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RISS 인기검색어
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- 저자 : ( Joong Kyoung Ahn ) (검색결과 68 건)
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김영식,황성오,최경훈,안무업,오중환,임경수,윤정환,강성준 大韓應急醫學會 1992 대한응급의학회지 Vol.3 No.1
To evaluate the physiologic extent of pulmonary contusion and effect of PEEP therapy for pulmonary contusion, we studied 16 patients received PEEP therapy with pulmonary contusion from nonpenetrating chest trauma. Hemodynamic parameters including pulmonary vascular resistance index and intrapulmonary shunt fraction were calculated from standard measurement, and arterial oxygen tension was measured. Pulmonary vascular resistance index and intrapulmonary shunt fraction were increased in patient group. Arterial oxygen tension was decreased with increase of the intrapulmonary shunt fraction(R=0.75). Arter minimal PEEP therap(5-10 ㎝H₂O), pulmonary vascular resistance index was remained unchanged and intrapulmonary shunt fraction was decreased without significant changes of pulmonary hemodynamics. Increment of arterial tension was increased with decrease of intrapulmonary shunt fraction(R=0.43). Decreased stroke volume index suggested of cardiac injury such as cardiac contusion in patient group. These results of our study suggested that increased intrapulmonary shunt fraction caused arterial hypoxia in pulmonary contusion and arterial oxygen tension was increased as a result of reduced intrapulmonary shunt by PEEP therapy.
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Multi-physics Analysis for Temperature Rise Prediction of Power Transformer
Ahn, Hyun-Mo,Kim, Joong-Kyoung,Oh, Yeon-Ho,Song, Ki-Dong,Hahn, Sung-Chin The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.1
In this paper, a method for multi-physics analysis of the temperature-dependent properties of an oil-immersed transformer is discussed. To couple thermal fields with electromagnetic and fluid fields, an algorithm employing a user defined function (UDF) is proposed. Using electromagnetic analysis, electric power loss dependent on temperature rise is calculated; these are used as input data for multi-physics analysis in order to predict the temperature rise. A heat transfer coefficient is applied only at the outermost boundary between transformer and the atmosphere in order to reduce the analysis region. To verify the validity of the proposed method, the predicted temperature rises in high-voltage (HV) and low-voltage (LV) windings and radiators were compared with the experimental values.
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Ahn, Joong Kyong,Kim, Jungyeon,Hwang, Jiwon,Song, Juhwan,Kim, Kyoung Heon,Cha, Hoon-Suk Elsevier 2018 Joint, bone, spine Vol.85 No.3
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Although many diagnostic criteria of Behcet's disease (BD) have been developed and revised by experts, diagnosing BD is still complicated and challenging. No metabolomic studies on serum have been attempted to improve the diagnosis and to identify potential biomarkers of BD. The purposes of this study were to investigate distinctive metabolic changes in serum samples of BD patients and to identify metabolic candidate biomarkers for reliable diagnosis of BD using the metabolomics platform.</P> <P><B>Methods</B></P> <P>Metabolomic profiling of 90 serum samples from 45 BD patients and 45 healthy controls (HCs) were performed via gas chromatography with time-of-flight mass spectrometry (GC/TOF-MS) with multivariate statistical analyses.</P> <P><B>Results</B></P> <P>A total of 104 metabolites were identified from samples. The serum metabolite profiles obtained from GC/TOF-MS analysis can distinguish BD patients from HC group in discovery set. The variation values of the partial least squared-discrimination analysis (PLS-DA) model are R<SUP>2</SUP>X of 0.246, R<SUP>2</SUP>Y of 0.913 and Q<SUP>2</SUP> of 0.852, respectively, indicating strong explanation and prediction capabilities of the model. A panel of five metabolic biomarkers, namely, decanoic acid, fructose, tagatose, linoleic acid and oleic acid were selected and adequately validated as putative biomarkers of BD (sensitivity 100%, specificity 97.1%, area under the curve 0.998) in the discovery set and independent set. The PLS_DA model showed clear discrimination of BD and HC groups by the five metabolic biomarkers in independent set.</P> <P><B>Conclusions</B></P> <P>This is the first report on characteristic metabolic profiles and potential metabolite biomarkers in serum for reliable diagnosis of BD using GC/TOF-MS.</P>
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다발성 손상 환자에서 Abdominal CT Scan을 이용한 흉부손상의 진단
안무업,오중환,임경수,황성오,강성준 대한응급의학회 1991 대한응급의학회지 Vol.2 No.1
Injuries to the thorax was evaluated among 224 patients admitted to the emergency room with multiple trauma who had undergone abdominal CT scan for possible intraabdominal injuries. In order to detect possible intrathoracic injury, abdominal CT scan were sliced 1cm apart starting from a point 2cm superior to the diaphragm. Soft tissue and lung window were performed on cross sectional images 2cm, 1cm above the diaphragm and to the diaphragm level. Among the 224 patients with multiple trauma who had undergone abdominal CT scan, thoracic injuries previously undetected on plain chest X-ray were detected in 42 patients(18.8%) on the abdominal CT scan. 123 different thoracic lesions were found to present on the 42 patients diagnosed to have thoracic injuries on the abdominal CT scan, among which there were 67 cases of hemothorax, 24 cases of lung contusion, 24 SQ emphysematous lesions, 6 cases of pneumothorax, and chest wall hematoma in 1 patient. Among the 67 patients with hemothorax 21 patient(31.3%) and 4 patients(66.7%) among the 6 with pneumothorax eventually received closed thoracostomy, and 4 patients among the 24 with lung contusion received ventilator care following admission. In conclusion, when abdominal CT scan is performed for evaluation of suspected abdominal injuries with absence of thoracic injuries on plain chest X-ray, possible thoracic as well as abdominal lesions should be closely observed.
