Protective effect of chorioamnionitis on the development of bronchopulmonary dysplasia triggered by postnatal systemic inflammation in neonatal rats

Choi, Chang Won,Lee, Juyoung,Oh, Joo Youn,Lee, Seung Hyun,Lee, Hyun Ju,Kim, Beyong Il Nature Publishing Group 2016 Pediatric research Vol.79 No.2

<P><B>Background:</B></P><P>Prenatal or postnatal systemic inflammation can contribute to the development of bronchopulmonary dysplasia (BPD). We investigated whether prenatal intra-amniotic (i.a.) inflammation or early postnatal systemic inflammation can induce BPD in a rat model.</P><P><B>Methods:</B></P><P>One microgram of lipopolysaccharide (LPS) or vehicle was injected into the amniotic sacs 2 d before delivery (E20). After birth, 0.25 mg/kg of LPS or vehicle was injected into the peritoneum of pups on postnatal day (P)1, P3, and P5. On P7 and P14, peripheral blood (PB), bronchoalveolar lavage fluid (BALF), and lung tissue were obtained and analyzed.</P><P><B>Results:</B></P><P>Postnatal i.p. injections of LPS significantly increased neutrophil counts in PB and BALF on P7 and P14. Similarly, proinflammatory cytokine and angiogenic factor transcript levels were increased in the lung by i.p. LPS on P7. Alveolar and pulmonary vascular development was markedly disrupted by i.p. LPS on P14. However, pretreatment with i.a. LPS significantly negated the detrimental effects of postnatal i.p. LPS on PB and BALF neutrophil counts and on lung proinflammatory cytokine expression and histopathological changes.</P><P><B>Conclusion:</B></P><P>Exposure to early postnatal systemic LPS induces BPD, an arrest in alveolarization, in neonatal rats. Preceding exposure to i.a. LPS protects the lungs against BPD triggered by postnatal systemic inflammation.</P>

장소성의 맥락에서 지역디자인의 특성 연구 - 부산성(釜山性)의 관점에서 부산지역 디자인의 해석 -

장주영 ( Juyoung Chang ) 한국디자인트렌드학회 2017 한국디자인포럼 Vol.54 No.-

연구배경 본 연구는 장소성의 맥락에서 지역의 디자인의 특성을 분석하는 작업을 하고자 한다. 고도화된 기업의 산업 전략으로서의 디자인의 관점이 아닌 디자인을 인간의 삶과 밀착된 일상문화적 관점에서 보는 연구는, 상품화되고 타자화된 한국디자인의 표피적 겉모습에서 벗어나, 지역이 주체가 되는 실제적이고 성찰적인 한국디자인의 진면모인 정체성에 관한 것이라 할 수 있다. 연구방법 연구의 방법은 주로 문헌고찰과 사례연구를 중심으로 진행한다. 부산 디자인을 사회과학의 이론인 근접성의 원칙, 인간 지각적 특성, ANT와 길들이기 이론 등의 3가지 개념적 틀을 가지고 해석을 진행한다. 연구결과 일상의 디자인문화는 장소라는 맥락적 배경 하에서 그 속의 사람들에 의해 인공물이 생성되고 사람과 인공물과의 상호작용과 적응 과정을 통하여 근접성의 원칙과 미감과 정체성 등이 형성되어가는 것을 알 수 있었다. 부산지역은 특수한 역사적 자연적 환경 속에서 좁은 지역에서 부대끼면서 일상을 영위하면서 공적인 거리 감각은 개인영역에서 밀착되는 것에 익숙해졌고, 좁은 공간을 해소하기 위해 위로 쌓아올리는 형식에 친숙해졌다. 이로 인해 겹겹이 쌓아올려서 빈 공간 없이 빼곡한 구성과 형식을 선호하는 미감이 생성되었고, 오늘날 다양한 디자인 창작물과 물건의 진열방식에도 영향을 미치고 있음을 볼 수 있었다. 결론 장소성의 맥락에서 3가지 이론적 틀을 가지고 부산의 다양한 인공물에 대한 사례를 분석하여 부산의 일상의 디자인문화를 해석해보았다. 다양한 요소와의 관계가 복잡하게 연결되어 있는 일상의 디자인 문화를 장소성 맥락이라는 다각적인 관점에서 새롭게 해석하고 이해해 본 데에 본 연구의 의의를 둔다. 또한 중심부의 디자인 연구가 아닌 지역의 디자인에 대한 화두를 던져본 것에도 또 다른 의미를 둘 수 있겠다. Background This Research will present analytic approach to traits of local design in the context of place. The research will not focus on industrial strategic aspect of design from corporations but focus on the daily cultural aspect of the design tightly joined to human life. Thus, it is about practical and reflective identity of Korean design where the locality becomes a subject beyond its commercialized and otherized surface. Methods The research methods will involve reviews on the literature and case studies primarily. Moreover, law of proximity in terms of social science theory, perceptual characteristics of human beings, ANT, and domestication theory will take parts as conceptual frame in case studies to proceed with interpretation. Result It has been acknowledged that people in the place generate artifacts and the process of interaction and adaptation between people and artifacts create law of proximity and sense of beauty and identity through the daily design culture. Busan locally possesses specific historic and natural environment where people are used to lead daily lives by mingling around in limited space and to closely join together in personal territories in terms of public sense of distance. Also, this place is apt to build upwards in order to resolve issues from limited space. As a consequence, the sense of beauty in this place is dedicated to packed constructions and formations without wasting a space, which influences on its various design creations and display styles of objects today. Conclusion Throughout the research, the daily design culture in Busan has been interpreted with three theoretical schemes in the context of place. The research presents its significance on analyzing and understanding daily design culture where relationships with other elements are intricately connected in the multilateral context of place. Also, the research connotes another meaning by bring up the conversation on local design, not the central one.

