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Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice
( Jin Imai ),( Takashi Yahata ),( Hitoshi Ichikawa ),( Abd Aziz Ibrahim ),( Masaki Yazawa ),( Hideaki Sumiyoshi ),( Yutaka Inagaki ),( Masashi Matsushima ),( Takayoshi Suzuki ),( Tetsuya Mine ),( Kiyo 대한장연구학회 2020 Intestinal Research Vol.18 No.2
Background/Aims: Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability to induce not only the expression of extracellular matrix (ECM) including collagen, but also the production of plasminogen activator inhibitor-1 (PAI-1) that prevents enzymatic degradation of the ECM during the onset of fibrotic diseases. However, the significance of PAI-1 in the developing intestinal fibrosis has not been fully understood. In the present study, we examined the actual expression of PAI-1 in fibrotic legion of intestinal inflammation and its correlation with the abnormal ECM deposition. Methods: Chronic intestinal inflammation was induced in BALB/c mice using 8 repeated intrarectal injections of 2,4,6-trinitrobenzene sulfonic acid (TNBS). TM5275, a PAI-1 inhibitor, was orally administered as a carboxymethyl cellulose suspension each day for 2 weeks after the sixth TNBS injection. Results: Using a publicly available dataset (accession number, GSE75214) and TNBS-treated mice, we observed increases in PAI-1 transcripts at active fibrotic lesions in both patients with CD and mice with chronic intestinal inflammation. Oral administration of TM5275 immediately after the onset of intestinal fibrosis upregulated MMP-9 (matrix metalloproteinase 9) and decreased collagen accumulation, resulting in attenuation of the fibrogenesis in TNBS-treated mice. Conclusions: PAI-1-mediated fibrinolytic system facilitates collagen degradation suppression. Hence, PAI-1 inhibitor could be applied as an anti-fibrotic drug in CD treatment. (Intest Res 2020;18:219-228)
N-페니글리신이 물과 카복실산 단량체의 HEMA 의 중합에 대한 효과
요지 이마이,윤숙진,김철위 서울대학교 치과대학 치과생체재료학교실 1995 치과생체재료학 논문집 Vol.3 No.1
목적 N-페닐글리신 (NPG)을 사용한 상아질 결합제의 결합기전을 위하여 HEMA의 중합에 물이나 카복실산 당량체의 효과를 연구한 것이다. 방법 물이나 4-MET 첨가로 NPG가 있을때 HEMA의 중합을 시차주사열량계 (DSC)로 평가하였다. 결과 물을 첨가할때 HEMA의 중합은 촉진하였고 카복실산 단량체로 4-MET를 첨가할때와 NPG에 대한 4-MET의 몰비율이 1.0~7.0일때도 중합은 촉진하였다. 의미 상아질면의 수분은 상아질 계면에서 NPG를 사용한 상아질 결합제의 중합을 촉진하여 결합강도를 개선할 수 있었다.
將軍鑛山의 鉛ㆍ亞鉛ㆍ銀 및 鐵 鑛床의 成因과 地質構造와의 關係
Hyun Koo Lee(李鉉具),Suck Jin Ko(高錫湊),Imai Naoya(今井直哉) 대한자원환경지질학회 1990 자원환경지질 Vol.23 No.2
The lead-zinc-silver-iron deposits from the Janggun mine are of hydrothermal-metasomatic origin, characterized by the marked hydrothermal alteration of the wallrocks, such as hydrothermal manganese enrichment of carbonate rocks, silicification, chloritization, sericitization, montmorillonitization and argillic alteration. The ore deposits have been emplaced within the Janggun Limestone of Cambro-Ordovician age at the immediate contacts with apophyses injected from the Chunyang Granite plutons of Late Jurrasic age. They have been structurally controlled by fractures in the carbonate rocks and the irregular intrusive contacts of granitic rocks, and are closely associated with hypogene manganese carbonate deposits. In the mine nine seperate orebodies are being mined. On the basis of the petrological study, hydrothermal alteration zone of this mine may be divided into the following four zones from wallrock to orebody. (Ⅰ) Primary calcite and dolomite zone→(Ⅱ) dolomitic limestone zone→(Ⅲ) dolomitic zone→(Ⅳ) rhodochrosite zone→orebody. There was not recongnized Mn and Fe elements in the primary calcite and dolomite zone. But, in the dolomitic limestone and dolomite zone, calcite and dolomite were subjected to weak hydrothermal manganese enrichment and the grade of the manganese enrichment increase oreward. By means of electron probe microanalysis, it was found that manganoan dolomite occured between primary dolomite grains, cross the cleavage of the primary dolomite and around the dolomite grains. Above these result supports that the Janggun manganese carbonate deposits are of hydrothermal metasomatic origin.