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안규중,김경진,이길주,양경미 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2
Background: Pityriasis versicolor is often found following pathologic transformation of Malassezia fungi from yeast to mycelial forms by a poorly understood mechanism and is characterized by squamous skin lesions manifesting hyper- or hypo-pigmentation. Itraconazole is a synthetic oral antifungal agent of triazole family, which acts as a selective inhibitor of the cytochrome P-450-dependent synthesis of ergosterol and is reported to demonstrate a potent antifungal efficacy against Malassezia yeasts. Object: The present clinical study was designed to evaluate the therapeutic efficacy of one-week regimen of itraconazole by studying 20 patients with pityriasis versicolor, who were diagnosed both clinically and mycologically. In addition, we wished to identify Malassezia species from skin lesions of pityriasis versicolor and examine the possible correlation of a certain Malassezia(M.) species and pityriasis versicolor. Methods: Twenty patients (ages, 18 to 49) were included in the study, following the diagnosis of pityriasis versicolor, which was based on clinical examinations and mycological studies (microscopy and culture). Patients received a single 200 mg dose of itraconazole (Sporanox^�) capsules daily with a full meal for one week. For all patients, clinical examinations and culture and microscopic studies were done before treatment, at the end of treatment, and 4 weeks later. Scales obtained from skin lesions were studied by Parker-KOH smear examination and culture studies to identify Malassezia yeasts. Cultures were done using agar media of Leeming & Notman. Results: By comparing skin lesions before and immediately after treatment, marked improvement was observed in 7 patients (35%) and moderate improvement in 12 patients (60%) among a total of 20 patients, and 1 patient (5%) showed no response. On the other hand, by comparing skin lesions examined before treatment and 4 weeks after completing medication, complete cure was observed in 13 cases (65%), marked improvement in 5 (25%), and moderate improvement in 2(10%). With culture studies before treatment, M. globosa, M. furfur, and M. restricta were isolated as a major fungal species in 18, 1, and 1 patients, respectively. Conclusion: The result suggested that administration of a single dose of 200 mg itraconazole(Sporanox^�) capsules daily for a week is a very effective treatment for pityriasis versicolor and also indicated that pityriasis versicolor is very closely related with the infection of M. globosa. [Kor J Med Mycol 4(2): 124-130]
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Ahn, Joong Kyong,Kim, Jungyeon,Hwang, Jiwon,Song, Juhwan,Kim, Kyoung Heon,Cha, Hoon-Suk MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.11
<P>Diagnosing Behcet’s disease (BD) is challenging because of the lack of a diagnostic biomarker. The purposes of this study were to investigate distinctive metabolic changes in urine samples of BD patients and to identify urinary metabolic biomarkers for diagnosis of BD using gas chromatography/time-of-flight–mass spectrometry (GC/TOF−MS). Metabolomic profiling of urine samples from 44 BD patients and 41 healthy controls (HC) were assessed using GC/TOF−MS, in conjunction with multivariate statistical analysis. A total of 110 urinary metabolites were identified. The urine metabolite profiles obtained from GC/TOF−MS analysis could distinguish BD patients from the HC group in the discovery set. The parameter values of the orthogonal partial least squared-discrimination analysis (OPLS-DA) model were <I>R</I><SUP>2</SUP><I>X</I> of 0.231, <I>R</I><SUP>2</SUP><I>Y</I> of 0.804, and <I>Q</I><SUP>2</SUP> of 0.598. A biomarker panel composed of guanine, pyrrole-2-carboxylate, 3-hydroxypyridine, mannose, <SMALL>L</SMALL>-citrulline, galactonate, isothreonate, sedoheptuloses, hypoxanthine, and gluconic acid lactone were selected and adequately validated as putative biomarkers of BD (sensitivity 96.7%, specificity 93.3%, area under the curve 0.974). OPLS-DA showed clear discrimination of BD and HC groups by a biomarker panel of ten metabolites in the independent set (accuracy 88%). We demonstrated characteristic urinary metabolic profiles and potential urinary metabolite biomarkers that have clinical value in the diagnosis of BD using GC/TOF−MS.</P>
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