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( Ji Yeoun Shin ),( Jeong Yeon Hong ),( Tae Heum Park ),( Soo Young Kim ),( Sung Yul Lee ),( Young Lip Park ),( Sang Hoon Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Atopic dermatitis is chronic inflammatory diseases associated with long-term use of topical and systemic treatment. Several articles have been described the use of balneotherapy as an adjuvant treatment for atopic dermatitis in many countries including Korea. Objectives: The goal of this study was to investigate the therapeutic efficacy and safety of balneotherapy in the adjuvant treatment of atopic dermatitis. Methods: Ten patients with concurrent atopic dermatitis were enrolled in this study and each patient served as their own control. Testing was conducted on the anterior cubital fossa of the arm. A priori binary randomization was completed to determine which arm would receive balneotherapy or tap water. They visited clinics three times per week for 2 weeks and had a forearm bath for 15 minutes. Assessment was performed at baseline, and after 1 and 2 weeks of treatment. Results: At the last visit, the balneotherapy group showed improvement in their local eczema area and severity index score and the value of transepidermal water loss. The physician’s global assessment, patient’s self global assessement and skin hydration was increased in the both groups. Conclusion: Our study suggests that balneotherapy is safe and considerable adjuvant therapy of atopic dermatitis, although more studies should be performed to demonstrate scientific basis.
피부 건강 박람회 방문자를 대상으로 한 피부 건강에 대한 인식과 행태에 관한 조사 연구
신지연 ( Ji Yeoun Shin ),강훈 ( Hoon Kang ),김문범 ( Moon Bum Kim ),김유찬 ( You Chan Kim ),박미연 ( Mi Youn Park ),박천욱 ( Chun Wook Park ),손상욱 ( Sang Wook Son ),유박린 ( Bark Lynn Lew ),이동윤 ( Dong Youn Lee ),이동훈 ( Don 대한피부과학회 2018 대한피부과학회지 Vol.56 No.8
Background: Healthy skin is an important determinant of the quality of life and physical and mental well-being. The demand for dermatological information is increasing not only in patients with skin diseases, but also in the general population with normal/healthy skin. However, public perception and behavior with regard to skin health among Koreans are not known. Objective: To examine public perception and behaviors with regard to skin health in Koreans visiting the Skin Health Expo 2017. Methods: A total of 597 participants completed a questionnaire that assessed demographics, status, and behavior for skin health and Expo satisfaction. Results: Respondents with higher stress levels and a history of skin diseases showed lower satisfaction with self-skin health. Most participants considered adequate sleep and water intake to be important factors associated with healthy skin. One-on-one consultation with dermatologists was the most satisfactory among participants at the Expo. Conclusion: Educational tools using mass media and informative activities such as the Expo planned by dermatologists and the government are necessary to spread awareness and provide proper information to improve skin health in thegeneral population and to emphasize the key role of dermatologists in skin disorders with a social burden. (Korean J Dermatol 2018;56(8):475∼484)
Modification of surgical procedure for “probable” limited dorsal myeloschisis
Lee, Ji Yeoun,Chong, Sangjoon,Choi, Young Hun,Phi, Ji Hoon,Cheon, Jung-Eun,Kim, Seung-Ki,Park, Sung Hye,Kim, In-One,Wang, Kyu-Chang American Association of Neurological Surgeons 2017 Journal of Neurosurgery: Pediatrics Vol.19 No.5
<B>OBJECTIVE</B><P>Since the entity limited dorsal myeloschisis (LDM) was proposed, numerous confusing clinical cases have been renamed according to the embryopathogenesis. However, clinical application of this label appears to require some clarification with regard to pathology. There have been cases in which all criteria for the diagnosis of LDM were met except for the presence of a neural component in the stalk, an entity the authors call “probable” LDM. The present study was performed to meticulously review these cases and suggest that a modified surgical strategy using limited laminectomy is sufficient to achieve the surgical goal of untethering.</P><B>METHODS</B><P>The authors retrospectively reviewed the imaging findings, operative notes, and pathology reports of spinal dysraphism patients with subcutaneous stalk lesions who had presented to their institution between 2010 and 2014.</P><B>RESULTS</B><P>Among 33 patients with LDM, 13 had the typical nonsaccular lesions with simple subcutaneous stalks connecting the skin opening to the spinal cord. Four cases had “true” LDM meeting all criteria for diagnosis, including pathological confirmation of CNS tissue by immunohistochemical staining with glial fibrillary acidic protein. There were also 9 cases in which all clinical, imaging, and surgical findings were compatible with LDM, but the “neural” component in the resected stalk was not confirmed. For all the cases, limited exposure of the stalk was done and satisfactory untethering was achieved.</P><B>CONCLUSIONS</B><P>One can speculate based on the initial error of embryogenesis that if the entire stalk were traced to the point of insertion on the cord, the neural component would be proven. However, this would require an extended level of laminectomy/laminotomy, which may be unnecessary, at least with regard to the completeness of untethering. Therefore, the authors propose that for some selected cases of LDM, a minimal extent of laminectomy may suffice for untethering, although it may be insufficient for diagnosing a true LDM.</P>
Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology.
