XPC 939A>C and 499C>T Polymorphisms and Skin Cancer Risk: a Meta-analysis

Ji, Geng,Lin, Yuan,Cao, Song-Yu,Li, Luo-Zhu,Chen, Xin-Long,Sun, Bu-Mei,Chen, Chuan-Jun,Ma, Hong-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.

Combined Application Effects of Arbuscular Mycorrhizal Fungi and Biochar on the Rhizosphere Fungal Community of Allium fistulosum L.

Ji Chunxiang,Li Yingyue,Xiao Qingchen,Li Zishan,Wang Boyan,Geng Xiaowan,Lin Keqing,Zhang Qing,Jin Yuan,Zhai Yuqian,Li Xiaoyu,Chen Jin 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.8

Arbuscular mycorrhizal fungi (AMF) are widespread soil endophytic fungi, forming mutualistic relationships with the vast majority of land plants. Biochar (BC) has been reported to improve soil fertility and promote plant growth. However, limited studies are available concerning the combined effects of AMF and BC on soil community structure and plant growth. In this work, a pot experiment was designed to investigate the effects of AMF and BC on the rhizosphere microbial community of Allium fistulosum L. Using Illumina high-throughput sequencing, we showed that inoculation of AMF and BC had a significant impact on soil microbial community composition, diversity, and versatility. Increases were observed in both plant growth (the plant height by 8.6%, shoot fresh weight by 12.1%) and root morphological traits (average diameter by 20.5%). The phylogenetic tree also showed differences in the fungal community composition in A. fistulosum. In addition, Linear discriminant analysis (LDA) effect size (LEfSe) analysis revealed that 16 biomarkers were detected in the control (CK) and AMF treatment, while only 3 were detected in the AMF + BC treatment. Molecular ecological network analysis showed that the AMF + BC treatment group had a more complex network of fungal communities, as evidenced by higher average connectivity. The functional composition spectrum showed significant differences in the functional distribution of soil microbial communities among different fungal genera. The structural equation model (SEM) confirmed that AMF could improve the microbial multifunctionality by regulating the rhizosphere fungal diversity and soil properties. Our findings provide new information on the effects of AMF and biochar on plants and soil microbial communities.

A Simple Approach for Preparing Transparent Conductive Graphene Films Using the Controlled Chemical Reduction of Exfoliated Graphene Oxide in an Aqueous Suspension

Geng, Jianxin,Liu, Leijing,Yang, Seung Bo,Youn, Sang-Cheon,Kim, Dae Woo,Lee, Ji-Sun,Choi, Jong-Kil,Jung, Hee-Tae American Chemical Society 2010 The Journal of Physical Chemistry Part C Vol.114 No.34

<P>We report a simple method for preparing transparent conductive graphene films using a chemically converted graphene (CCG) suspension that was obtained via controlled chemical reduction of exfoliated graphene oxide (GO) in the absence of dispersants. Upon thermal annealing of the CCG films, the films displayed a sheet resistance on the order of 10<SUP>3</SUP> Ω·◻<SUP>−1</SUP> at 80% transparency (550 nm), with a bulk conductivity on the order of 10<SUP>2</SUP> S·cm<SUP>−1</SUP>. FT-IR, UV−visible, and X-ray photoelectron spectroscopy results showed that the combination of the controlled reduction of GO in suspension and thermal annealing of the CCG films efficiently restored the sp<SUP>2</SUP> carbon networks of the graphene sheets, facilitating charge carrier transport in the individual CCG sheets. Furthermore, grazing-incidence X-ray diffraction results showed that the thermal annealing of the CCG films reduced the interlayer distance between the CCG sheets to a distance comparable to that in bulk graphite, facilitating charge carrier transport across the CCG sheets. Polymer solar cell devices composed of the CCG films as transparent electrodes showed power conversion efficiencies, η, of 1.01 ± 0.05%, which corresponded to half the value (2.04 ± 0.1%) of the reference devices, in which indium tin oxide-covered glass was used for the transparent electrode.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2010/jpccck.2010.114.issue-34/jp105029m/production/images/medium/jp-2010-05029m_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp105029m'>ACS Electronic Supporting Info</A></P>

