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[PB-0062] Isolation of soybean ARGONAUTE protein involved in seed coat color pigmentation
Jinwon Lee(Jinwon Lee),Gyu Tae Park(Gyu Tae Park),Hyun Jo(Hyun Jo),Jeongyun Ko(Jeongyun Ko),Junbeom Park(Junbeom Park),Jeong-Dong Lee(Jeong-Dong Lee),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0064] Isolation of Ab-rg rich saponin mutants from EMS-induced population in soybean
Junbeom Park(Junbeom Park),Jagadeesh Sundaramoorthy(Jagadeesh Sundaramoorthy ),Jinwon Lee(Jinwon Lee),Jeong-Dong Lee(Jeong-Dong Lee),Hak Soo Seo(Hak Soo Seo),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Park, Jinwon The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
This paper aims to assess the applicability of the Runge Kutta Discontinuous Galerkin-Direct Ghost Fluid Method to the internal explosion inside a water-filled tube, which previously was studied by many researchers in separate works. Once the explosive charge located at the inner center of the water-filled tube explodes, the tube wall is subjected to an extremely high intensity fluid loading and deformed. The deformation causes a modification of the field of fluid flow in the region near the water-structure interface so that has substantial influence on the response of the structure. To connect the structure and the fluid, valid data exchanges along the interface are essential. Classical fluid structure interaction simulations usually employ a matched meshing scheme which discretizes the fluid and structure domains using a single mesh density. The computational cost of fluid structure interaction simulations is usually governed by the structure because the size of time step may be determined by the density of structure mesh. The finer mesh density, the better solution, but more expensive computational cost. To reduce such computational cost, a non-matched meshing scheme which allows for different mesh densities is employed. The coupled numerical approach of this paper has fewer difficulties in the implementation and computation, compared to gas dynamics based approach which requires complicated analytical manipulations. It can also be applied to wider compressible, inviscid fluid flow analyses often found in underwater explosion events.
Jinwon Park 대한조선학회 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
This paper aims to assess the applicability of the Runge Kutta Discontinuous Galerkin-Direct Ghost Fluid Method to the internal explosion inside a water-filled tube, which previously was studied by many researchers in separate works. Once the explosive charge located at the inner center of the water-filled tube explodes, the tube wall is subjected to an extremely high intensity fluid loading and deformed. The deformation causes a modification of the field of fluid flow in the region near the water-structure interface so that has substantial influence on the response of the structure. To connect the structure and the fluid, valid data exchanges along the interface are essential. Classical fluid structure interaction simulations usually employ a matched meshing scheme which discretizes the fluid and structure domains using a single mesh density. The computational cost of fluid structure interaction simulations is usually governed by the structure because the size of time step may be determined by the density of structure mesh. The finer mesh density, the better solution, but more expensive computational cost. To reduce such computational cost, a non-matched meshing scheme which allows for different mesh densities is employed. The coupled numerical approach of this paper has fewer difficulties in the implementation and computation, compared to gas dynamics based approach which requires complicated analytical manipulations. It can also be applied to wider compressible, inviscid fluid flow analyses often found in underwater explosion events.
Bioactive Lipids and Their Derivatives in Biomedical Applications
( Jinwon Park ),( Jaehyun Choi ),( Dae-duk Kim ),( Seunghee Lee ),( Bongjin Lee ),( Yunhee Lee ),( Sanghee Kim ),( Sungwon Kwon ),( Minsoo Noh ),( Mi-ock Lee ),( Quoc-viet Le ),( Yu-kyoung Oh ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.5
Lipids, which along with carbohydrates and proteins are among the most important nutrients for the living organism, have a variety of biological functions that can be applied widely in biomedicine. A fatty acid, the most fundamental biological lipid, may be classified by length of its aliphatic chain, and the short-, medium-, and long-chain fatty acids and each have distinct biological activities with therapeutic relevance. For example, short-chain fatty acids have immune regulatory activities and could be useful against autoimmune disease; medium-chain fatty acids generate ketogenic metabolites and may be used to control seizure; and some metabolites oxidized from long-chain fatty acids could be used to treat metabolic disorders. Glycerolipids play important roles in pathological environments, such as those of cancers or metabolic disorders, and thus are regarded as a potential therapeutic target. Phospholipids represent the main building unit of the plasma membrane of cells, and play key roles in cellular signaling. Due to their physical properties, glycerophospholipids are frequently used as pharmaceutical ingredients, in addition to being potential novel drug targets for treating disease. Sphingolipids, which comprise another component of the plasma membrane, have their own distinct biological functions and have been investigated in nanotechnological applications such as drug delivery systems. Saccharolipids, which are derived from bacteria, have endotoxin effects that stimulate the immune system. Chemically modified saccharolipids might be useful for cancer immunotherapy or as vaccine adjuvants. This review will address the important biological function of several key lipids and offer critical insights into their potential therapeutic applications.
