정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

老人의 園藝活動參與에 따른 餘暇 및 生活滿足度의 關係

정재은,이광우,심우경 한국식물인간환경학회 2001 인간식물환경학회지 Vol.4 No.1

This study was designed to probe the relation between participation in horticultural for all activities and leisure and life satisfaction of the older adults. A total of 388 older adults over the age of 60 were included as subjects of the study, The subjects of this study were divided by two groups: 250 participants in horticultural activities and 138 non-participants. The data collected from the questionnaires designed for this study were consisted of responses to items constructed to represent each variable. For data analysis, t-test, anova, frequency and answer tree were used. The major findings resulted from this study were as following; First, it found that participants in horticultural activities of the older adults showed greater leisure satisfaction than non-participants. Second, the longer than 20 years in participating horticultural activities and attending the least 30 minutes horticultural activities a day, the higher leisure satisfaction. Third, participants in horticultural activities of the older adults showed greater life satisfaction than non-participants. Fourth, the attending time of horticultural activities a day and duration of participation in horticultural activities do not effect the life satisfaction. Fifth, there existed significant relation among daily participation in horticultural activities of the older adults, leisure satisfaction and life satisfaction. It was also found that participation in horticultural activities of the older adults facilitated the leisure satisfaction, it finally leaded to the life satisfaction.

임대아파트 유지관리를 위한 성장형 데이터베이스 모델에 관한 연구

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In making social sympathy about the drafting of a mid-long term of maintenance plan and the development of building maintenance database for technique support, the target of this study is rental apartments admitting a variety of objects to data model in maintenance. For the development of database in maintenance, it shows that the database model is possible for the references of AS-IS modeling and function model and continuous work analysis by function and process analysis. Also, the structure of model at this study will be applied in maintenance as well as construction needed the development of database. To get continuous growth in maintenance information, it has been necessary to take a standard of information in plan, design, construction, and management. After this, it would be required to develop the South Korea-type FMS(Facilities Management Classes) based on IFC(Industry Foundation Classes)

자치경찰제 모형개발을 위한 시도

정우열,이광수 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

Recognizing that the korean governments very important the necessary of autonomy police systems, this paper attempt to design the appropriate model development of autonomy police systems. First, it explores logical criteria which are applicable to the redistribution of authority to police. Second, it analyzed how the efforts to autonomy police systems have been exerted in 1990s and why these efforts have not achieved results. Based upon the analysis, this paper attempts to mutual cooperation and interactions between the central and local police, the enlargement of the citizen participations, the setting of the local police council, the coordination of the local tax and a raise of tax local shared tax.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

《漢園集》에 나타난 李廣田의 詩

鄭雨光 中國語文硏究會 1999 中國語文論叢 Vol.16 No.-

정밀어태치먼트의 완압정도에 따른 하악국소의치의 지지조직에 대한 3차원 유한요소 응력분석

정연진,우순섭,이영수,심광섭,유광희 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

The purpose of this study was to evaluate the stress distribution developed in the supporting structures by mandibular distal extension removable partial dentures with 4 different precision attachments. The examined precision attachments were Mini SG attachment, CM box attachment. Mini Dalbo attachment, Technoroach attachment. Concentrated force(vertical force 200N, horizontal force 50N) was applied on the artificial 2nd molar of the removable partial dentures and distributed force(vertical force 100N, horizontal force 25N) was applied on the each artificial 1st, 2nd molars of removable partial dentures. Total 4 cases were compared and analyzed with 3-dimensional finite element method. And then, stress distribution patterns were analyzed and compared. The results were as follows. 1. In case of concentrated force; Maximal stress distribution was showed on the alveolus under artificial 2nd molar and then, stress mainly distributed on the residual alveolus of the denture base. 2. In case of distributed force; Maximal stress distribution was showed on the distal alveolar crest of distal abutment, and then, stress mainly distributed on the alveolus of mesial and distal abutments. 3. The stress of residual alveolus of non rigid attachment was greater than that of rigid attachment. 4. The stress of abutments of rigid attachment was greater than that of non rigid attachment.

