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      • 알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

        이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

        To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

      • SCOPUSKCI등재
      • KCI등재
      • KCI등재후보

        Catecholamine 길항제 및 morphine 길항제 투여시 GABA 동작성약물이 진통효과에 미치는 영향에 관한 연구

        함진숙,송형근,김중수,이종흔 대한구강생물학회 1989 International Journal of Oral Biology Vol.13 No.2

        This experiment was performed to study the GABAergic function in descending analgesic mechanisms from periaqueductal gray matter and to clarify the relationship of GABA to noradrenaline or opioids. Sprague-Dawley rat was anesthetized and cannula was inserted into femoral vein for injection of yohimbine, catecholamine antagonist and naloxone, opioid antagonist. A pair of stimulating electrodes were inserted into palatal mucosa and anterior belly of digastric muscle was exposed and a pair of electrodes were inserted into muscle to assess the EMG of digastric muscle. The threshold intensity of the noxious stimulus which induced the minimal dEMG activity was established and twice as much stimulus as the threshold value was applied to oral mucosa. PAG was stimulated with 200μsec duration, 200Hz frequency for 200msec and jaw opening reflex was evoked by stimulation of palatal mucosa with 30msec delay after offset of PAG stimulation. The inhibitory effects of PAG stimulation on dEMG were evaluated. Muscimol (62.5ng) was infused in 5μl saline by ICV method. Naloxone (0.8mg/kg) or yohimbine (2mg/kg) was administered 15min after completion of muscimol injection by IV method. The dEMG was recorded at 15min interval for 2 hrs. The dEMG was decreased after muscimol was injected, and the dEMG of PAG-stimulated rat was increased to the control value after naloxone or yohimbine only was injected. After muscimol injection, injection of yohimbine or naloxone antagonized synergistic effect of muscimol on PAG stimulated effect.

      • 지문과 정신분열증

        우숙희,정국동,최송표,조근자,양은진,김수일,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

        Fingerprint patterns of 333 schizophreniacs who met with the diagnostic criterias of International Pilot Study of Schizophrenia except items associated with chronicity in exclusion criteria were studied, and the following results were obtained. 1. The frequency distribution of the fingerprint patterns in the 333 schizophreniacs was ulnar loop, whorl, twinned loop, arch, radial loop in order in both control and schizophrenia groups. 2. Finger ridge counts of both sexes were decreased significantly in schizophrenia group. 3. Dissociation of fingerprint pattern in the schizophrenia group was 51.1%, which was far greater than 6.25% of control group. Number of dissociation was greatest in the thumb, followed by index, middle, ring, and little finger in order. According to the above results, it is considered that both the number of finger ridges and degree of dissociation of fingerprint patterns were closely related with schizophrenia. Analysis of fingerprints and palmprints with the aid of chromosomal analysis would contribute the early diagnosis and prevention of schizophrenia.

