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Ohashi, Natsuko,Morino, Katsutaro,Ida, Shogo,Sekine, Osamu,Lemecha, Mengistu,Kume, Shinji,Park, Shi-Young,Choi, Cheol Soo,Ugi, Satoshi,Maegawa, Hiroshi American Diabetes Association 2017 Diabetes Vol. No.
<P>Adipose tissues considerably influence metabolic homeostasis, and both white (WAT) and brown (BAT) adipose tissue play significant roles in lipid and glucose metabolism. O-linked N-acetylglucosamine (O-GlcNAc) modification is characterized by the addition of N-acetylglucosamine to various proteins by O-GlcNAc transferase (Ogt), subsequently modulating various cellular processes. However, little is known about the role of O-GlcNAc modification in adipose tissues. Here, we report the critical role of O-GlcNAc modification in cold-induced thermogenesis. Deletion of Ogt in WAT and BAT using adiponectin promoterdriven Cre recombinase resulted in severe cold intolerance with decreased uncoupling protein 1 (Ucp1) expression. Furthermore, Ogt deletion led to decreased mitochondrial protein expression in conjunction with decreased peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein expression. This phenotype was further confirmed by deletion of Ogt in BAT using Ucp1 promoter-driven Cre recombinase, suggesting that O-GlcNAc modification in BAT is responsible for cold-induced thermogenesis. Hypothermia was significant under fasting conditions. This effect was mitigated after normal diet consumption but not after consumption of a fatty acid-rich ketogenic diet lacking carbohydrates, suggesting impaired diet-induced thermogenesis, particularly by fat. In conclusion, O-GlcNAc modification is essential for cold-induced thermogenesis and mitochondrial biogenesis in BAT. Glucose flux into BAT may be a signal to maintain BAT physiological responses.</P>
Satoshi Ugi,Hiroshi Maegawa,Katsutaro Morino,Yoshihiko Nishio,Toshiyuki Sato,Seiki Okada,Yasuo Kikkawa,Toshihiro Watanabe,Hiromu Nakajima,Atsunori Kashiwagi 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.4
Background: Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration. Methods: Twenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels. Results: AUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours. Conclusion: Our system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.
SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene
( Yasushi Omura ),( Yoshihiko Nishio ),( Tadashi Takemoto ),( Chikako Ikeuchi ),( Osamu Sekine ),( Katsutaro Morino ),( Yasuhiro Maeno ),( Toshiyuki Obata ),( Satoshi Ugi ),( Hiroshi Maegawa ),( Hiros 생화학분자생물학회 2009 BMB Reports Vol.42 No.4