SiO MASERS AROUND WX PSC MAPPED WITH THE KVN AND VERA ARRAY (KaVA)
Yun, Youngjoo,Cho, Se-Hyung,Imai, Hiroshi,Kim, Jaeheon,Asaki, Yoshiharu,Chibueze, James O.,Choi, Yoon Kyung,Dodson, Richard,Kim, Dong-Jin,Kusuno, Kozue,Matsumoto, Naoko,Min, Cheulhong,Oyadomari, Miyak American Astronomical Society 2016 The Astrophysical journal Vol.822 No.1
<P>We present the first images of the v = 1 and v = 2 J = 1 -> 0 SiO maser lines taken with KaVA, i.e., the combined array of the Korean Very Long Baseline Interferometry (VLBI) Network and the VLBI Exploration of Radio Astrometry ( VERA), toward the OH/IR star WX Psc. The combination of long and short antenna baselines enabled us to detect a large number of maser spots, which exhibit a typical ring-like structure in both the v. =. 1 and v = 2 J = 1 -> 0 SiO masers as those that have been found in previous VLBI observational results of WX Psc. The relative alignment of the v = 1 and v = 2 SiO maser spots are precisely derived from astrometric analysis, due. to the absolute coordinates of the reference maser spot that were well determined in an independent astrometric observation with VERA. The superposition of the v = 1 and v = 2 maser spot maps shows a good spatial correlation between the v = 1 and v = 2 SiO maser features. Nevertheless, it is also shown that the v = 2 SiO maser spot is distributed in an inner region compared to the v - 1 SiO maser by about 0.5 mas on average. These results provide good support for the recent theoretical studies of the SiO maser pumping, in which both the collisional and the radiative pumping predict the strong spatial correlation and the small spatial discrepancy between the v = 1 and v = 2 SiO maser.</P>
이현구,고석주,나오야 이마이,Lee, Hyun Koo,Ko, Suck Jin,Naoya, Imai 대한자원환경지질학회 1990 자원환경지질 Vol.23 No.2
The lead-zinc-silver-iron deposits from the Janggun mine are of hydrothermal-metasomatic origin, characterized by the marked hydrothermal alteration of the wallrocks, such as hydrothermal manganese enrichment of carbonate rocks, silicification, chloritization, sericitization, montmorillonitization and argillic alteration. The ore deposits have been emplaced within the Janggun Limestone of Cambro-Ordovician age at the immediate contacts with apophyses injected from the Chunyang Granite plutons of Late Jurrasic age. They have been structurally controlled by fractures in the carbonate rocks and the irregular intrusive contacts of granitic rocks, and are closely associated with hypogene manganese carbonate deposits. In the mine nine seperate orebodies are being mined. On the basis of the petrological study, hydrothermal alteration zone of this mine may be divided into the following four zones from wallrock to orebody. (I) Primary calcite and dolomite zone${\rightarrow}$(II) dolomitic limestone zone${\rightarrow}$(III) dolomitic zone${\rightarrow}$(IV) rhodochrosite zone${\rightarrow}$ orebody. There was not recongnized Mn and Fe elements in the primary calcite and dolomite zone. But, in the dolomitic limestone and dolomite zone, calcite and dolomite were subjected to weak hydrothermal manganese enrichment and the grade of the manganese enrichment increase oreward. By means of electron probe microanalysis, it was found that manganoan dolomite occured between primary dolomite grains, cross the cleavage of the primary dolomite and around the dolomite grains. Above these result supports that the Janggun manganese carbonate deposits are of hydrothermal metasomatic origin.