소아청소년 복합만성질환자 수 및 진료비의 변화: 2011-2021년 건강보험청구자료 분석

오정윤,조수진,정진선,조진숙,박춘선 건강보험심사평가원 2023 HIRA RESEARCH Vol.3 No.2

Background: The number of children and adolescents has decreased by more than 3 million over the past 10 years. We analyzed changes in the number of children and adolescents with complex chronic conditions (CCCs) and their medical expenditures between 2011 and 2021. Methods: We used National Health Insurance claims data of patients under the age of 20 from 2011 to 2021. CCCs were classified as pediatric CCCs by Feudtner et al. Patients who repeatedly utilize medical services due to CCCs were defined as patients who sought medical care twice or more within the past 3 years. Their sex, age, CCC categories, and the number of CCC categories were presented using descriptive analyses. Results: The number of children and adolescents with CCCs increased from 345,320 (3.04%) in 2011 to 451,238 (5.33%) in 2021. Patients who repeatedly utilized medical services due to CCCs increased by 71,889 during the same period. The proportion of patients with two or more CCC categories increased from 35.80% in 2011 to 43.67% in 2021. In 2021, patients with other congenital or genetic defect were most common. Medical expenditures associated with CCCs increased from 475,654 million won (12.34%) in 2011 to 768,467 million won (19.11%) in 2021. Conclusion: The number of patients with CCCs and their medical expenditures increased in Korea between 2011 and 2021. The results indicate that consistent national efforts are required to maintain the specialized pediatric care. Further studies are needed to identify pediatric patients who require specialized medical services through various methods.

어린이 공공전문진료센터의 진료 역량: 상급종합병원과의 비교를 중심으로

오정윤,조수진,정진선,조진숙,박춘선 건강보험심사평가원 2022 HIRA RESEARCH Vol.2 No.2

Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

한국인의 언어의식 : 언어접촉과 관련된 사회언어학적 연구

조준학,박남식,장석진,이정민 서울대학교 어학연구소 1981 語學硏究 Vol.17 No.2

The present study is an attempt to provide a rough profile of lingustic consciousness, as reflected in the day-to-day use of present-day Korean. The underlying assumption throughout is that the drastic socio-political changes in post-Liberation Korea must have left strong imprints in the popular Korean psyche and that there must be linguistic reflexes for these imprints, The present study does indeed come up with an interesting assortment of linguistic changes attributable to such socio-political changes as ① the coming of democracy and the nuclear family and ② an ever increasing encounter with other dialects and languages. As such, the present study can serve as a basis for a systematic formulation of language policy or for a principled 'purification' of Korean. A 50-item questionnaiare is used for the present study. The 784 respondents range from middle-school students to college graduates and represent both sexes and most of the major dialects of Korean.

한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.

낙농의 경영효율성과 경영개선 방안에 관한 연구

조석진,김창호 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.1

Dairy farm efficiency was estimated by data envelopment analysis(DEA) method using farm records surveyed over '94∼'97. The results revealed that dairy farm efficiency was lowered over '94∼'96 and turned upward in 1997 but fell short of the level in 1994. This implies that the various efforts to enhance the dairy farm efficiency in the post Uruguay Round period were not necessary successful. In addition, it turned out that dairy farm efficiency can be better ameliorated by eliminating inefficiency than by scale expansion.

Ⅱ급 부정교합자에서 액티베이터 사용에 따른 atlas의 위치 변화에 관한 연구

조문기,이진우,차경석,정동화 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.1

본 연구는 Ⅱ급 부정교합자에서 액티베이터 사용 후, 하악골의 변화에 따른 atlas의 위치 및 형태 변화를 조사하고, 그에 따른 치료 효과를 예측해 보고자 시행하였다. 실험군으로 Ⅱ급 부정교합자로써 액티베이터 치료를 시행한 경우 1군(총30명, 남자 15, 여자 15명), 대조군들로 Ⅱ급 부정교합자로 액티베이터 치료를 받지 않고, 교정치료를 받은 2군(총 22명, 남자 12, 여자 10)과 Ⅰ급 부정교합자로 치료를 받은 환자 3군(총 22명, 남자 12, 여자 10)으로 총 세 개의 군으로 나누었다. 치료 전(T1), 액티베이터 사용 중지 및 치료 중간시기(T2), 치료 종료(T3)시의 측모두부방사선사진을 통해서 골격 형태 계측 및 atlas 형태 계측을 시행하였다. Ⅱ급 액티베이터 사용 결과 액티베이터를 사용하지 않은 Ⅱ급 부정교합자 군에 비해 치료 종료 시 다음과 같은 계측치 들에서 골격적인 효과가 나타났다: ramal height, body length와 effective body length는 증가하였고, ANB는 감소하였다. Overjet은 두 군 사이에서 액티베이터 사용 후 유의한 감소가 일어났으나, 치료 종료 시에는 유의한 변화가 없었다. 세 군 모두에서 FH에 대한 atlas의 시계방향 회전이 나타났으나, 실험군 1군에서 대조군 2, 3군에 비해 유의하게 atlas가 FH에 대해 시계방향 회전되는 결과가 나타났다. 1군이 3군에 비해서 atlas의 유의한 후방이동을 보인 것을 제외하고는 세 군 사이의 atlas의 전, 후방적 위치나, 형태의 크기 변화에 있어 유의한 차이점은 없었다. 위의 결과들을 고려해 볼 때 atlas의 장축의 시계방향 회전은 액티베이터의 사용 효과로 생각되며, 이는 차후 Ⅱ급 부정교합자에서 액티베이터 치료 효과를 판단하는 또 하나의 지표가 될 수 있다고 생각한다. Objective: Previous studies have reported that morphological features of the first cervical vertebra(atlas) have been associated with mandibular growth direction. The purpose of this study was to show the possible positional and morphological changes of the Atlas from activator treatment in Class Ⅱ malocclusion patients. Methods: Lateral cephalometric radiograph tracings were made at initial, middle and final stages of treatment. Angular and linear measurements of skeletal and morphological features were measured on the anatomical landmarks and reference planes. Results: The skeletal effects of activator treatment on Class Ⅱ malocclusion patients were evident on ramal height, body length, effective body length, ANB, and overjet. Clockwise rotation of the long axis of the Atlas was found in Group 1, but there was no inclination change of the Atlas in groups 2 and 3. There was no significant correlation between anterior and posterior positions of the atlas or morphological change in all groups. - except for posterior movements of the Atlas found in group 1. Conclusion: Clockwise rotation of the atlas axis resulted from activator treatment in CI Ⅱ malocclusion patients. Change in atlas axis can be thought of as an indicator for success of activator treatment.

