Human papilloma virus associated primary vaginal adenocarcinoma

( Joohee Yoon ),( Sujung Oh ),( Jisun Lee ),( Sangil Kim ),( Hyuna Kim ),( Soyoung Im ),( Ahra Lee ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Modified Laparoscopic Sacrocolpopexy with Peritoneal Tunneling Method using tailored mesh

( Joohee Yoon ),( Jiwoo Lee ),( Jiyeon Hong ),( Sangil Kim ),( Jigeun You ),( Jinwhi Kim ),( Sungjong Lee ),( Younjee Chung ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

We proposed modified laparoscopic sacrocolpopexy with peritoneal tunneling method to minimize complication and to shorten learning curve. These case series are to represent our experiences about modified laparoscopic sacrocolpopexy with peritoneal tunneling method. We retrospectively analyzed nine patients with symptomatic post-hysterectomy vaginal vault prolapse who were treated by modified laparoscopic sacrocolpopexy with peritoneal tunneling method at the St. Vincent’s Hospital and the Seoul St. Mary’s Hospital. We performed laparoscopic sacrocolpopexy without full dissection and repair of peritoneum. We could minimize complications and suturing time by making peritoneal tunnel in place of full dissection and repairing of the peritoneum over retroperitoneal mesh. We could find a restoration of pelvic floor anatomy after surgery. During follow-up period, there was no report of recurrence. We conclude that modified laparoscopic sacrocolpopexy with peritoneal tunneling method is one of the effective treatment option for vaginal vault prolapse patients by minimizing complications and shortening suturing time to repair the peritoneum over mesh during conventional laparoscopic sacrocolpopexy.

Ex utero intrapartum treatment procedure in two fetuses with airway obstruction

( Joohee Lee ),( Mi-young Lee ),( Yeni Kim ),( Jae-yoon Shim ),( Hye-sung Won ),( Euiseok Jeong ),( Byong Sop Lee ),( Ki-soo Kim ),( Woo-jong Choi ),( Yoon Se Lee ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3

The ex utero intrapartum treatment (EXIT) procedure was introduced to reduce fetal hypoxic damage while establishing an airway in fetuses with upper and lower airway obstruction. Delivery of the fetal head and shoulders while maintaining the uteroplacental circulation offers time to secure the fetal airway. Here, we report two cases of EXIT procedure for fetal airway obstruction, which were successfully managed with extensive preoperative planning by a professional multidisciplinary team.

Ex Utero Intrapartum Treatment procedure in two fetuses with airway obstruction

( Joohee Lee ),( Mi-young Lee ),( Yeni Kim ),( Jae-yoon Shim ),( Hye-sung Won ),( Pil-ryang Lee ),( Ahm Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

The ex utero intrapartum treatment (EXIT) procedure was introduced to reduce fetal hypoxic damage while establishing an airway in fetuses with upper and lower airway obstruction. Delivery of the fetal head and shoulders while maintaining the uteroplacental circulation offers adequate time to secure the airway while preventing fetal hypoxia. Here, we report two cases of fetal airway obstruction that were successfully managed using the EXIT procedure, with extensive preoperative planning and under a professional multidisciplinary team. Case 1: A 32-year-old woman was referred to our institution at 20 weeks of gestation with a diagnosis of a fetal neck mass. Ultrasonographic and magnetic resonance imaging findings revealed a 8.5cm-sized huge lymphangioma with suspected upper airway compression. Delivery was accomplished by a cesarean section with the EXIT procedure at 38.3 weeks of gestation. The fetus was endotracheally intubated while maintaining uteroplacental circulation. The baby is now 18 months old and does not show any signs of developmental or cognitive delay. Case 2: A 31-year-old woman was referred to our institution at 21 weeks of gestation with suspected congenital high airway obstruction syndrome (CHAOS). Ultrasonography revealed symmetrically enlarged, hyperechoic, and homogeneous lungs with an inverted diaphragm, anteriorly displaced heart, and polyhydramnios, all of which were suggestive of CHAOS. The baby was delivered via the EXIT procedure at 38 weeks of gestation, and a tracheostomy was performed. The baby is now five months old and is developing normally.