《楚辭》에 관한 綜合的 小考와 資料

鄭雨光 中國語文硏究會 1992 中國語文論叢 Vol.5 No.-

임대아파트 장기수선 대체안 검토를 위한 CAFM 시스템 개발

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

In the case of rental apartment. the special Quality continuously preservation administration business consist and saves up Long-term Maintenance expense voluntarily. Because business surrounding that this can control preservation administration business whole is possible. administration of repair work is easy. Do system development that introduce technique for long-term strategy establishment in CAFM by purpose. Estimation of system to develop is as following: Can reduce time that take in LCC calculation because approach automatically to information of necessary facility in LCC calculation and know repair time as is easy. It is possible that execute selection of item that is examined in long-term maintenance plan as efficient and correct. Priority injection of budget by facility deteriorated degree is consisted preferentially using FCI.

동양과 서양의 다리 놓기 : 다이왕수의 삶과 시 Dai Wangshu's Life and Poetry

鄭雨光 中國語文硏究會 2004 中國語文論叢 Vol.0 No.26

The purpose of this study is to illustrate the sources of influence, both the East and the West, in the poetry of Dai Wangshu 戴望舒(1905-1950). Basically, he, one of the members of the early Modernist School, opposed using the Western classical meters promoted by the Crescent School's "formalists" Wen Yiduo and Xu Zhimo, claiming instead that pure poetry can only be 'contemporary' by possessing the expression of mood perceived in modern life. Dai Wangshu's career as a poet can be divided into three stages, i.e. My Memory 我的記憶(Wode jiyi, 1929) as representative of his first stage, The Draft of Wangshu 望舒草(Wangshu cao, 1933) as second stage, and The Years of Disaster 災難的歲月 (Zainan de suiyue, 1948) as third stage. I argues that the quality of classical poetry, especially the tone and imagery of the late Tang dynasty, provides an excellent means of understanding Dai's poetry in each stage. Despite his voyages to Paris, Lyons, and Spain(1932-1935), we are able to see more emphasis upon the quality of classical poetry even in his poems of third stage, imparting to them a reflective, philosophical, and spiritual emotion. The best example of this focus is "The Rainy Alley" 雨巷("Yu xiang") written by Dai Wangshu probably in the summer of 1927. With its uncertain and fuzzy images, sad moods, mellifluous language, and accordant combinations of words, "The Rainy Alley" has often been quoted as positive proof of Dai's indebtedness to French Symbolism. The poem bespeaks the lonely traveler's deep frustration and endless despair in the rainy alley. Here, the rainy alley suggests the darkness and bitterness of reality in which the lonely traveler hopes to meet "a lilac-like girl nursing her melancholy." Despite Dai's repeated emphasis on sadness or desperate feelings throughout the poem, "The Rainy Alley" ironically exhibits dreamlike beauty, a suggestive lyricism elegantly condensed in fragrances, colors, and sounds. Therefore, what Dai wants to create in the poem is not a direct sorrowfulness but an indirect supernal beauty. Viewed in this light, it goes without saying that this theme and image is still the echo of the late Tang dynasty poetry. In conclusion, the poetry of Dai Wangshu was greatly influenced by literary movements both outside and within China: the French Symbolist poets and the American Imagists as well as Crescent School and Chinese Symbolist movement of the twenties. Although Dai's poetry filtered out the heavy esotericism and obscurity of the earlier "Symbolists," it inherited their suggestive use of symbols. Similarly, it filtered out the excessive sentimentality of the Crescent School, while inheriting its romantic lyricism. Eliminated the mechanical formality of the Crescent School, this later school inherited some of its musical qualities, such as tonal pattern, rhyme scheme, alliteration, and assonance. Therefore, in many ways, Dai's poetry originated in the balance between the Crescent School and the "Symbolists."