연근속의 Niacin 분석에 관한 연구

조인호,정석진 全北大學校 基礎科學硏究所 1981 基礎科學 Vol.4 No.1

Niacin contents in Lotus Corniculatus L. has been determined by high pressure liquid chromatography(HPLC), microbiological assay and manual chemical methods. It is concluded that the HPLC method was more precision than microbiological assay, or manual chemical methods.

전기화상후 Prostaglandin F2a와 Thromboxane B2의 증가에 대한 Flurbiprofen, Prednisolone 및 Gabexate mesilate의 억제효과

조병채,김인규,변진석,백봉수 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

This study was conducted to clarify the inhibitory effect of flurbiprofen, prednisolone, and gabexate mesilate on the synthesis of prostaglandin F2a and thromboxane B2 in the tissue of electrical burn. one hundred sixty Sprague-Dawley rats, 250gm of body weight in average, were divided into 4 groups of control, flurbiprofen, prednisolone and gabexate mesilate administred group. Fourty rats of the each group were subdivided into 1st, 2nd, 4th, 7th postburn day with 10 rats in each subgroup. Ten rats were used for normal values of prostaglandin F2a and thromboxane B2. Flurbiprodfen 30mg/kg was given per mouth, and prednisolone acetate 5mg/kg and gabaxate mesilate 50mg/kg were administred intramuscularly 5 minutes after burn injury and then once a day. All but bone tissue of within 2cm area of the current entry were harvested and ground into homogenate. The levels of prostaglandin F2a and thromoboxane B2 were measured by Radioimmunoassay. The results were as followings: In normal rat tissue, the level of prostagland F2a and thromboxane B2 were 15.8±1.8 and 17.6±2.8ng/mg protein in each. In the control group the levels of both prostaglandin F2a and thromboxane B2 increased abruptly to 5 times and 7 thimes in the first day and maintained the same level in the second day. After then they rapidly decreased and returned to a near normal level in the fourth day. The increase of thromboxane B2 was more remarkable than that of prostaglandin F2a. In the flurbiprofen group, the level of thromboxane B2 was not inerease but kept at a normal level. The average level of prostaglandin F2a in the post-burn first and second day was 59.5% lower than of the control group. The average level on the post-burn first and second day was 61% lower in thromboxane B2 and 33% lower in prostaglandin F2a in the prednisolone group, and 68% lower in throboxane B2 and 48% lower in prostaglandin F2a in the gabexate mesilate group, compared to the control group. These findings suggest that electrically injured tissue is vigrously progressive due to rapid increase of thromboxane B2 and prostaglandin F2a, as inflammatory mediators, in the post-burn first and second day, is nonprogressive after the post-burn fourth day. The flurbiprodfen was the most effective of the three drugs(flurbiprofen, gabexate mesilate, prednisolone in order of effectiveness) to suppress the synthesis of thromboxane B2 prostaglandin F2a of the electrieally injured tissue.

강원도산 감자의 품질 개량을 위한 연구 1.재배종 감자 품종들의 단백질, 환원당, 총폐놀성화합물 함량 및 Lipoxygenase Isozyme류 활성

조진숙,김화영,조순영 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.9 No.2

In order to develop potatoes with good processing qualities, we determined the protein content, reducing sugar content, total phenolic compounds content, and lipoxygenases activities in the tubers of five cultivated potato varieties. Superior variety contained the highest protein content among the five tested potato varieties. In addition, the reducing sugar content of Superior was lowest as compared with those of the five tested potato varieties. The lipoxygenase-2 activities of Superior and Chopung varieties were higher than those of Atlantic, Daegwan No. 52, and Daegwan No. 53 varieties. The five tested varieties showed no difference in the content of total phenolic compounds. The results suggest that Superior is the most acceptable material for processing such as potato chips and French fries.