http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
에틸 아크릴레이트 아이오노머의 성질에 미치는 양이온 크기의 영향
조규성,나연화,김희석,김준섭,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1
The effects of the size of cations on the properties of polyfethyl acrylate-co-metal acrylate) ionomers containing 3.8 mol% of ionic moiety were investigated. It was found that with changing cations, matrix T_(g)s seem to remain constant; however, cluster T_(g)s increase with decreasing the size of cations. Since ion-hopping occurs at a cluster T_(g) and the electrostatic force of ion pairs decreases with the size of ions increasing, it was suggested that the effect of the size of cation on a cluster T_(g) is operative, but not on a matrix T_(g). It was also found that activation energies for a cluster T_(g) were decreased with decreasing the size of cations; which means that the activation energy values for a cluster T_(g) are not directly related to the cluster T_(g)s. In the present study, the highest value of a cluster T_(g) for the Li ionomer may be one of the reasons why the Li ionomer has the lowest value for an activation energy.
산국 (Chrysanthemum boreale) 휘발성 추출액의 항균 및 항진균활성
차정단,김태영,우원홍,정규용,김강주,길봉섭 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1
To investigate the antimicrobial and antifungal activity of Chrysanthemum boreale(C. boreale) essential oil, the growth inhibition against Aspergillus nidulans, Fusarium oxysporum, Alternaria mali, Staphylococcus aureus, Streotococcus pyogenes, Streptococcus mutans and Escherichia coli in the presence of the essental oil was monitored by agar dilution method. The antifungal effect of C. boreale on Aspergillus nidulans, Fusarium oxysporum and Alternaria mali as affected at the concentration of 400 ppm. The antibacterial effect of C. boreale on staphylococcus aureus, streptococcus pyogenes and Streptococcus mutans was affected at the concentration of 0.4 μl, while growth of E. coli was not inhibited at the concentration of essential oil. The results of this experiment on microorganisms indicated that naturally occuring chemical substances from C. boreale might have biologically toxic activities, that is, allelopathic potentials to the microorganisms.
강릉수력발전소 발전수 방류 전후의 남대천 수질과 미생물 분포
심혜숙,김규중,김형섭,최창근,전방욱 江陵大學校東海岸地域硏究所 1993 東海岸硏究 Vol.4 No.1
강릉수력발전소의 발전수 방류가 강릉 남대천의 수질 및 미생물 분포에 미치는 영향을 조사하였다. 정점 3 상류지역의 발전수 방류는 수질에 상당한 영향을 끼쳐 정점 3 및 정점 4의 수질은 악화되고 정점 5, 정점 6 및 정점 7의 수질은 개선되었다. 미생물 분포도 이와 유사하여 정점 3 및 정점 4의 세포수는 상당히 증가한 반면 정점 5, 정점 6 및 정점 7에서는 대체적으로 감소하였다. 이 결과로 미루어보아 강릉수력발전소의 발전수는 희석효과에 의해 수질 및 미생물 분포를 변화시키는 것으로 사료된다. The effects of water discharged from Kangnung hydropower plant on the water quality and some bacterial population of Namdaecheon Stream, Kangnung were investigated. The water discharged above station 3 affected the water quality significantly; the water quality of station 3 and station 4 took a turn for the worse, however those of station 5, station 6 and station 7 changed for the better. It was also true with the bacterial population; The number of cells of bacteria increased in station 3 and 4, but the number significantly decreased in station 5, station 6, and station 7. The data suggested the idea that the water discharged from Kangnung hydropower plant changed the water quality and some bacterial population by dilution effect.
포타슘 술포네이트 폴리스타이렌 아이오노머의 기계적인 성질에 미치는 Crown ether의 영향
나연화,조규성,이법원,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1
The effects of crown ether on the dynamic mechanical properties of potassium sulfonated polystyrene ionomer were investigated. As expected, it was found that when crown ether molecules were added to the ionomer, the crown ether molecules interacted with K^(+) cations and weakened the ionic interaction between K^(+)/sulfonate ion pairs of the ionomer significantly. Thus, no multiplets were present, and, in turn, no clustering was found. When the ether was added to interact with 50% of K^(+) cations, weak clustering was observed: the clustering was slightly stronger than that of a 50% neutralized ionomer. From this result, it was speculated that in the 50% neutralized sample H^(+) ⇔ K^(+) cation exchange occurs rapidly between -SO₃H and -S0₃K groups in multiplets. which weakens ionic interactions. In the 50% crown ether-added sample, however, -S0₃- group, instead of -S0₃H, is present, and thus no cation exchange is expected to occur.