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Zhao, Ji-An,Peng, Li,Geng, Cui-Zhi,Liu, Yue-Ping,Wang, Xu,Yang, Hui-Chai,Wang, Shi-Jie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model. One hundred and twenty male SD rats used in this study were divided into six groups. Those receiving DEN with curcumin (CUR) or HZC were studied compared with the DEN-alone group. The study demonstrated that DEN induced severe histological and immunohistochemical changes in liver tissues, significantly increasing the levels of liver marker enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), ${\gamma}$-glutamyltransferase (GGT) and total bilirubin level (TBL)). The hepatocarcinoma incidences were 100.0%, 36.7% and 20.0% in the DEN-alone, DEN-CUR and DEN-HZC groups, respectively. Although macroscopic and microscopic features suggested that both CUR and HZC were effective in inhibiting DEN-induced hepatocarcinogenesis, HZC was exerted a stronger influence. Immunohistochemical analysis with PCNA demonstrated significantly differences among the groups (all P < 0.05). Taken together, the results suggested application of CUR and HZC could prevent the occurrence of carcinogenesis and HZC may be a more potent compound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR.

중국 쑤저우 평강로 도시역사문화거리 보존 및 재생사업 평가연구

경리(Geng Li),윤지영(Ji-Young Yoon) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.5

쑤저우 평강로 역사문화거리를 분석 대상으로 도시역사거리의 발전과 보호에 대해 알아보았다. 다음과 같은 방식을 통해 도시역사거리에서 문화거리의 발전, 재생방법과 현황에 대해 전면적인 조사를 진행하였다. 우선 역사문화거리의 개념과 특성을 이해하고, 문헌조사를 통해 역사문화거리의 보존과 재생특성을 물리적 요소와 비물리적 요소로 정리했다. 또한, 한국의 인사동, 삼청동, 중국 베이징의 난뤄구샹, 항저우의 남송어가 등 4개 역사문화거리의 통합디자인교류시스템을 분석하고 연구했다. 기초 연구와 분석을 거쳐 비물리적 요소에서 문화성, 경제성, 사회성에 포함되는 평가 기준을 마련하고 물리적 요소를 공간 구조, 도로 맥락, 건물 보존으로 나누어 분석틀을 정리했다. 평강로에서 비물리적 요소와 물리적 요소의 복합적인 발전 관점을 제시하여 역사문화거리의 보존과 재생에 평가 모델을 제공할 수 있다는 점에서 의의가 있다. 또한 현장 조사를 결합해 방문객을 위한 프로그램 및 서명 시스템의 정비와 개발, 역사문화 네트워크 플랫폼의 지속적인 개발 등 방면의 미흡한 부분에 대해 최적화와 구체적인 연구를 진행할 필요가 있으며, 이를 통해 같은 유형의 다른 역사문화거리에 참고할 만한 기초 자료를 제공하여야 한다. This study analyses the historical and cultural streets at Pinggang Road in the city of Suzhou, by understanding the development and conservation of the area, and uses the following ways to investigate its development, re-organization, and current state. This paper comprehensively compares, collates and investigates 4 different historical and cultural areas in Insadong and Samcheong-dong in South Korea, and South Luogu Lane in China. From initial research and analysis, this paper gathers the cultural, economic, and societal perspectives as non-physical measures, and spatial structure, road structure, and building maintenance as physical factor framework. It is significant in that it can provide an evaluation model for the preservation and regeneration of historical and cultural streets by presenting the viewpoint of complex development of non-physical and physical elements in Pyeonggang-ro. In addition, it is necessary to conduct optimization and specific research on insufficient areas, such as maintenance and development of programs and signature systems for visitors, and continuous development of historical and cultural network platforms by combining on-site surveys. Basic data should be provided for reference on the street.

