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Development of a 250-W high-power modular LED fish-attracting lamp by evaluation of its thermal characteristics

( Dong Gil Lee ),( Kyoung Hoon Lee ),( Yong Beom Pyeon ),( Seong Hun Kim ),( Jaeh Yun Bae ) 한국수산해양기술학회 2015 수산해양기술연구 Vol.51 No.2
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  코리아스칼라
  
  KISS
Recently LED fish-attracting lamps have been more widely used in fisheries as low-cost and high-efficiency fishing gear, and development of long-life high-efficiency lamps is required through the design of LED packages to optimize heat resistance. This study developed an improved LED fish-attracting lamp with excellent heat performance, which was verified using a numerical model. Heat-resistance design factors such as the heat-radiation fin shape, PCB type, and LED chip count were investigated and optimized. Comparison with a commercial 180-W LED fishing lamp showed that the increase in initial temperature was 40% higher than that of the surrounding LED chip because of design errors in contact thermal resistance. The 250-W LED lamp developed in this study has a characteristic with thermal rising in linearly stable according to the heat source. In addition, luminance efficiency was improved by 20-65% by using flow-visualization simulation. A decrease of 45% in total power consumption with a fuel-cost reduction of over 55% can be expected when using these optimized heat release design factors.
2
Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer

Shin, Kyung Min,Hong, Mi Jeong,Lee, Shin Yup,Jin, Cheng Cheng,Baek, Sun Ah,Lee, Jang Hyuck,Choi, Jin Eun,Kang, Hyo-Gyoung,Lee, Won Kee,Seok, Yangki,Lee, Eung Bae,Jeong, Ji Yun,Yoo, Seung Soo,Lee, Jaeh Elsevier BV 2018 Gene Vol.646 No.-
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Abstract Background We conducted this study to identify genetic variants in cancer-related pathway genes which can predict prognosis of NSCLC patients after surgery, using a comprehensive list of regulatory single nucleotide polymorphisms (SNPs) prioritized by RegulomeDB. Method A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. These SNPs were analyzed in a discovery set (n=354), and a replication study was performed in an independent set (n=772). The association of the SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Results In the discovery set, 76 SNPs were significantly associated with OS or DFS. Among the 76 SNPs, the association was consistently observed for 5 SNPs (ERCC1 rs2298881C>A, BRCA2 rs3092989G>A, NELFE rs440454C>T, PPP2R4 rs2541164G>A, and LTBP4 rs3786527G>A) in the validation set. In combined analysis, ERCC1 rs2298881C>A, BRCA2 rs3092989, NELFE rs440454C>T, and PPP2R4 rs2541164G>A were significantly associated with OS and DFS (adjusted HR ·aHR· for OS=1.46, 0.62, 078, and 0.76, respectively; P =0.003, 0.002, 0.007, and 0.003 respectively; and aHR for DFS=1.27, 0.69, 0.86, and 0.82, respectively; P =0.02, 0.002, 0.03, and 0.008, respectively). The LTBP4 rs3786527G>A was significantly associated with better OS (aHR=0.75; P =0.003). Conclusion Our results suggest that five SNPs in the cancer-related pathway genes may be useful for the prediction of the prognosis in patients with surgically resected NSCLC. Highlights <UL> <LI> Five among 509 SNPs from RegulomeDB were validated in two independent cohorts. </LI> <LI> Five SNPs in the cancer-related pathway genes were independent prognostic factors. </LI> <LI> RegulomeDB is a practical tool for selecting functional SNPs in regulatory regions. </LI> </UL>