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Kang, Minji,Heo, Ryeon,Park, Seojin,Mun, Seo-Yeong,Park, Minju,Han, Eun-Taek,Han, Jin-Hee,Chun, Wanjoo,Ha, Kwon-Soo,Park, Hongzoo,Jung, Won-Kyo,Choi, Il-Whan,Park, Won Sun The Korean Society of Pharmacology 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.4
To investigate the adverse effects of clozapine on cardiovascular ion channels, we examined the inhibitory effect of clozapine on voltage-dependent K<sup>+</sup> (Kv) channels in rabbit coronary arterial smooth muscle cells. Clozapine-induced inhibition of Kv channels occurred in a concentration-dependent manner with an half-inhibitory concentration value of 7.84 ± 4.86 µM and a Hill coefficient of 0.47 ± 0.06. Clozapine did not shift the steady-state activation or inactivation curves, suggesting that it inhibited Kv channels regardless of gating properties. Application of train pulses (1 and 2 Hz) progressively augmented the clozapine-induced inhibition of Kv channels in the presence of the drug. Furthermore, the recovery time constant from inactivation was increased in the presence of clozapine, suggesting that clozapine-induced inhibition of Kv channels is use (state)-dependent. Pretreatment of a Kv1.5 subtype inhibitor decreased the Kv current amplitudes, but additional application of clozapine did not further inhibit the Kv current. Pretreatment with Kv2.1 or Kv7 subtype inhibitors partially blocked the inhibitory effect of clozapine. Based on these results, we conclude that clozapine inhibits arterial Kv channels in a concentration-and use (state)-dependent manner. Kv1.5 is the major subtype involved in clozapine-induced inhibition of Kv channels, and Kv2.1 and Kv7 subtypes are partially involved.
Cytotoxic Effect of 7β-Hydroxycholesterol on Human NCI-H460 Lung Cancer Cells
Kang, Kyoung Ah,Chae, Sungwook,Lee, Kyoung Hwa,Park, Moon Taek,Lee, Su Jae,Lee, Yun Sil,Hyun, Jin Won Pharmaceutical Society of Japan 2005 Biological & pharmaceutical bulletin Vol.28 No.8
<P>The cytotoxic activity of 7β-hydroxycholesterol (7β-OHC) was evaluated on human NCI-H460 lung cancer cells. 7β-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7β-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G<SUB>1</SUB> hypodiploid (apoptotic) cells, and apoptotic body formation, as evidenced by flow cytometry and fluorescence microscope, respectively. Apoptosis was also associated with loss of mitochondrial transmembrane potential, and the activation of caspases 9 and 3. 7β-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis. On the whole, the results indicated that 7β-OHC inhibited the proliferation of NCI-H460 cells through apoptosis <I>via</I> caspase activation.</P>
Kang, Hyun-Jae,Oh, Il-Young,Chung, Jin-Wook,Yang, Han-Mo,Suh, Jung-Won,Park, Kyung Woo,Kwon, Taek Keun,Lee, Hae-Young,Cho, Young-Seok,Youn, Tae-Jin,Koo, Bon-Kwon,Kang, Won-Yu,Kim, Weon,Rha, Seung-Woon W.B. Saunders [etc.] 2012 European heart journal Vol.33 No.21
<P>In the previous COREA-TAXUS trial, a 6-month adjunctive use of celecoxib reduced target-lesion revascularization (TLR) without increased thrombotic risk. We aimed to confirm the effects of 3-month celecoxib in patients receiving drug-eluting stent (DES) implantation in the larger prospective, randomized trial.</P>
Highly size-controlled synthesis of metal nanoclusters by inert-gas condensation for nano-devices.