Phi, Ji Hoon,Wang, Kyu-Chang,Park, Sung-Hye,Kim, Il Han,Kim, In-One,Park, Kyung Duk,Ahn, Hyo Seop,Lee, Ji Yeoun,Son, Young-Je,Kim, Seung-Ki M. Nijhoff ; Kluwer Academic Publishers 2012 Journal of neuro-oncology Vol.106 No.3
<P>Pediatric infratentorial ependymomas are difficult to cure. Despite the availability of advanced therapeutic modalities for brain tumors, total surgical resection remains the most important prognostic factor. Recently, histological grade emerged as an independent prognostic factor for intracranial ependymoma. We retrospectively reviewed the treatment outcome of 33 pediatric patients with infratentorial ependymoma. Progression-free survival (PFS) and overall survival (OS) rates were calculated and relevant prognostic factors were analyzed. Fourteen patients (42%) were under the age of 3 at diagnosis. Gross total resection was achieved in 16 patients (49%). Anaplastic histology was found in 13 patients (39%). Adjuvant therapies were delayed until progression in 12 patients (36%). Actuarial PFS rates were 64% in the first year and 29% in the fifth year. Actuarial OS rates were 91% in the first year and 71% in the fifth year. On univariate analysis, brainstem invasion (P = 0.047), anaplastic histology (P = 0.004), higher mitotic count (P = 0.001), and higher Ki-67 index (P = 0.004) were significantly related to a shorter PFS. Gross total resection (P = 0.029) and a greater age at diagnosis (P = 0.033) were significantly related to a longer PFS. On multivariate analysis, anaplastic histology alone was significantly related to a shorter PFS (P = 0.023). Gross total resection (P = 0.039) was significantly related to a longer overall survival (OS) on multivariate analysis. Anaplastic histology and gross total resection were the most important clinical factors affecting PFS and OS, respectively. Anaplastic histology, mitotic count, and Ki-67 index can be used as universal and easily available prognostic parameters in infratentorial ependymomas.</P>
Han, Ji Yeon,Choi, Jung Won,Wang, Kyu-Chang,Phi, Ji Hoon,Lee, Ji Yeoun,Chae, Jong-Hee,Park, Sung-Hye,Cheon, Jung-Eun,Kim, Seung-Ki KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11
<P>Radiotherapy is one of the standard treatments for medulloblastoma. However, therapeutic central nervous system irradiation in children may carry delayed side effects, such as radiation-induced tumor and vasculopathy. Here, we report the first case of coexisting meningioma and moyamoya syndrome, presenting 10 years after radiotherapy for medulloblastoma. A 13-year-old boy presented with an enhancing mass at the cerebral falx on magnetic resonance imaging (MRI) after surgery, radiotherapy (30.6 Gy craniospinal axis, 19.8 Gy posterior fossa) and chemotherapy against medulloblastoma 10 years ago, previously. The second tumor was meningioma. On postoperative day 5, he complained of right-sided motor weakness, motor dysphasia, dysarthria, and dysphagia. MRI revealed acute cerebral infarction in the left frontal lobe and both basal ganglia. MR and cerebral angiography confirmed underlying moyamoya syndrome. Four months after the meningioma surgery, the patient presented with headaches, dysarthria, and dizziness. Indirect bypass surgery was performed. He has been free from headaches since one month after the surgery. For patients who received radiotherapy for medulloblastoma at a young age, clinicians should consider the possibility of the coexistence of several complications. Careful follow up for development of secondary tumor and delayed vasculopathy is required.</P>
Primary meningeal rhabdomyosarcoma associated with chronic subdural effusion
Lee, Ji Yeoun,Kim, Bo Sung,Phi, Ji Hoon,Kang, Hyoung Jin,Park, Sung-Hye,Wang, Kyu-Chang,Kim, Il Han,Cho, Byung-Kyu,Kim, Seung-Ki Journal of Neurosurgery Publishing Group 2010 Journal of Neurosurgery: Pediatrics Vol.5 No.2
