백혈병 세포에서 Multidrug Resistance Gene-1 (mdr1)의 과발현이 ^99m Tc-sestaMIBI 섭취에 미치는 영향

천경아,이재태,이상우,강도영,손상균,이종기,정준기,전수한,이규보 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: To determine whether 99mTc-MIBI is recognized by the multidrug resistant P-glycoprotein (Pgp), we have measured quantitatively 99mTc-MIBI uptake in cancer cells. The effects of various Pgp reversing agents on cellular 99mTc-MIBI uptake were also investigated in the presence of multidrug resistance gene-1(mdr1 gene) overexpression. Materisls and Methods: We measured percentage uptake of 99mTc-MIBI at different incubation temperatures both in mdr1 positive and negative cells. The effects of verapamil, cyclosporin, and dipyridamole on cellular uptake of 99mTc-MIBI were also evaluated with or withouts overexpression of mdr1 gene in Cultured murine leukemia L1210 cells. Results: The mdr1 gene expressing cell lines were effectively induced in in vitro with continuous application of low-dose adriamycin or vincristine. Cellular uptake of 99mTc-MIBI was higher in mdr1 negative L 1210 cells than those of mdr1 positive cells, and higher when incubated in 37℃ than 4℃. In the presence of verapamil, cyclosporin or dipyridamole, 99mTc-MIBI uptake was increased upto 604% in mdr1 positive cells. Conclusion: Cellular uptake of 99mTc-MIBI is lower in leukemia cells over-expressing mdr1 gene, and MDR-reversing agents increase cellular uptake. These results suggest that 99mTc-MIBI can be used for characterizing Pgp expression and developing MDR-reversing agents in vitro. (Korean J Nucl Med 1999;33: 152-62)

副腎皮質 腺腫을 同伴하는 原發生 Aldosteronism

이기형,전정열 慶熙大學校 1983 論文集 Vol.12 No.-

A 41-year-old-woman with hypertension and hypokalemia underwent adrenalectomy for primary aldosteronism, She was found to have and adenoma in right adrenocortical region on pathologic result. The diagnosis was made by finding low plasma renin activity, which could not be stimulated, and unsuppresable elevated plasma or urin aldosterone. The localization of an adenoma was accomplished by adrenal angioraphy, venography ultrasonogram, and CT. The CT was more helpful to identify the localization of the tumor than other radiologic studies. The patient was recovered completly from hypertension and hypokalemia after operation.

유전자 알고리즘을 이용한 에이전트 멀티캐스팅 기법

이기준,강경아,정채영 조선대학교 통계연구소 2000 統計硏究所論文誌 Vol.2 No.1

하나의 작업지점에서 그룹의 다름 멤버들에게 다중으로 데이터 전송하기 위하여 point-to-point네트워크의 multicast tree를 이용하여 구현할 수 있다. 이러한 최소화 Steiner tree를 사용한 multicast 기법은 그룹에 대하여 하나의 Steiner tree를 이용할 수 있다는 장점을 지니고 있다. 따라서 최소화된 Steiner tree를 작성하는 것은 NP-Complete 문제와 효율적인 알고리즘을 작성하는데 필수적인 문제이다. 본 논문에서는 최소화된 Steiner tree를 찾는 에이전트와 유전자 알고리즘에 대하여 기술하고자 한다. 에이전트는 노드들 사이의 가중치를 검사하고 유전자 알고리즘에 이를 전송하다. 그리고 유전자 알고리즘 이 가중치와 최적화 Steiner tree 검색작업을 시도하여 Steiner tree를 작성한다. 본 논문에서는 전형적인 유전자알고리즘에 적용된 이진 스트링(DNA)의 특징을 가진 트리기반의 genetic encoding 방법을 기술하고 이에 대한 유용성을 보이고자 한다. Multicasting transfer data from one point to the members of groups. which can be supported by using multicast tree in point-to-point network. For multicast routing a minimal steiner tree is used, and has an advantage in that only one Steiner tree is needed for a group. However, finding a minimal Steiner tree is an NP-complete problems and it is necessary to develop efficient heuristic algorithms. In this paper, we present agents and genetic algortihms for a finding minimal Steiner tree. Agents check weights among nodes and transmit these to genetic algorithms. Then, genetics algorithms build Steiner trees with these weights and try to find a optimal Steiner tree. This paper describes a tree-based genetic encoding scheme which is in sharp contrast with binary string representations usually adopted in conventional genetic algorithms, and shows the efficiency of this scheme through experiments.

高果糖 誘導 고지혈증 흰쥐에 대한 薏苡仁의 효과

이영종,손영종,임덕빈,이은섭,박중수,김성기 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective : In order to examine the effects of Coicis Semen on the hyperlipidemia, the extracts of Job's Tears were given to hyperlipidemic rats induced by fructose-rich chow. Method : The hyperlipidea was induced by fructose-rich chow during five weeks in rats. And the rats were administered with the extracts prepared from husk layer, bran layer, polished rice, unpolished rice or unhulled grain of Job's Tears each others during three weeks. And then, the effects of the extracts on body weight gain, total cholesterol, triglyceride and blood glucose were examined. Results and Conclusion : The extracts prepared from polished rice, unpolished rice or unhulled grain of Job's Tears had no effects on the body weight gains of the corpulent rats induced by a high fructose diet. Meanwhile, the extracts prepared from the unhulled grain (Coicis Semen), unpolished rice, and bran layer of Job's Tears decreased the levels of blood total cholesterol. and triglyceride, each others. And the effect of unhulled grain was more stronger than those of the others. The results suggested that unhulled grain had some materials useful for alleviating the hyperlipidemia, and the effective molecule is existed in the surface of unhulled grain.