Improvement of Biomineralization of Sporosarcina pasteurii as Biocementing Material for Concrete Repair by Atmospheric and Room Temperature Plasma Mutagenesis and Response Surface Methodology

( Pei-pei Han ),( Wen-ji Geng ),( Meng-nan Li ),( Shi-ru Jia ),( Ji-long Yin ),( Run-ze Xue ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.9

Microbially induced calcium carbonate precipitation (MICP) has recently become an intelligent and environmentally friendly method for repairing cracks in concrete. To improve on this ability of microbial materials concrete repair, we applied random mutagenesis and optimization of mineralization conditions to improve the quantity and crystal form of microbially precipitated calcium carbonate. Sporosarcina pasteurii ATCC 11859 was used as the starting strain to obtain the mutant with high urease activity by atmospheric and room temperature plasma (ARTP) mutagenesis. Next, we investigated the optimal biomineralization conditions and precipitation crystal form using Plackett-Burman experimental design and response surface methodology (RSM). Biomineralization with 0.73 mol/l calcium chloride, 45 g/l urea, reaction temperature of 45°C, and reaction time of 22 h, significantly increased the amount of precipitated calcium carbonate, which was deposited in the form of calcite crystals. Finally, the repair of concrete using the optimized biomineralization process was evaluated. A comparison of water absorption and adhesion of concrete specimens before and after repairs showed that concrete cracks and surface defects could be efficiently repaired. This study provides a new method to engineer biocementing material for concrete repair.

Non-monotonic responses of Atlantic Meridional Overturning Circulation to Antarctic meltwater forcing

Yechul Shin,Xin Geng,Kyung-Min Noh,Ji-Hoon Oh,Jong-Seong Kug 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.11

Molecular Level Study of Graphene Networks Functionalized with Phenylenediamine Monomers for Supercapacitor Electrodes

Song, Bo,Choi, Ji Il,Zhu, Yuntong,Geng, Zhishuai,Zhang, Le,Lin, Ziyin,Tuan, Chia-chi,Moon, Kyoung-sik,Wong, Ching-ping American Chemical Society 2016 Chemistry of materials Vol.28 No.24

<P>Three phenylenediamine (PD) monomers, o-phenylenediamine (OPD), m-phenylenediamine (MPD), and p-phenylenediamine (PPD), were used to prepare the functionalized graphene (PD/rGO) networks. The results obtained from a series of chemical, thermal, and rheological analyses elucidated the mechanism of the covalent bonding and the existence of cross-linked graphene networks. The measured XRD patterns and molecular dynamic calculations discovered that those PPD and MPD molecules could enlarge graphene interlayer spacing to 1.41 and 1.30 nm, respectively, while OPD molecules were disorderly bonded or nonbonded to the basal planes of graphene layers, resulting in small and variable inter layer distances. The loadings of PD monomers were optimized to achieve superior supercapacitor performance. Electrochemical study showed that PPD/rGO exhibited the largest specific capacitance of 422 F/g with excellent cycling stability and low charge transfer resistance. The large variations in the capacitance values among PD/rGO networks with different PD monomers were explained by the difference in the graphene nanostructures, reversible redox transitions, and charge transfer characteristics. Particularly, density function theory calculations were adopted to compare electronic properties of the PD/rGO composites, including formation energy, electron density distribution, HOMO energy levels, and electron density of states near the Fermi level.</P>

A pairing-free key-insulated certificate-based signature scheme with provable security

( Hu Xiong ),( Shikun Wu ),( Ji Geng ),( Emmanuel Ahene ),( Songyang Wu ),( Zhiguang Qin ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.3

Certificate-based signature (CBS) combines the advantages of both public key-based signature and identity-based signature, while saving from the disadvantages of drawbacks in both PKS and IBS. The insecure deployment of CBS under the hostile circumstances usually causes the exposure of signing key to be inescapable. To resist the threat of key leakage, we present a pairing-free key insulated CBS scheme by incorporating the idea of key insulated mechanism and CBS. Our scheme eliminates the costly pairing operations and as a matter of fact outperforms the existing key insulated CBS schemes. It is more suitable for low-power devices. Furthermore, the unforgeability of our scheme has been formally proven to rest on the discrete logarithm assumption in the random oracle model.

Non-monotonic responses of Atlantic Meridional Overturning Circulation to Antarctic meltwater forcing

Yechul Shin,Xin Geng,Kyung-Min Noh,Ji-Hoon Oh,Jong-Seong Kug 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.10