Optical and Electronic Properties of SnO2 Thin Films Fabricated Using the SILAR Method

( Joohee Jang ),( Haena Yim ),( Yoon Ho Cho ),( Dong Heon Kang ),( Ji Won Choi ) 한국센서학회 2015 센서학회지 Vol.24 No.6

Tin oxide thin films were fabricated on glass substrates by the successive ionic layer adsorption and reaction (SILAR) method at room temperature and ambient pressure. Before measuring their properties, all samples were annealed at 500oC for 2 h in air. Film thickness increased with the number of cycles; X-ray diffraction patterns for the annealed SnO2 thin films indicated a SnO2 single phase. Thickness of the SnO2 films increased from 12 to 50 nm as the number of cycles increased from 20 to 60. Although the optical transmittance decreased with thickness, 50 nm SnO2 thin films exhibited a high value of more than 85%. Regarding electronic properties, sheet resistance of the films decreased as thickness increased; however, the measured resistivity of the thin film was nearly constant with thickness (3×10-4 ohm/cm). From Hall measurements, the 50 nm thickness SnO2 thin film had the highest mobility of the samples (8.6 cm2/(V·s)). In conclusion, optical and electronic properties of SnO2 thin films could be controlled by adjusting the number of SILAR cycles.

Establishing a colorectal cancer liver metastasis patientderived tumor xenograft model for the evaluation of personalized chemotherapy

Joohee Jung,Jisup Kim,Hyun Kyung Lim,Kyoung Mee Kim,Yun Sun Lee,Joon Seong Park,Dong Sup Yoon 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.4

Purpose: In order to suggest optimal anticancer drugs for patient-tailored chemotherapy, we developed a colorectal cancer (CRC)-liver metastasis patient-derived tumor xenograft (PDTX) model. Methods: Tissue obtained from a patient with CRC-liver metastasis (F0) was transplanted in a nonobese female mouse with diabetic/severe combined immune deficiency (F1) and the tumor tissue was retransplanted into nude mice (F2). When tumor volumes reached ~500 mm3, the F2 mice were randomly divided into 4 groups (n = 4/group) of doxorubicin, cisplatin, docetaxel, and nontreated control groups. The tumor tissues were investigated using H&E staining, terminal deoxynucleotidyl transferase dUTP nick end labeling assays, and immunohistochemistry. To determine where the mutant allele frequencies varied across the different passages, we isolated genomic DNA from the primary tumor, liver metastasis, and PDTX models (F1/F2). Results: The physiological properties of the tumor were in accord with those of the patient’s tumors. Anticancer drugs delayed tumor growth, inhibited proliferation, and caused apoptosis. Histological assessments revealed no observable heterogeneity among the intragenerational PDTX models. Target exon sequencing analysis without high-quality filter conditions revealed some genetic variations in the 83 cancer-related genes across the generations. However, when de novo mutations were defined as a total count of zero in F0 and ≥5 in F2, exactly prognostic impact of clone cancer profiling (EGFR, KRAS, BRAF, PIK3CA, NRAS, APC and TP53) were detected in the paired. Conclusion: A CRC liver metastasis PDTX model was established for the evaluation of chemotherapeutic efficacy. This model retained the physiological characters of the patient tumors and potentially provides a powerful means of assessing chemotherapeutic efficacy.

Effect of Dried Garlic Flesh and Dried Garlic Juice on Body Fat and Lipid Metabolism in 9-month-old Rats with Diet-induced Obesity

Yoon Jung Kang,Joohee Kim,Doram Kim,이현선,권오란,Mi Kyung Kim 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3

The aim of this study was to investigate the effects of dried garlic flesh and dried juice of garlic flesh on the body fat and lipid metabolism of 9-month-old rats with diet-induced obesity. For 8 weeks, the rats were fed either a control diet or experimental diets containing 3 or 5%(w/w) of dried, powdered garlic flesh or garlic juice. In our study, body weight gains and calorie efficiency ratios were the lowest in 5% dried garlic flesh treatment. Hepatic diacylglycerol acyltransferase (DGAT) activities were inhibited relatively to the control for the dried garlic flesh treatments. Fecal total lipid excretion, plasma total lipid,and triglyceride concentrations were significantly improved through the 5% dried garlic flesh treatment. In conclusion,garlic consumption reduced the body fat and improved lipid profile in rats. Especially, consumption of dried garlic flesh was turned out to be more effective than the intake of dried garlic juice.