한국인의 하악 구치의 근관 형태에 관한 후향성 연구

정일영,금기연,이승종,이찬영 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

A retrospective in vivo study of endodontically treated mandiblar molars was conducted. The radilographs and clinical records of mandibular molars that had been treated endodontically in the Dental hospital of Yonsei University from 1986 to July 1997 were reviewed and categorized. A total of 1751 cases were studied and following results were obtained. 1. The number of root canals in mandibular first permanent molar in d Korean population revealed three in 53.2%, four in 23.0%, two in 18.4%, C-shaped canal in 5.0%, and one in 0.4%. 2. In mandibular second molar, three canals was observed in 53.3%, four in 22.2%, two in 14.9%, C-shaped canal in 9.1%, and one in 0.6%. 3. In the results of the percentage of 4 canals of mandibular first molars at various age, before age 20, 37.7% was obtained whereas 19.3% after 30. 4. 7.94% of mandibular first molars examined were found to have three roots. 5. The mandibular second molar had C-shaped canals in 9.1%.

깨달음과 치유 : "그리스도 요법" 서설

이정기 연세대학교 신과대학 2004 신학논단 Vol.37 No.-

Fe-Ni-Co 저열팽창성 합금의 고온 변형 특성 및 열간가공에 따른 열팽창 거동 연구

이기안,박종혁,조봉현,남궁정,김문철 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.9

The high temperature deformation behavior and the effect of hot compression on the thermal expansion behavior of Fe-29Ni-17Co low thermal expansion Kovar alloy were investigated in the compressive temperature range of 900~1300℃ at the strain rate range of 25~0.01 sec.^(-1). The temperature (T) and strain rate (ε˙) dependence of the flow stress (σ_(0.7)) could be well described by hyperbolic sine law as ε˙= A [sinh(0.0084 σ)^(5.2018)] exp(-330.41/RT). Surface hot cracking and significant voids around grain boundary could be found at low temperature below 1000℃ and low strain rate (0.01 sec.^(-1)). Thermal expansion coefficient α_(30~400) generally increased with increasing compressive temperature. Moreover, α_(30~400) remarkably increased as strain rate decreased at high temperature above 1100℃. However the thermal expansion coefficient α_(30~400) of low compressive temperatures (900℃ and 1000℃) anomalously increased especially at high strain rates. Experimental results indicated that not only α phase appearance but also grain size had definite influence on the thermal expansion behavior with hot deformation. The correlation between microstructure and thermal expansion behavior of Kovar alloy were also discussed.

저열팽창성 Fe-29Ni-17Co 코바 합금의 고온균열 발생과 고온연성에 미치는 S 및 Mn의 영향

이기안,박종혁,조봉현,남궁정,김문철 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

The effect of S & Mn on the hot ductility of Fe-29Ni-17Co Kovar alloy and the mechanism of high temperature cracking occurrence were investigated. It has been found that the brittle intergranular fracture at high temperature cracking is closely associated with the sulfide along grain boundary. Experimental results showed, especially when the S content was high and the Mn content was free, that small cavities could be nucleated easily on FeS particles along grain boundary and propagated fast at high temperature. The hot ductility of Kovar alloy was drastically increased with the addition of Mn and it was also increased with decreasing S content. SEM and FE-SEM analyses showed that the Mn addition in this alloy could cause ductile intergranular fracture appearance below 1150℃ by the precipitation of MnS. It was proposed from the results that the addition of Mn and optimum S content (below 30 ppm) in Kovar alloy was necessary in order to reduce the hot cracking susceptibility.

Magnetron sputtering법으로 제조된 Al-1%Cu/Tungsten Nitride 다층 박막

이기선,서수정,김장현,김남철 공주대학교 자원재활용신소재지역협력센터 2000 2차년도 센터 사업 성과집 Vol.2000 No.1

표면 탄성파 디바이스의 전극재료로 사용되는 Al-1%Cu(4000Å)/tungsten nitride 박막을 magnetron sputtering법으로 제조하고 전기저항을 평가한 결과 비정질상의 tungsten nitride 박막을 제조할 수 있었고, 비정질 형성을 위해서 질소비 (R = N2/(Ar+N2))가 10∼40% 정도 필요하였다. Tungsten nitride 박막의 잔류응력은 비정질이 형성되면서 급격히 감소되었다. 이러한 비정질 박막위에 Al-1%Cu합금막이 형성되었다. 다층막은 453K에서 4시간 동안 열처리함으로써 3.6μΩ-cm의 저항를 나타냈는데, 이는 박막내 결정립 성장과 결정 결함의 감소에 기인하였다. As a power durable-electrode in SAW filter. Al-1%Cu/tungsten nitride multi-layer thin film was fabricated by magnetron sputtering process. Tungsten nitride films had the amorphours phase at the nitrogen ratio, R, ranging from 10~40%. The amorphization could be controlled by nitrogen ratio. R = N2/(N2+Ar) as a sputtering process parameter. Residual stress in tungsten nitride abruptly decreased with the formation of amorphous phase. Al-1%Cu thin film was deposited on the amorphous tungsten nitride. After the multi-layed thin film was annealed for 4 hours at 453K, the resistivity decreased as 3.6 μΩ-cm, which was due to grain growth and reduced crystal defects.

毛髮 및 爪甲의 성장에 따른 단백성분의 산화

정영도,최기오,양성렬,이춘기,안봉환,이민화 한국노화학회 1992 한국노화학회지 Vol.2 No.1