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- 저자 : ( Jan-jeng Huang ) (검색결과 1 건)
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( Tzong-shean Chin ),( Cheng-nan Chen ),( Jan-jeng Huang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Homocysteine and pro-inflammatory mediators such as cyclooxygenase-2 (COX-2) have been linked to vascular dysfunction and risks of cardiovascular diseases. Fulvic acid (FA), a class of compounds of humic substances, possesses various pharmacological properties. However, the effect of FA on inflammatory responses of the monocytes remains unclear. We investigated the regulatory effect of FA on homocysteine-induced COX-2 expression in human monocytes. The effects of FA on mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB pathways in homocysteine-induced U937 monocytes were also identified. Pretreating monocytes with FA inhibited the homocysteine-induced COX-2 expression in a dose-dependent manner. Stimulation of U937 monocytes with homocysteine induced rapid increases in the phosphorylation of ERK and JNK; the inhibitor for ERK and JNK attenuated this homocysteine-induced COX-2 expression. Transcription factor ELISA and chromatin immunoprecipitation assays showed that FA blocked the homocysteine-induced increases in the binding activity and in vivo promoter binding of NF-κB in monocytes. Our findings provide a molecular mechanism by which FA inhibits homocysteine-induced COX-2 expression in monocytes, and a basis for using FA in pharmaceutical therapy against inflammation.
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