Growth Pattern With Morbidities From Birth to 5 Years of Age in Very Low Birth Weight Infants: Comparison of the Korean National Network and National Health Insurance Service

Lim Joohee,Yoon So Jin,Shin Jeong Eun,Han Jung Ho,Lee Soon Min,Eun Ho Seon,Park Min Soo,Park Kook In 대한의학회 2022 Journal of Korean medical science Vol.37 No.20

Background: Long-term growth data of very low birth weight (VLBW) infants are currently collected in the Korean Neonatal Network (KNN) and National Health Insurance Service (NHIS) database. However, variance in the number of infants, check-up time, and check-up parameters led to decreased credibility of cumulated data. We aimed to compare the data on serial growth outcomes by major morbidities from birth to 5 years in VLBW infants between the KNN and NHIS databases. Methods: We combined the NHIS and KNN data of VLBW infants born between 2013 and 2015. The check-up times in the NHIS database were at 4–6, 9–12, 18–24, 30–36, 42–48, and 54–60 months of age, whereas in the KNN were at 18–24 months of corrected age and at 36 months of age. Result: Among 8,864 VLBW infants enrolled based on the birth certificates from the Statistics Korea, 6,086 infants (69%) were enrolled in the KNN, and 5,086 infants (57%) participated in the NHIS health check-up. Among 6,068 infants, 3,428 infants (56%) were enrolled at a corrected age of 18–24 months and 2,572 infants (42%) were enrolled at a chronological age of 33–36 months according to the KNN follow-up registry. However, based on the national birth statistics data, the overall follow-up rate of the KNN at 36 months of age was as low as 29%. The NHIS screening rate was lower at first (23%); however, it increased over time to exceed the KNN follow-up rate. Growth failure (weight under 10th percentile) at corrected ages of 18–24 months and 36 months were more common in the NHIS than KNN (42% vs. 20%, 37% vs. 34.5%). Infants with bronchopulmonary dysplasia and periventricular leukomalacia showed similar rates of growth failure at 2 years but varying rates at 3 years between the KNN and NHIS. Conclusion: By integrating the KNN and NHIS data indirectly at continuous time points according to morbidities, we found that there are discontinuities and discrepancies between the two databases among VLBW infants. Establishing an integrated system by patient level linking the KNN and NHIS databases can lead to better understanding and improved neonatal outcomes in VLBW infants in Korea.

공리설계를 이용한 반잠수식 모바일하버의 개념설계

이주희(Joohee Lee),윤성진(SeongJin Yoon),정현(Hyun Chong),이필승(Phill-Seung Lee) (사)한국CDE학회 2010 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2010 No.1

The axiomatic design principles are applied to the conceptual design of semi-submersible type mobile harbor (B1). The process of how the design of mobile harbor is elaborated, evaluated and improved from the very beginning is presented in this paper. The concept of mobile harbor is a functional harbor, which can move to a container ship anchoring out of ports in the deep water to load/unload containers on sea and transfer them to their destination ports. This floating system will innovate the maritime transport and distribution since it will greatly enhance the accessibility of super-sized container ships to existing harbors and harbors without enough infrastructures. Designing a mobile system which can perform the functions of traditional harbors on the floating system requires innovative ideas as well as rigorous validations of each sub systems. In order to enhance the chance of design success, we try to satisfy the design axioms in early stage of conceptual design. We use the zigzagging process for defining Functional Requirements (FR)-Design Parameters (DP) hierarchy due to the complexity of the system. In other words, we decomposed the complexity of the design by FR-DP hierarchy and reduced coupled design logically and systematically. This paper shows applicability of the axiomatic design principles to the field of ocean systems engineering.

Growth patterns of preterm infants in Korea

Lim, Joohee,Yoon, So Jin,Lee, Soon Min The Korean Pediatric Society 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.1

With advancements in neonatal care and nutrition, the postnatal growth of preterm infants has improved; however, it remains an issue. Accurate assessments of growth using a standardized reference are needed to interpret the intrauterine and postnatal growth patterns of preterm infants. Growth in the earlier periods of life can contribute to later outcomes, and the refinement of postnatal growth failure is needed to optimize outcomes. Catch-up growth occurs mainly before discharge and until 24 months of age, and very low birth weight infants in Korea achieve retarded growth later in life. Knowing an infant's perinatal history, reducing morbidity rates during admission, and performing regular monitoring after discharge are required. Preterm infants with a lower birth weight or who were small for gestational age are at increased risk of poor neurodevelopmental outcomes. Furthermore, poor postnatal growth is predictive of adverse neurodevelopmental outcomes. Careful monitoring and early intervention will contribute to better development outcomes and national public health improvements.