Kang, Il-Suk,Seo, Hyun-Sang,Kim, Deuk-Han,Lee, Taek-Yeong,Yang, Jun-Mo,Hwang, Wook-Jung,Ahn, Chi Won American Scientific Publishers 2010 Journal of Nanoscience and Nanotechnology Vol.10 No.5
<P>Metal nanoclusters were fabricated by inert-gas condensation in a sputtering reactor. From transmission electron microscopy, it was confirmed that copper nanoclusters with a high degree of monodispersity in size of about 5 nm were successfully produced. The conductance of the percolated nanocluster film was measured. In order to incorporate nano-scale arrangement characterizations in nano-devices being operated in air, aging experiments of the specimen after long time in air were carried. Negative temperature coefficient of resistance suggests that surface native copper oxide in core-shell structured nanoclusters was mainly responsible for the conductance, because copper oxide is known as semiconductor. After aged at higher than 100 degrees C, the conductance at room temperature didn't return to the original value. This irreversible phenomenon might be due to coarsening and/or coalescence of copper nanoclusters.</P>
Kang, Hee Young,Jeong, Young Sook,Oh, Jae Young,Tae, Sung Ho,Choi, Chul Hee,Moon, Dong Chan,Lee, Won Kil,Lee, Yoo Chul,Seol, Sung Yong,Cho, Dong Taek,Lee, Je Chul Oxford University Press 2005 The Journal of antimicrobial chemotherapy Vol.55 No.5
<P><I>Objectives</I>: Antimicrobial resistance and class 1 integrons found in <I>Escherichia coli</I> isolates from humans and animals in Korea were characterized.</P><P><I>Methods</I>: <I>E. coli</I> isolates were examined for susceptibility to antimicrobial agents. Integrase genes were amplified. Gene cassette regions for classes 1 and 2 integrons were amplified and sequenced. Conjugal transfer and Southern hybridization were performed to determine the genetic localization of class 1 integrons. The clonal relationship of <I>E. coli</I> isolates carrying an identical cassette array was analysed by PFGE.</P><P><I>Results</I>: Commensal <I>E. coli</I> isolates from animals were highly resistant to commonly used antimicrobial agents such as tetracycline, sulfamethoxazole, streptomycin, ampicillin and carbenicillin. Integrons were most prevalent in commensal <I>E. coli</I> isolates from poultry (44%), followed by clinical isolates from humans (33%), commensal isolates from swine (23%) and humans (13%). <I>dfrA17-aadA5</I>, <I>dfrA12-orfF-aadA2</I> and <I>aadA1</I> were found most frequently in <I>E. coli</I> isolates from humans, poultry and swine, respectively. Class 1 integrons were mostly located in conjugative plasmids. <I>E. coli</I> isolates carrying an identical cassette array were phylogenetically unrelated.</P><P><I>Conclusions</I>: The use of antibiotics is strongly associated with antimicrobial resistance. <I>E. coli</I> isolates from different sources may select a specific gene cassette by antibiotic selective pressure, which results in differences in class 1 integrons. The horizontal transfer of class 1 integrons through conjugative plasmids seems to be responsible for wide dissemination of a particular type of class 1 integron.</P>
Taek Jong Lee(이택종),Binod Prasad Luitel(루이텔 비노드),Kweon Heo(허권),Bong Jun Choi(최봉준),Won Hee Kang(강원희) (사)한국생물환경조절학회 2011 시설원예‧식물공장 Vol.20 No.4
본 연구는 칼륨의 독성에 따른 배추의 생육과 생리적 특성 그리고 형태적 변화를 관찰하기 위하여 수행하였다. 100mM의 칼륨 농도 처리구까지 전체적인 생육이 증가한 반면, 600mM 처리구에서 생육이 가장 저조하였다. 칼륨 처리 농도가 높을수록 N, P, K, 함량은 증가하였지만 Ca, Mg, Na 함량은 감소하는 경향을 보였으며 미량원소, Fe, Mn, Zn의 경우 100mM의 처리구에서 가장 높은 함량을 나타내었다. 생체중당 Chl a, b와 carotenoid 함량은 600mM에서 가장 많이 증가하였으나 증가한 엽록소 함량에 비해 광합성효율(Fv/Fm)은 처리구간에 차이가 없었고 CO₂ 동화율은 오히려 감소하였다. 이는 칼륨 과다에 의한 삼투스트레스의 결과로 기공의 퇴화와 CO₂ 동화능력과 밀접한 관계가 있는 것을 형태학적 관찰로 확인되었다. Total free amino acid의 경우 100mM 처리구까지 칼륨 처리 농도가 증가함에 따라 증가한 반면 600mM에서 급격히 감소하였다. 따라서 본 실험에서의 배추는100mM의 칼륨 농도까지는 긍정적인 효과가 있는 것으로 판단되었다. Overusing chemical fertilizers involves potassium accumulation in the soil, which can become a toxicity problem in agriculture. This study was conducted to investigate the effect of potassium (K) treatment on growth, physiological characteristics, and morphological changes using Chinese cabbage (Brassica rapa L. ssp. campestris). With high (600 mM) K treatment, the plant growth traits of leaf length, leaf area, and fresh and dry weight of shoots and roots decreased, whereas chlorophyll content increased. As the concentration of K increasing, total N, P, and K increased in leaves, but concentrations of Ca, Mg, and Na decreased. However, Mn, Fe and Zn contents were highest in 100 mM K treatment. Chlorophyll a, b, and carotenoids increased with increasing K concentration. Maximum photochemical efficiency (Fv/Fm) was not significant in the all treatments, whereas CO₂ assimilation decreased with increasing K level due to stomatal degradation. Total free amino acids increased with the 10 and 100 mM K but decreased at 600 mM K treatments. Therefore, the growth and physiological characteristics of Chinese cabbage ascertained that tolerance up to 100 mM K when grown with nutrient solution in pot culture.