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( Jeong Hwee Choi ),( In Jung Kang ),( Ki Heon Jeong ),( Min Kyung Shin ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Successful delivery of photosensitizer into skin is important for effective photodynamic therapy (PDT). The major rate-limiting barrier for percutaneous drug absorption is the stratum corneum. Several methods have been developed to overcome this. Objectives: To analyze and compare the effectiveness of ablative fractional laser (FXL) pretreatment and/or sonophoresis for enhancing the penetration of 5-aminolevulinic acid (ALA) into human skin in vivo. Methods: 24 identical 1×1 cm2 treatment areas were mapped on the backs of 10 healthy male subjects. Each area received laser pretreatment and/or sonophoresis with different energy settings and ALA incubation times. We used 10,600 nm CO2 FXL and/or sonophoresis, and then measured porphyrin fluorescences. Results: Ablative CO2 FXL pretreatment group showed higher fluorescence intensities than non-treatment group. Sonophoresis group showed similar effect. Incubation times were positively correlated with increments of ALA penetration. However, increasing pulse energy or combining with sonophoresis did not show additional positive effects on ALA penetration. Conclusion: Ablative CO2 FXL pretreatment and sonophoresis effectively facilitated ALA penetration in human skin in vivo. Ablative CO2 FXL alone, not together with sonophoresis, and pulse energy of 10 mJ with more than 60 minutes of ALA incubation time showed the best results.
( Jeong Hwee Choi ),( Min Jae Gwak ),( In Jung Kang ),( Hee Kyeong Lim ),( Ki Heon Jeong ),( Ji Youn Sung ),( Nack In Kim ),( Min Kyung Shin ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Recent researches have investigated the use of autofluorescence (AF) to distinguish between normal and cancerous tissues according to different fluorescence characteristics. Objectives: The aim of this study was to analyse if AF can help differentiate cancerous lesions from other benign dermatitis. Methods: Paraffin-embedded tissue samples were obtained from patients who were histopathologically diagnosed with SCC, psoriasis, chronic dermatitis (lichen simplex chronicus, prurigo nodularis), or acute dermatitis (atopic dermatitis). AF intensities were measured from four layers of the epidermis: the corneal layer, granular layer, spinous layer, and basal layer, as well as two layers of the dermis: papillary dermis and reticular dermis. Results: AF was highest in psoriasis samples compared to all other groups in all layers. Higher AF values were seen in the SCC group as compared to all skin layers of the acute and chronic dermatitis groups; this finding was especially true in the corneal layer, papillary dermis, and reticular dermis. Conclusion: This ex vivo AF study may provide the basic data for future in vivo AF studies that will investigate the use of this non-invasive diagnostic tool.
Dermoscopy로 감별한 피부섬유종 양상으로 나타난 피부유육종증
최정휘 ( Jeong Hwee Choi ),이무형 ( Mu Hyoung Lee ),신민경 ( Min Kyung Shin ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.8
Sarcoidosis is a multisystem granulomatous disease of unknown cause. The lung is the most commonly affected organ, but the skin is frequently involved. Specific sardoidal lesions are most often found on the head and neck area. The most common specific presentation is multiple papular lesions. The present case shows solitary cutaneous sarcoidosis resembling dermatofibroma, located on the thigh. Dermoscopy can help in the differential diagnosis of cutaneous sarcoidosis. Dermoscopic findings are orange globular-like structures and linear vessels, and areas of scar- like depigmentation. Histopathologic findings show non-caseating granulomas with sparse inflammatory cells. We report a case of cutaneous sarcoidosis resembling dermatofibroma, which was diagnosed using dermoscopy. (Korean J Dermatol 2013;51(8):643∼645)
아토바스타틴의 새로운 약물 적응증 탐색을 위한 비정형 데이터 분석
정휘수 ( Hwee-soo Jeong ),강길원 ( Gil-won Kang ),최웅 ( Woong Choi ),박종혁 ( Jong-hyock Park ),신광수 ( Kwang-soo Shin ),서영성 ( Young-sung Suh ) 한국보건정보통계학회 2018 보건정보통계학회지 Vol.43 No.4
Objectives: In recent years, there has been an increased need for a way to extract desired information from multiple medical literatures at once. This study was conducted to confirm the usefulness of unstructured data analysis using previously published medical literatures to search for new indications. Methods: The new indications were searched through text mining, network analysis, and topic modeling analysis using 5,057 articles of atorvastatin, a treatment for hyperlipidemia, from 1990 to 2017. Results: The extracted keywords was 273. In the frequency of text mining and network analysis, the existing indications of atorvastatin were extracted in top level. The novel indications by Term Frequency-Inverse Document Frequency (TF-IDF) were atrial fibrillation, heart failure, breast cancer, rheumatoid arthritis, combined hyperlipidemia, arrhythmias, multiple sclerosis, non-alcoholic fatty liver disease, contrast-induced acute kidney injury and prostate cancer. Conclusions: Unstructured data analysis for discovering new indications from massive medical literature is expected to be used in drug repositioning industries.