Jinwon Park,Cheon Il Eom,Jaegun Jo,Jaewan Kim,Sangho Byun,Taebong Eom 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I
A two-dimensional nano-displacement measuring system utilizing a combined optical and X-ray interferometer (COXI) was developed. The system consists of optical interferometers for twodimensional displacements and an X-ray interferometer. The X-ray interferometer was used to calibrate the nonlinearity of the optical interferometers. The X-ray interferometer can subdivide an optical interference signal with 0.2 nm linear scales. The measured nonlinearity of the heterodyne optical interferometer was less than 2 nm. The calibrated optical interferometers were used to measure two-dimensional nano-scale displacements, and the accuracy of the optical interferometers was enhanced to enable sub-nanometer measurements after the compensation.愧
Dominance of climate warming effects on recent drying trends over wet monsoon regions
Park, Chang-Eui,Jeong, Su-Jong,Ho, Chang-Hoi,Park, Hoonyoung,Piao, Shilong,Kim, Jinwon,Feng, Song Copernicus GmbH 2017 Atmospheric chemistry and physics Vol.17 No.17
<P>Abstract. Understanding changes in background dryness over land is key information for adapting to climate change because of its critical socioeconomic consequences. However, causes of continental dryness changes remain uncertain because various climate parameters control dryness. Here, we verify dominant climate variables determining dryness trends over continental eastern Asia, which is characterized by diverse hydroclimate regimes ranging from arid to humid, by quantifying the relative effects of changes in precipitation, solar radiation, wind speed, surface air temperature, and relative humidity on trends in the aridity index based on observed data from 189 weather stations for the period of 1961-2010. Before the early 1980s (1961-1983), change in precipitation is a primary condition for determining aridity trends. In the later period (1984-2010), the dominant climate parameter for aridity trends varies according to the hydroclimate regime. Drying trends in arid regions are mostly explained by reduced precipitation. In contrast, the increase in potential evapotranspiration due to increased atmospheric water-holding capacity, a secondary impact of warming, works to increase aridity over the humid monsoon region despite an enhanced water supply and relatively less warming. Our results show significant drying effects of warming over the humid monsoon region in recent decades; this also supports the drying trends over warm and water-sufficient regions in future climate. </P>
High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients.
Park, Sanghui,Choi, Yoon-La,Sung, Chang Ok,An, Jungsuk,Seo, Jinwon,Ahn, Myung-Ju,Ahn, Jin Seok,Park, Keunchil,Shin, Young Kee,Erkin, Ozgur Cem,Song, Kyung,Kim, Jhingook,Shim, Young Mog,Han, Joungho Gutenberg 2012 Histology and histopathology Vol.27 No.2
<P>The aim of this study was to evaluate the prevalence and prognostic role of increased gene copy number and protein expression of MET and EGFR in non-small cell lung cancer (NSCLC) patients. Samples were collected from 380 patients with surgically resected NSCLC, and fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) were performed. EGFR amplification and high polysomy (EGFR FISH-positive) were observed in 9.7% and 17.4% of the patients, respectively. EGFR was overexpressed (EGFR IHC-positive) in 19.2% of the patients. Neither EGFR FISH-positive nor EGFR IHC-positive status affected survival after resection. Increased MET copy number (MET FISH-positive by University of Colorado Cancer Center criteria) was observed in 11.1% of the patients (high polysomy, 8.7%; gene amplification, 2.4%). According to the Cappuzzo system, 7.1% of the patients were MET FISH-positive. MET FISH positivity was a negative prognostic factor, especially in patients with adenocarcinoma histology (p=0.040), female gender (p=0.010), old age (p=0.084), and EGFR FISH negativity (p=0.020) at the univariate level but not at the multivariate level. MET was overexpressed (MET IHC-positive) in 13.7% of the patients and associated with shorter overall and disease-free survival (p=0.010 and p=0.056, respectively). Multivariate analysis revealed that MET IHC-positive patients had a significantly increased risk of death (hazard ratio, 1.618; 95% confidence interval, 1.066-2.456; p=0.024). Increased MET copy number and MET overexpression are negative prognostic factors for surgically resected NSCLCs.</P>