한국 디자인 관련 학회에서 발간하는 학술지 현황조사

장주영(Chang Juyoung) 한국디자인학회 2012 한국디자인학회 학술발표대회 논문집 Vol.2012 No.5

한국 근대기의 공예상황

장주영(Juyoung Chang) 한국디자인학회 2013 디자인학연구 Vol.26 No.4

해외 주요 간행물에 나타난 지역연구로서의 한국 관련 디자인 연구의 경향 - 세계화와 지역화의 관점에서 한국디자인 정체성 담론의 방향성 고찰 -

장주영 ( Juyoung Chang ) 한국디자인트렌드학회 2017 한국디자인포럼 Vol.55 No.-

연구배경 본 연구에서는 해외 주요 일간지와 학술지에 나타난 지역연구로서의 한국디자인 연구의 경향을 알아보는 것을 일차적 목표로 하며, 이를 통해 세계화와 지역화의 관점에서 한국디자인의 정체성 담론의 방향성을 고찰해보고자 하였다. 연구방법 먼저 한국디자인사에서 전통과 정체성에 관한 담론들을 살펴보고, 이들의 한계점을 논의해본다. 그리고 해외로 눈을 돌려 세계 속에서 지역디자인과 국가디자인의 서사에 대해 조사를 하고, 최근의 지역디자인 담론의 경향에 대해서도 살펴본다. 그리고 최근 6년간 해외 주요매체와 학술지에 거론되는 한국디자인에 대한 기사와 연구의 내용과 경향을 정리 분석한다. 연구결과 전체기사 중 한국문화예술 관련 국내외 행사나 전시회 소식을 알리기 위한 기사들이 가장 많았다. 관련 전문가에 의한 전문성을 갖춘 기사는 2개 정도가 있었다. 대체로 한국문화에 대한 가벼운 내용을 다룬 기사가 대부분이었다. 해외 우수학술지에 실린 한국디자인 관련 논문들은 10편 밖에 없었고, 모두 한국인 연구자들이 논문의 저자들이었다는 점이 특이했다. 이를 미루어 아직까지 한국디자인에 대한 외국인 전문 연구가는 없는 것으로 여겨진다. 이 연구들은 해외에 한국디자인을 적극적으로 알리는 도구로서의 역할을 하고 있다. 결론 해외연구자들의 시각을 이해해보고자 하는 본 연구의 목적은 이루지 못했지만, 국내디자인 연구자들이 앞으로 세계와 소통하며 한국디자인 담론을 생성해나가야 할 것이라는 방향성을 찾을 수 있었다. 본 연구는 해외에서 한국 관련 디자인 연구의 현황을 조사 분석하여 세계적 지역적 관점에서 한국디자인의 정체성 담론의 방향성을 모색해본 것에 의의를 두며, 이를 계기로 초국가적 관점에서의 한국디자인 담론이 전 세계적으로 활발하게 확산되길 기대한다. Background The primary goal of this study is to examine trends in Korean design studies as a regional study in major foreign media and academic journals; and to examine the direction of the discourse of Korean design identity in terms of globalization and localization. Methods Firstly, the discourses on tradition and identity within Korean design were examined and their limitations were discussed. Subsequently, narratives of regional and national design in the world were investigated; as well as recent trends of regional design discourses. The articles and researches regarding Korean design which were mentioned in major overseas media and journals within the last six years were analyzed. Result Most articles introduced Korean design and arts related events and exhibitions. Other articles introduced Korean traditional culture and other innovative products. Majority of articles were rather light descriptions of Korean culture. There were only ten articles related to Korean design that had been published in acclaimed journals. Interestingly, all of these articles were written by Korean researchers. As a result, it seems that there are no foreign researchers on Korean design yet. These have been acting as a tool to actively promote Korean culture abroad. Conclusion The purpose of this study is to investigate the current situation of design research related to Korea from abroad and to examine the direction of discourse of identity of Korean design from a global and regional viewpoint. It is expected that the discourse of Korean design from the transnational perspective will be actively spread around the world.

