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성낙도,유성재,남기달,장기혁,한호규 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
기질(S) 화합물로 30종의 5,6-dihydro-2-trifluoromethyl-1,4-oxathiin carboxanilide 유도체들을 합성하고 벼 잎집무늬 마름병균(Rhizoctonia solani)과 밀 붉은 녹병균(Puccinia recondita)에 대한 항균활성(in vivo) 값(pI_50)을 측정하였다. (S)는 잘록병균보다 밀 붉은녹병균에 대하여 보다 큰 항균활성을 나타내었으며 두 종의 균에 대하여 3-methoxy, 11, 3-iso-propyloxy, 13 및 3-iso-propyl 치환체, 25가 제일 큰 활성을 보였다. 그리고 치환(X)-phenylcarbamoyl group의 변화에 따른 물리-화학 파라미터와 항균활성(pI_50)으로부터 구조-활성관계(SAR)를 검토 한 결과, 벼 잎집무늬 마름병균에 대하여는 공명효과에 따른 전자밀게(R<0)의 소수성이 큰(π>0) m-alkyl 치환기(X)가, 그리고 밀 붉은녹병균에 대하여는 분자 분극율(Sp.Po1.)과 분자의 음하전(ABSQ<0)을 위시하여 HOMO에너지(e.v.)가 클수록(HOMO<0) 높은 항균활성을 나타내었다. 또한, 전하-조절 반응에 의한 수용체-(S)간의 상호작용과 높은 활성발현 조건들이 검토되었다.(1998년 2월 3일 접수, 1998년 12월 1일 수리) New thirty derivatives of 5,6-dihydro-2-trifluoromethyl-1,4-oxathiin carboxanilide as substrate(S) were synthesized and their fungicidal activities in vivo against rice sheath blight(Rhizoctonia solani) and wheat leaf rust(Puccinia recondita) were examined. The structure activity relationships(SAR) between the activities(pI_50) and a physicochemical parameters of substituents(X) at the phenylcarbamoyl group were analyzed using the adaptive regression analysis method. The 3-methoxy, 11, 3-isopropyloxy, 13 and 3-isopropyl substituent, 25 as X on the phenylcarbamoyl group exhibited the most highest fungicidal activity against the two fungi. The fungicidal potency of the (S) against Puccinia recondita was higher than Rhizoctonia solani. In case of Rhizoctonia solani, the molecular hydrophobicity(π>0) and resonance effect(R<0) by meta-alkyl substitutents with electron donating were important factors in determining fungicidal activity. And the HOMO energy(HOMO>0), ABSQ, sum of absolute values of the atomic charges on each atom and specific polarizability(Sp.Pol<0) of (S) were significantly influential towards fungicidal activity against Puccinia recondita. The interaction between (S) and receptor against from the based on SAR studies proceeds through charge-control reaction, and conditions to show higher activity has been also discussed.
닭 성장 및 육질개선을 위한 수용성키토산의 사료첨가 급이효과
남기달 ( Kee Dal Nam ),한호규 ( Hoh Gyu Hahn ),조승주 ( Seung Joo Cho ),박길현 ( Gil Hyun Park ),김종태 ( Chong Tai Kim ) 한국키틴키토산학회 2008 한국키틴키토산학회지 Vol.13 No.1
The objectives of this study were (1) to investigate the effects of chitosan-based feed additive(CFA) on the growth performance, feed intake, feed conversion, carcass characteristics, and (2) to explore the composition of biochemical components and on the textural and microstructural properties growing-finishing broiler chickens. The body weight gain of chicken fed with CFA was increased about 18% when compared to than that of commercial feed group. The mortalities of chicken fed with CFA were reduced about 55% when compared to than that of commercial feed group. There were no differences between control and broiler chicken fed with CFA in chemical components. Among fatty acids, comparably higher contents of 16 : 0, 16 : 1, 18 : 1 ω9 and 18 : 1 ω7 were observed in broiler chicken fed with CFA. The texture of breast meat in broiler chicken fed CFA exhibited a higher value for storage modulus compared than that of control. The microstructure of breast muscle showed a great difference between control and broiler chicken fed with CFA. This result might be greatly related to the hardness of texture. As a result, this study may suggest that the CFA effectively increased the body weight and reduced the mortality of chicken, and the CFA may be useful in poultry industry as cost-effective and eco-friendly feed additives.