<P>Primary sarcomas of the CNS are rare and are sometimes associated with chronic subdural effusion (SDE). Approximately 10 patients with such presentations have been reported. The authors report the case of a 5-year-old boy with multiple subdural masses and SDE. An SDE had been diagnosed when the patient was 2 months old, and he received a subduroperitoneal shunt when he was 5 months old. Since then, he had been clinically stable and well for 5 years. When he presented with acute headache, nausea, and vomiting, a newly developed tumor was found. Near-total resection of the tumor was performed, and the mass was diagnosed as an embryonal-type rhabdomyosarcoma. The child was given radiation therapy and 13 cycles of chemotherapy and is still free of disease 13 months after surgery.</P>
Lee, Ji Yeoun,Moon, Youn Joo,Lee, Hae-Ock,Park, Ae-Kyung,Choi, Seung-Ah,Wang, Kyu-Chang,Han, Jung Woo,Joung, Je-Gun,Kang, Hyun Seung,Kim, Jeong Eun,Phi, Ji Hoon,Park, Woong-Yang,Kim, Seung-Ki American Heart Association 2015 Arteriosclerosis, thrombosis, and vascular biology Vol.35 No.7
<P>Objective-- Moyamoya disease (MMD) is a common cause of childhood stroke, in which the abnormal function of the endothelial colony-forming cell (ECFC) plays a key role in the pathogenesis of the disease. This study was designed to identify genes involved in MMD pathogenesis using gene expression profiling and to understand the defective function of MMD ECFCs. Approach and Results-- We compared gene expression profiles of ECFCs isolated from patients with MMD and normal controls. Among the differentially expressed genes, we selected a gene with the most downregulated expression, retinaldehyde dehydrogenase 2 (RALDH2). The activity of RALDH2 in MMD ECFCs was assessed by in vitro tube formation assay and in vivo Matrigel plug assay in the presence of all-trans retinoic acid. The transcriptional control of RALDH2 was tested using ChIP assays on acetyl-histone H3. In the results, MMD ECFCs inefficiently formed capillary tubes in vitro and capillaries in vivo, a defect restored by all-trans retinoic acid treatment. Knockdown of RALDH2 mRNA in normal ECFCs also induced decreased activity of capillary formation in vitro. The decreased level of RALDH2 mRNA in MMD ECFCs was attributed to defective acetyl-histone H3 binding to the promoter region. Conclusions-- From these results, we conclude that the expression of RALDH2 was epigenetically suppressed in ECFCs from patients with MMD, which may play a key role in their functional impairment.</P>
( Sowon Park ),( Ben Kang ),( Seung Kim ),( Sujin Choi ),( Hyo Rim Suh ),( Eun Sil Kim ),( Ji Hyung Park ),( Mi Jin Kim ),( Yon Ho Choe ),( Yeoun Joo Lee ),( Jae Hong Park ),( Eell Ryoo ),( Hong Koh ) 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6
Background/Aims: We aimed to compare the differences in pediatric Crohn’s disease (CD) and ulcerative colitis (UC) at diagnosis in Korea. Methods: This was a multicenter, registry-based, inception cohort study conducted at five centers in Korea between 2013 and 2017. Baseline demographics, clinical characteristics, and results from laboratory, endoscopic, radiologic examinations were compared between pediatric CD and UC patients who were <19 years old at diagnosis. Results: A total 307 patients were included (227 CD [73.9%] and 80 UC [26.1%]). The male to female ratio was 2.49:1 for CD, and 1.49:1 for UC (p=0.019). Median age at diagnosis was 14.4 years (interquartile range, 12.4 to 16.2) for CD, and 14.4 years (interquartile range, 11.7 to 16.5) for UC (p=0.962). Hematochezia was the only dominant symptom in UC patients compared to CD patients (86.2% vs 30.8%, p<0.001). White blood cell counts, platelet counts, erythrocyte sedimentation rate, and C-reactive protein levels were significantly higher, and serum albumin level was significantly lower in CD patients than in UC patient. Anti-Saccharomyces cerevisiae antibody was positive in 44.5% and 16.2% of CD and UC patients, respectively (p<0.001), and antineutrophil cytoplasmic antibody was positive in 15.0% and 58.8% of CD and UC patients, respectively (p<0.001). Terminal ileal involvement was prominent in CD, while rectal involvement was more prominent in UC. Small bowel involvement and perianal perforating diseases were also more prominent in CD. Conclusions: This is the first a multicenter study in Korea to compare the differences between pediatric CD and UC at diagnosis in Korea. A large-scale, national study is expected to better clarify these findings in the future. (Gut Liver 2022;16:921-929)