정보기술을 활용한 전략격자 교차 분석 검증

김주영(Juyoung Kim),장근(Keun Chang),이병수(Byoungsoo Lee) 한국정보기술학회 2005 한국정보기술학회논문지 Vol.3 No.6

With the innovative development of computer technology, the combination of communication network gave new change to the corporation. Companies used this innovative information technology to get the better place in the competition in the market, and to acquire that. Therefore the importance of information technology is getting increased these days. With this kind of change in the situation business groups are located, they encountered the difficulty to develop, to set, and to maintain the information system, which can support the whole system. Through this process, there came out the need for the outsourcing of the information technology. Therefore we are to find out the type of outsourcing, the role of information technology, and the differences based on the level of information technology, and to go over the situation of outsourcing in Korea.

Two-photon fluorescence sensors for imaging NMDA receptors and monitoring release of Zn²⁺ from the presynaptic terminal

Chen, Xiaoqiang,Lim, Chang Su,Lee, Dayoung,Lee, Songyi,Park, Sang Jun,Kim, Hwan Myung,Yoon, Juyoung Elsevier 2017 Biosensors & bioelectronics Vol.91 No.-

<P><B>Abstract</B></P> <P>Synaptic Zn<SUP>2+</SUP> plays an important role in neurotransmission and a neuromodulator. The development of the imaging tools for monitoring spatiotemporal changes taking place in synaptic Zn<SUP>2+</SUP> concentrations is necessary in order to understand the role of Zn<SUP>2+</SUP> in the function of many aspects of the glutamate system. In this work, two-photon probes <B>1</B> and <B>2</B>, bearing ifenprodil-like tails that have affinity for NMDA receptors of neuronal cells, were designed and prepared. The two-photon fluorescent probe <B>1</B>, which bears (N-(6-acetylnaphthalen-2-yl)-N-methylglycine) as two-photon fluorophore, enables high resolution imaging of neuronal cells. The two-photon fluorescent probe <B>2</B>, which contains the di-2-picolylamine (DPA) as a Zn<SUP>2+</SUP>-binding site, the naphthalimide unit as the two-photon fluorophore, and the ifenprodil-like tail as the NMDA receptor binding moiety, can be employed for selective detection of Zn<SUP>2+</SUP> located near the NMDA receptor and for monitoring concentration changes of Zn<SUP>2+</SUP> in live neurons and hippocampal tissues.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Two-photon probes <B>1</B> and <B>2</B>, bearing ifenprodil-like tails that have affinity for NMDA receptors of neuronal cells, were designed and synthesized. </LI> <LI> Probe <B>1</B> can be used to image NMDA receptors in neuronal cells with two-photon microscopy. </LI> <LI> Probe <B>2</B> was able to sensitively monitor Zn<SUP>2+</SUP> located near NMDA receptors. </LI> <LI> Probe <B>1</B> and <B>2</B> can be successfully applied to image NMDA receptors in hippocampal tissues for two-photon fluorescence imaging. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Acquired Hemophilia A Combined with Systemic Lupus Erythematosus: A Case Report and Literature Review