박경남,이진,이민호,함준수,이중달,기춘석,윤호주,류우진,한규섭,정태준 대한내과학회 1988 대한내과학회지 Vol.35 No.2
Bone marrow aplasia is a well known but uncommon complication in viral hepatitis. We report a case of aplastic anemia associated with chronic active hepatitis caused by the hepatitis B virus. This case is of a 41 year old male with chronic active hepatitis as confirmed by liver biopsy. He had been treated with bed rest, alimentation, and hepatotonics, but developed pancytopenia on the 19th hospital day. At that time, a bone marrow biopsy showed markedly decreased cellularity (less than 10%). Severe neutropenia persisted for 24 days and was associated with pneumonia. By the 60th hospital day, he had improved gradually and the hematological picture was restored. A second bone marrow biopsy was performed and revealed slightly decreased cellularity (30~40%) with restoration of granulocytic components. One month later, pancytopenia reappeared and a third bone marrow biospy showed moderate decreased cellularity. The patients has been treated with oxymetholone. He is now completely cured.
박경남(Kyung Nam Park),한동수(Dong Soo Han),민경랑(Kyung Ran Min),함준수(Joon Soo Hahm),이종철(Jong Chul Rhee),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),이중달(Jung Dal Lee),원치규(Chi Kyooh Won) 대한내과학회 1988 대한내과학회지 Vol.34 No.6
N/A Stomach cancer is the most common malignancy and one of the leading causes of death in Korea. It is now an unchallanged concept that the only practical way of improving 5-year survival rate in patients with stomach cancer lies in the treatment in its early stage. Thus, tremendous efforts including mass survey and screening programs have been made for the early detection of stomach cancer, especially in the 1960s. The authors reviewed 96cases of early gastric cancer (EGC) which had been confirmed by surgery and pathologic examination from March 1974 to July 1986 in Hanyang University Hospital. 1) The incidence of early gastric cancer was 6.6% of all gastric cancer and 15.8% of gastric resection for stomach cancer, and there was no annual difference in incidence of EGC. 2) The greatest prevalence was in 4th decade (32.3%) and male to female ratio was 2.2:1 with male preponderance. 3) The common sites were gastric angle (47.9%) and antrum (36.4%), and along the lesser curvature (69.8%). 4) The most frequently encountered types by macroscopic classification were type IIc and its variants, accounting for over 60% of the cases. 5) In 52cases (54.2%), the lesions extended to submucosa, while 44cases (45.8%) were confined to mucosa. The metastases to regional lymph nodes were detected in 1cases of mucosal cancer and 11cas of patients with submucosal cancer. 6) The size of the lesions varied from smaller than 1.0cm to larger than 5 cm but there was no statiscally significant difference between the size of the lesion and the depth of invasion or the lymph node involvement. 7) According to the histopathologic type by WHO classification, tubuloadenocarcinoma was most common (53.7%). 8) The preoperative diagnostic rates for early gastric cancer was 63.5% by fiberoptic endoscopy and 57.1% by double contrast radiography. 9) Follow-up studies were possible in 43cases, and 5yr-survival rate was 93.0%.
위염 및 소화성 궤양의 병인과 Campylobacter pylori 와의 상관관계에 관한 연구
박경남(Kyung Nam Park),기춘석(Choon Suhk Kee),김정목(Jung Mogg Kim),정용훈(Yong Hoon Chung),김경희(Kyung Hee Kim),조양자(Yang Ja Cho),서인수(Inn Soo Suh),고영혜(Young Hyeh Ko),이중달(Jung Dal Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A Campylobacter pylori (Cp) was investigated in connection with chronic gastritis and peptic ulcer by means of endoscopic biopsy, Cp was found in 7 of the 18 randomly selected normal persons and in 47 of the 72 patients with gastritis, duodentitis, or peptic ulcer. Differentiation between the normal persons and patients was made by subjective symptoms and endoscopy. However, according to the relationship between the occurrence of Cp and histological diagnosis of the patients, the control persons could be classified: 6 persons with normal histology and without Cp: 9 persons with active chronic gastritis (ACG), of which 7 persons had Cp: 3 persons with chronic gastritis (CG) and had no Cp. According to histological examination of the 72 patients, 7 were normal, 39 had ACG, 21 had chronic ulcer (CU). In the 39 ACG patients, Cp was isolated in 25 (64.1%) and demonstrated by Giemesa or Warthin-Starry silver stain in 32 (82.1%). In the 21 CG patients, Cp was isolated in 6 (28.6%) and seen in the tissue stain in 5 (23.8%). In the 5 CU patients, Cp was isolated in 5 (100.0%) ans seen in the tissue stain in 3 (60.0%). ~In the 7 patients with normal histology, Cp was isolated in one (14.3%) and seen in the tissue stain in one (14.3%). Therefore, Cp was detected in 47 (65.3%) biopsy samples of the 72 patients and zero (0%) of the 6 normal persons without inflammatory sings on the endoscopic or histologic studies (P< 0.005). These findings strongly implicate Cp as the cause of active chronic gastritis and chronic ulcer.