입원환자 영양지원에 대한 일개대학병원 의료진의 태도 및 관련 요인
정휘수 ( Hwee Soo Jeong ),등건훈 ( Chen Hsuen Teong ),최유정 ( You Jung Choi ),김우정 ( Woo Jeng Kim ),이아란 ( Ah Ran Lee ) 한국정맥경장영양학회 2014 한국정맥경장영양학회지 Vol.6 No.1
Purpose: Knowledge of nutritional support and attitudes of medical staff both affect patient care. We identified attitudes regarding nutritional support among medical staff as well as changes in attitudes when a nutritional support team is present. Methods: Data were collected from 172 medical staff members who served at a university hospital located in Gyeongju by self-administered questionnaire from June 12∼August 30, 2013. The questionnaire inquired about importance of nutritional support, self-confidence about nutritional support, consideration of nutritional support for patient care, consideration of nutritional support when a nutritional support team is present, and nutritional knowledge training during the past year. Results: A total of 169 subjects (98.3%) thought that nutritional support is important for patient care. Only 19 subjects (11.0%) were highly self-confident about nutritional support. In total, 147 subjects (85.5%) considered nutritional support for some or all patients, whereas 169 (98.3%) considered nutritional support for patient care when a nutritional support team is present. Thirty-eight subjects (22.1%) received nutritional knowledge training during the past year. High self-confidence for nutritional support was related to nutritional knowledge training and service part. Positive changes regarding nutritional support when a nutritional support team is present were associated with nutritional knowledge training and high self-confidence for nutritional support. Conclusion: No differences in nutritional support attitudes for patient care were observed among the medical staff. Nutritional knowledge training and service part affected self-confidence of nutritional support and induced positive changes in attitudes for nutritional support.
( In Jung Kang ),( Jeong Hwee Choi ),( Min Jae Gwak ),( Hee Kyeong Lim ),( Nack In Kim ),( Min Kyung Shin ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: There are various reports in the use of ICG in dermatologic field. Objectives: Using ICG as the test drug, we measured immediate drug absorption assisted by ablative fractional radiofrequency (RF) combined sonophoresis ex vivo. Methods: Two male domestic Yorkshire swine were used in this study and skin tissue without subcutaneous fat was obtained from the flank area. Fractional ablative RF was performed with laser power of 50 W and 100 W. A 0.2% IGC cream was applied in the amount of 0.3g per 3x3 cm2 skin area which were covered and occluded with aluminum foil to avoid light exposure. After ICG application, sonophoresis was performed with power of 50 Hz for 30 seconds. Average fluorescence index (FI) was measured immediately after treatment. Results: The fluorescence induced by ICG was significantly higher on fractional RF and sonophoresis pretreated skin surface compared to the untreated area (P<0.0001). Higher treatment energy tends to enhance fluorescence more than lower energy. However, there was no statistical significance between the two different energy groups. Conclusion: In this study, we demonstrated that fractional RF combined sonophoresis pretreatment can facilitate skin penetration of ICG. This pretreatment process can shorten the incubation period of ICG and maximize the effect of treatment.
( Dong Hye Suh ),( Jeong Hwee Choi ),( Sang Jun Lee ),( Ki Heon Jeong ),( Kye Yong Song ),( Min Kyung Shin ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: High-intensity focused ultrasound (HIFU) and radiofrequency (RF) are used for non-invasive skin tightening. Neocollagenesis and neoelastogenesis have been reported to have a mechanism of controlled thermal injury. Objectives: To compare neocollagenesis and neoelastogenesis in each layer of the dermis after each session of HIFU and monopolar RF. Methods: We analyzed the area fraction of collagen and elastic fibers using the Masson’s trichrome and Victoria blue special stains, respectively, before and after 2 months of treatments. Histometric analyses were performed in each layer of the dermis, including the papillary dermis, and upper, mid,and deep reticular dermis. Results: Monopolar RF led to neocollagenesis in the papillary dermis, and upper, mid, and deep reticular dermis, and neoelastogenesis in the papillary dermis, and upper and midreticular dermis. HIFU led to neocollagenesis in the mid and deep reticular dermis and neoelastogenesis in the deep reticular dermis. Among these treatment methods, HIFU showed the highest level of neocollagenesis and neoelastogenesis in the deep reticular dermis. Conclusion: HIFU affects deep tissues and impacts focal regions. Monopolar RF also affects deep tissues, but impacts diffuse regions. We believe this data provide further insight into effective skin tightening.
( In Jung Kang ),( Jeong Hwee Choi ),( Min Jae Gwak ),( Min Kyung Shin ),( Nack In Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues. Recent studies showed that AQP3-mediated transport of water and glycerol is involved in keratinocyte migration Objectives: To evaluate the AQP3 signaling module in skin diseases, we determined their levels in psoriasis, squamous cell carcinoma(SCC) and atopic dermatitis as compared to normal epidermis. Methods: Skin biopsies with the appropriate diagnoses (each three of the normal control, psoriasis, SCC, and atopic dermatitis samples) were obtained from the pathology archives and examined by immunohistochemistry using antibodies recognizing AQP3. Results: In psoriasis, AQP3 staining was usually observed in the cytoplasm rather than in the membrane. In SCC, AQP3 level was reduced as compared to the normal-appearing overlying epidermis. In atopic dermatitis, AQP3 level was increased as compared to the normal-appearing overlying epidermis. Conclusion: AQP 3 is the predominant aquaporin in human skin. Increased or reduced expression and altered cellular distribution of AQP3 is found in psoriasis, SCC and atopic dermatitis. These results suggest these abnormalities in the AQP3 signaling module correlate with hyperproliferation in psoriasis and SCC, and water loss in atopic dermatitis.