( Juyoung You ),( Hojae Kim ),( Jin Su Park ),( Myung Hee Chang ),( Chan Hee Lee ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.5

Acquired hemophilia A (AHA) is a rare hemorrhagic disorder caused by autoantibodies against factor VIII (FVIII). An 80-year-old woman presented multiple bruises on her upper and lower extremities, along with gross hematuria. Extensive ecchymosis and swelling were observed on the buttocks. She had anemia and normal platelet count. The initial coagulation results showed prolonged activated partial thromboplastin time (aPTT, 68.5 seconds) and normal prothrombin time. According to the mixing test, we observed a decreased FVIII activity (2%), increased factor VIII inhibitor (FVIII-I) titer (74.4 BU), and negative lupus anticoagulant. AHA was diagnosed based on late onset bleeding and increased FVIII-I titer. Additionally, she met the criteria for systemic lupus erythematosus (oral ulcer, photosensitivity, renal disorder, and positivity for antinuclear and anti-β2-glycoprotein- I antibodies). She was started on oral prednisolone for FVIII-I eradication. Post-treatment, her bleeding tendency, aPTT (47.3 seconds), and FVIII-I titer decreased (1.24 BU), and FVIII activity increased (10%). (J Rheum Dis 2017;24:309-312)

깊은 합성곱 신경망 모델에 따른 유방 초음파 영상 분류 성능 비교

박주영(Juyoung Park),김이삭(Yisak Kim),유창완(Chang-Wan Ryu),김형석(Hyungsuk Kim) 대한전기학회 2021 전기학회논문지 Vol.70 No.1

Breast ultrasound has been widely utilized for classifying tumors into benignancy and malignancy. The limitations of traditional breast ultrasound are the handcrafted features obtained by well-trained sonographers and subjective decision according to different individual experiences. Recently, CNN-based deep learning techniques have exhibited better performance in medical images. However, most research for deep learning in medical ultrasound adopts CNN models developed for natural images due to the lack of common standard and dataset. In this paper, we compare six DCNN models which exhibit good performance for natural images - VGGNet, ResNet, InceptionNet, DenseNet, and EfficientNet. Our classification results demonstrate that CNN models of relatively lower performance on natural images show better performance on gray-scale ultrasound images and further study of CNN models are needed focusing on the features of medical images.

거짓말 탐지 검사관의 특징과 범죄자백율의 관계 분석

이창훈(Chang Hun Lee),송주영(Juyoung Song) 경찰대학 경찰학연구편집위원회 2011 경찰학연구 Vol.11 No.1

The aim of the current study is to investigate relationships between polygraph examiner's individual traits and confession rates. Prior studies of polygraph examination have been limited to investigate admissibility of polygraph evidence, reliability and validity of testing methods, and new technological developments. Particularly, in Korea, there has been no empirical study carried out to investigate possible effects of polygraph examiner's characteristics on performance of polygraph examination. To fill the vacuum of the literature, the current study examined effects of three socio-demographic variables(examiner's educational levels, experiences, and sex) on their performance(i.e., confession rates). Data utilized were collected from 107 seminar participants at the annual meeting of the American Polygraph Association in 2007. The findings showed that there were positive relationships between total years of experience in polygraph and confession rates, and between continuous specialized training and confession rates. Unexpectedly, the current study found that there were no significant relationships between educational levels and confession rates, and between total numbers of polygraph examination and confession rates. Finally, the current study did not find significant difference in confession rates across different gender groups. Based on the findings, four policy implications are discussed and suggested.