영덕 달산 지역 화산층서와 용암의 공급지

황상구,함희수,김지영,정해오 안동대학교 기초과학연구소 1999 基礎科學 硏究論文集 Vol.10 No.1

We traced the flow direction of Ipbong Andesite and dacite in Dalsan area, Yeongdeok. Elongate vesicles and lathlike plagioclase phenocysts are aligned in the outcrops or under microscope. The lineations from their alignment are excellently indicating the flow direction of lavas. The flow directions, which were measured from the lineations in the Ipbong Andesite, are NNW-SSE in the eastern part and NNE-SSW in the southwestern part. The flow lineations show a fanlike movement pattern from the mid-northern part that the diorite is distributed. The diorite area is prabably a potential source area of the andesite

바터팽대부 선암의 β-catenin 표현

현연화,구지혜,이강,박선미,성노현 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

Purpose : Carcinomas of the ampulla of Vater have either intestinal or pancreatobiliary type differentiation. The molecular pathogenesis of both histologic types of ampullary carcinoma are not yet well characterized. The role of β-catenin pathway is important in colorectal carcinogenesis and β-catenin protein expression is dysregulated in the early stage of the adenoma-carcinoma sequence. The aim of this study is to investigate the differences between dysregulated β-catenin expression in the carcinogenesis of two histologic types of carcinoma of the ampulla of Vater. Materials and Methods : We examined 24 cases of resected carcinoma of the ampulla of Vater. Serial sections of all carcinoma specimens were stained with antibodies to cytokeratins (CK7, CK20) and β-catenin. Normal expression of β-catenin was defined as exclusive membranous staining. Dysregulated expression of β-catenin was defined as cytoplasmic staining in more than 50% of tumor cells and/or nuclear staining. Results : Ten carcinomas (42%) were immunohistochemically intestinal type (CK7-, CK20+) and eleven carcinomas (46%) were pancreatobiliary type (CK+, CK20-). Three carcinomas were immunohistochmically other types (CK7+, CK20+ or CK7-, CK20-). Abnormal β-catenin was accumulated in nine cases (90%) of intestinal type. Among them, nuclear staining was noted in two cases with moderately and poorly differentiated histology respectively. In pancreatobiliary type, only one case (9%) with poorly differentiated histology showed abnormal β-catenin expression in tumor nuclei. Conclusion : Dysregulation of β-catenin expression may play critical role in the carcinogenesis of intestinal type, but not of pancreatobiliary type. Abnormal accumulation of β-catenin in tumor nuclei may be related to poorly differentiated histology in both types of ampullary carcinoma. 연구 목적: 바터팽대부에서 발생하는 선암의 대부분은 조직학적으로 장형과 췌담형으로 구성된다. 두 병변의 발암기전은 뚜렷하게 밝혀진 바는 없으나, 췌담형 선암은 췌담도 선암의 발암기전과 유사하고, 장형 선암은 장 선암의 발암기전과 유사하다고 추측한다. 대부분의 장 선암에서는 암 발생 초기에 세포 안에 β-catenin의 축적이 발생하며, 축적된 β-catenin이 전암 세포 또는 암 세포의 증식을 유발하는 중요한 역할을 한다. 그러나 대부분의 췌담도 선암의 발생 과정에서는 β-catenin 축적에 의한 세포 증식은 중요한 역할을 하지 않는다. 바터팽대부에서 발생하는 장형 선암과 췌담형 선암의 발암 과정의 유사점 또는 차이점을 규명하기 위하여, 장 선암의 발암 과정에서는 중요한 역할을 하지만 췌담도의 선암의 발암 과정에는 역할이 중요하지 않은 β-catenin의 축적으 면역조직화학 방법으로 비교하였다. 재료 및 방법: 충북대학교병원에서 외과적 수술로 절제한 바터팽대부에서 발생한 선암 24 예의 조직 slide를 현미경으로 관찰하고, 각 증례의 병변을 대표하는 조직의 paraffin 포매 block 한 개를 선택하여 박편을 제작하였다. 장형 선암과 췌담형 선암을 면역조직화학 방법으로 구분하기 위하여 각 박편에 통상적인 avidin-biotin immunoperoxidase 방법으로 cytokeratin 7과 cytokeratin 20 면역 염색을 하였으며, 발암기전의 차리를 알기 위하여 β-catenin 면역 염색을 하였다. β-catenin의 축적은 종양 세포의 50% 이상에서 세포질에 뚜렷하게 염색된 경우와 종양 세포의 핵에 염색된 경우를 양성으로 하였다. 결과: 10 예는 cytokeratin 7에 음성. cytokeratin 20에 양성이어서 장형 선암으로 분류하였다. 11 예는 cytokeratin 7에 양성. cytokeratin 20에 음성이어서 췌담형 선암으로 분류하였다. 3 예는 cytokeratin 7과 cytokeratin 20에 모두 양성 또는 모두 음성이엇 연구에서 제외하였다. 장형 선암은 9 예(90%)에서 β-catenin의 축적이 나타났다. 종양 세포 핵의 β-catenin 축적은 중등도 분화 암 3 예 중에서 1 예. 저등도 분화 암 1 예 중 1 예에서 관찰되었다. 고등도 분화 암에 동반된 선종 2 예에서도 종양 세포의 세포질에 β-catenin의 축적이 관찰되었다. 췌담형 선암은 11 예 중에서 1 예(9%)에서 β-catenin의 축적이 나타났으며 나머지 10 예는 세포막에만 염색되었다. β-catenin의 축적은 저등도 분화 암 1 예 중에서 1 예에 나타났으며 세포 핵에서 β-catenin의 축적이 나타났다. 결론: 바터팽대부에서 발생하는 장형 선종과 선암의 발암 과정에는 β-catenin의 축적이 중요한 역할을 하며, 장형 선암의 발암 과정은 장의 선종-선암 과정과 유사함을 시사하였다. 바터팽대부에서 발생하는 대부분의 췌담형 선암 세포에서는 β-catenin의 축적이 발생하지 않았으므로 췌담형 선암의 발암기전은 장형 선암의 발암기전과 다름을 시사하였다. 그러나 β-catenin의 종양 세포 핵 축적은 바터팽대부에서 발생하는 장형과 췌담형 선암의 악성화와 관계가 있었다.

젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

Transfer of L1 writing proficiency among EFL students: Testing the threshold hypothesis with Korean 9th grade EFL learners

Ji-Hae Koo 한국언어연구학회 2012 언어학연구 Vol.17 No.2

A New Mid-Season Peach Cultivar, ‘Misshong’

Ji Hae Jun,Kyeong Ho Chung,Ik Koo Yun,Jung Hyun Kwon,Sung Ji Hae Jun,Sung Jong Kim,Yong Bum Kwack,Kyung Bok Ma,Jung Bae Kim 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.5

The Effects of Korean Medicine Treatment for Meniscus Tears: A Retrospective Chart Review

Park Ji-won,Jeong Myung-In,Jeong Wu-Jin,Hong Hae-Won,Koo Ji-eun,Bae Jun-Hyo,Kim Su-jin,Bae Ji-eun 대한침구의학회 2022 대한침구의학회지 Vol.39 No.3

Changes in symptoms and dysfunction related to meniscus tears following the use of Korean medicine for ≥ 4 days were studied. The medical charts of 53 cases of diagnosed meniscus tears (magnetic resonance imaging) with an admission Numeric Rating Scale (NRS) score ≥ 4, between 2017 and 2022 were retrospectively reviewed. Treatments included acupuncture, pharmacopuncture, herbal treatment, Chuna therapy, and physiotherapy. The NRS, Western Ontario and McMaster Universities Osteoarthritis Index, and European Quality of Life 5 Dimensions were performed at admission and discharge. There were 42 females and 11 males in this study. Patients were more likely to be in their 60s (38.18%), have an unknown etiology (81.13%), and have complex tears (50.94%). After receiving a combination of alternative Korean medicine during hospitalization, the mean NRS score improved from 6.82 ± 1.19 to 3.66 ± 1.83 (p < 0.001), the Western Ontario and McMaster Universities Osteoarthritis Index score improved from 46.47 ± 20.99 to 37.98 ± 19.23 (p < 0.001), and the mean European Quality of Life Five Dimensions score improved from 0.61 ± 0.18 to 0.68 ± 0.14 (p < 0.001) after treatment. These results suggest that Korean medicine treatment of meniscus tears alleviated pain and improved physical function.

Analysis of Vitamin D3 Up-regulated Protein 1(VDUP1) knockout mouse by broad-based phenotyping

Ji-Seon Park,HaeRim Kim,Ki-Sun Kim,Eun-Kyoung Kim,Young-Won Seo,Won-Kee Yoon,Taek-Chang Lee,Hae-Jin Lee,Sang-Woon Kim,Jong-Soon Kang,Hyun-Ju Lee,Chul-Ho Lee,Jong-Koo Kang,Ki-Hoan Nam,Hyoung-Chin Kim 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.8

The Hydraulic System of Respiratory Organs Simulator

Hae Jin Lee,Hyuk Jin Lee,Young Nam Gang,Ji Na Kim,Ja Choon Koo 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.춘계 No.-

A New Plum Cultivar ‘Summer Fantasia’

Ji Hae Jun,Eun Young Nam,Kyeong Ho Chung,Seok Kyu Yun,Jung Hyun Kwon,Ik Koo Yoon,Yong Bum Kwack,Sung Jong Kim 한국원예학회 2013 한국원예학회 학술발표요지 Vol.2013 No.10

Articles : Optimization of Fractionation Operation in the Benzene-Toluene-Xylene Plant

( Hae Dong Chung ),( Ji Soo Yi ),( Yeong Koo Yeo ),( Kun Soo Chang ),( Young Chul Gil ),( Hong Young Choi ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.5

A steady-state optimization for the fractionation unit of an industrial benzene-toluene-xylene (BTX) plant was developed. Because the fractionation unit of the BTX plant has narrow ranges of boiling point and doesn`t have any sidecut and side reboiler, we employed the boiling point estimation method in the modeling and simulation of the unit. The well-known Soave-Redlich-Kwong state equation was employed to compute required thermodynamic properties. The results of simulations showed very good agreement with the actual operation data. The objective of the optimization was to maximize profit of fractionation unit. The successive quadratic programming algorithm was utilized and objective functions for each fractionation column were set up based on utility and operation costs and selling prices of products. The graphical user interface of the optimization system was developed to provide convenience and flexibility in actual applications.