      • KCI등재

        부모와 교사간의 연계교육 및 유아-교사간의 상호작용의 질에 따른 유아의 적응에 대한 연구

        손인숙,송진숙 한국영유아보육학회 2004 한국영유아보육학 Vol.0 No.39

        본 연구는 유아의 변수인 유아의 성별, 연령, 이전의 교육경험유무와 교사의 변수인 교사의 연령과 교사경력 등의 변수, 부모와 교사간의 연계교육과 유아와 교사간의 상호작용의 질에 따른 유아 적응의 차이를 알아보기 위하여 실시되었다. 본 연구의 대상은 전라북도 익산시와 전주시 그리고 군산시 소재 11곳의 유치원에 재원중인 아이를 둔 부모 612명과 교사 37명을 대상으로 실시하였다. 본 연구결과는 첫째, 유아의 적응에 있어 전반적으로 여아보다 남아가 유치원 적응을 잘하고 있는 것으로 나타났고, 이전 교육경험 유무에서는 전반적으로 이전 교육경험이 없는 유아보다 교육 경험이 있는 유아가 잘 적응하는 것으로 나타났다. 둘째, 교사의 특성에 따른 유아의 적응의 대한 결과는 교사가 30세 이하이고, 교사경력이 10년 이하일 때 유아가 안정성 측면에서 적응을 잘 하는 것으로 나타났다. 셋째, 부모와 교사간의 연계교육이 잘 수행될수록 유아의 적응이 잘 되는 것으로 나타났다. 넷째, 교사와 유아간의 상호작용의 질에 따라서는 교사-유아간의 상호작용의 질이 높을수록 유치원에서 유아의 적응이 잘 이루어지는 것으로 나타났다. The purpose of this study was to 1) investigate the differences between teacher and child's relationship, parent-teacher's partnership. 3) and its related variables - age of child, gender of child, educational experience of teacher, and so on - in kindergarten. Subjects were 612 parents and 37 teachers in Iksan, Junju, and Gunsan. The mean, percentile, t-test, and one-way ANOVA, were used. The results were as follows: First, there were significant difference among age of child, gender of child, and prior experience and child's adjustment in kindergarten. Second, there was significant difference between educational experience of teacher, age of teacher and child's adjustment in kindergarten. Third, there was significant difference between parent-teacher partnership and child's adjustment in kindergarten. Fourth, there was significant difference between child-teacher relationship and child's adjustment in kindergarten.

      • 77K에서 SC(NH₂)₂의 ¹⁴N 핵사중극 공명연구

        최숙자,박영민,박현진,전인,송승기,서용문 명지대학교 자연과학연구소 1997 자연과학논문집 Vol.16 No.-

        강유전체 질소화합물 thiourea [SC(NH₂)₂]분말시료의 ??plused NQR 실험을 77K 에서 실행하여 공명진동수와 핵사중극 결합상수, 비대칭인자, 완화시간등을 측정했으며, 4개의 공명선이 관측되었다. 결정내에는 주위 환경이 다른 두 종류의 질소 N₁,N₂가 존재함을 알 수 있었다. N₁에 관한 공명진동수는 ??(1)=2.6487㎒, ??(1)=2.032㎒, N₂에 대하여는 ??(2)=3.1852㎑, ??(2)=2.0183㎒이고, 공명선폭은 ??(1)=2.6752㎑, ??(1)=3.1852㎑, ??(2)=3.2618㎑, ??(2)=3.5448㎑ 임을 보였다. 한편 e²qQ/h의 값은 ν(1)에서 3.1205㎒, η는 0.3953이었으며, ν(2)에서는 3.0279㎒, 0.3939이었다. 이는 이미 보고된 결과와 일치하였다. 그리고, FID(Free Induction Decay)와 spin-echo실험을 통하여 얻은 스핀-격자 완화시간 T₁은 ??(1)에서 7.143 s, ??(2)에서 5.88 s이었으며, 스핀-스핀 완화시간 T₂는 ??(1)에서 25㎳, ??(2)에서 33.3㎳, ??(2)에서 33.3㎳의 값을 얻었다. We have measured ??N NQR frequencies, nuclear quadroupole coupling constants, asymmetric parameters and relaxation times in ferroelectric nitrogen thiourea [SC(NH2)2] at 77K, and four NQR resonance lines were observed. The results of measurements show that there are two kinds of nitrogen site, N1 and N2, with different environments in the crystal. The resonance frequencies were found to be ν+(l)=2.64 87MHz, ν_(1)=2.032 MHz for N1 and ν+(2)=2.6285MHz, ν_(2) =2.0183MHz for N2 respectively. The corresponding linewidths were ν+(1)= 2.6752kHz, Δν_(l) =3.1852kHz, ν+(2) =3.2618kHz and Δν_(2) =3.5448kHz, respectively. For N1, e2Q/h is 3.1205 MHz and η is 0.3953, and for N2, these are 3.0979MHz and 0.3939. These results are in agreement with those reported previously. The spin-lattice relaxation time (Ti) and the spin-spin relaxation time (T2) by FID and spin-echo experiments are as follows : T1(ν+(1)) is 7.143 s and T1(ν+(2)) is 5.88 s. T2(ν+(1)) is 25 ms, T2(ν_(1)) is 25 ms, T2(ν+(2)) is 33.3 ms and T2(ν_(2)) is 33.3 ms.

      • KCI등재

        일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

        하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

        연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.

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