Kim, Tae Ha,Kim, Mi Ae,Kim, Kyeong Seop,Kim, Jae Won,Lim, Han Kyu,Lee, Jung Sick,Sohn, Young Chang Elsevier 2017 Comparative biochemistry and physiology. Part A, M Vol.209 No.-
<P><B>Abstract</B></P> <P>Gonadotropin-releasing hormone (GnRH) is a key neuropeptide regulating reproduction in humans and other vertebrates. Recently, GnRH-like cDNAs and peptides were reported in marine mollusks, implying that GnRH-mediated reproduction is an ancient neuroendocrine system that arose prior to the divergence of protostomes and deuterostomes. Here, we evaluated the reproductive control system mediated by GnRH in the Pacific abalone <I>Haliotis discus hannai</I>. We cloned a prepro-GnRH cDNA (<I>Hdh-GnRH</I>) from the pleural-pedal ganglion (PPG) in <I>H. discus hannai</I>, and analyzed its spatiotemporal gene expression pattern. The open reading frame of <I>Hdh-GnRH</I> encodes a protein of 101 amino acids, consisting of a signal peptide, a GnRH dodecapeptide, a cleavage site, and a GnRH-associated peptide. This structure and sequence are highly similar to GnRH-like peptides reported for mollusks and other invertebrates. Quantitative polymerase chain reaction demonstrated that <I>Hdh-GnRH</I> mRNA was more strongly expressed in the ganglions (PPG and cerebral ganglion [CG]) than in other tissues (gonads, gills, intestine, hemocytes, muscle, and mantle) in both sexes. In females, the expression levels of <I>Hdh-GnRH</I> mRNA in the PPG and branchial ganglion (BG) were significantly higher at the ripe and partial spent stages than at the early and late active stages. In males, <I>Hdh-GnRH</I> mRNA levels in the BG showed a significant increase in the partial spent stage. Unexpectedly, <I>Hdh-GnRH</I> levels in the CG were not significantly different among the examined stages in both sexes. These results suggest that <I>Hdh-GnRH</I> mRNA expression profiles in the BG and possibly the PPG are tightly correlated with abalone reproductive activities.</P>
Kim, Kyu-pyo,Park, Seong Joon,Kim, Jeong-Eun,Hong, Yong Sang,Lee, Jae-Lyun,Bae, Kyun-Seop,Cha, Hyunju,Kwon, Sool-Ki,Ro, Seonggu,Cho, JoongMyung,Kim, Tae Won Springer-Verlag 2015 Investigational new drugs Vol.33 No.5
<P>Purpose The aim of the present study was to assess the safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and efficacy of single and multiple doses of intravenous CG200745, a novel histone deacetylase (HDAC) inhibitor, in patients with advanced solid malignancies. Experimental Design Two to six patients received intravenous CG200745 according to the 2?+?4 dose-escalating method. This first-in-human trial was comprised of two parts: Part 1 was a single ascending dose, and Part 2 was multiple ascending doses weekly for 3?weeks, and then 1?week off. For the first cycle, pharmacokinetic sampling for CG200745 and pharmacodynamic sampling for acetylated histone H4 in peripheral blood mononuclear cells (PBMCs) were performed on day 1 for Part 1 and on days 1 and 15 for Part 2. Examination of acetylated histone H4 in pre- and post-biopsy samples was performed in accessible patients. Results In all, 28 patients were treated at 13 dose levels (1.8-250?mg/m(2)) and received a total of 71 cycles of CG200745. Hematologic toxicities included grade 3/4 neutropenia (22.2?%) that did not last a week and non-hematologic toxicities included fatigue (22.2?%) and anorexia (16.7?%) that did not exceed grade 2. No dose-limiting toxic effects were noted. Dose proportionality was observed for both the maximum concentration and area under the curve. The elimination half-life was 5.67??2.69?h (mean??standard deviation). An increase in PBMC acetylated histone H4 was observed at dose levels up to 51?mg/m(2), which plateaued at higher dose levels. At 24?h, 75?% of patients (6/8) showed higher relative acetylation in tumor tissue compared to PBMCs. Although there was no partial or complete response, 57.1?% of patients (16/28) had stable disease that lasted at least 6?weeks. Conclusions CG200745 can be safely administered at effective dose levels that inhibit HDAC in PBMCs and tumor tissue. Although MTD was not reached, further escalation was not performed because acetylated histone H4 plateaued at dose levels higher than 51?mg/m(2). Additional phase II trials are recommended at 250?mg/m(2).</P>