effects.</P>