Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

Coevaporation에 의한 cd₁-xZn_(x)S 박막 제작 및 특성에 관한 연구

李載亨,李虎烈,朴鏞冠,申成浩,申載爀,朴光子 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

In this paper, structural optical and electrical properties of Cd_(1-x)Zn_(x)S thin films prepared by coevaporation method were studied. Also, effects of ZnS mole ratio(x) to CdS on properties of thin film Cd_(1-x)Zn_(x)S/CdTe solar cells were investigated. When the ZnS mole ratio was less than 0.85, the crystal structure of Cd_(1-x)Zn_(x)S films was hexagonal with the c axis aligned perpendicular to the substrate. For x>0.85, however, the Cd_(1-x)Zn_(x)S films were grown with cubic zincblende structire. As the ZnS mole ratio increased the lattice constant of Cd_(1-x)Zn_(x)S films rapidly increased with ZnS mole ratio. The open circuit voltage of Cd₁xZnxS/CdTe solar cells increased with x due to reducing of the electron affinity difference between Cd₁xZnxS and CdTe films. However, the increase of series resistance due to the high resistivity of Cd_(1-x)Zn_(x)S films results on reducing conversion efficiency.

Bi_2Sr_(2-x)Ca_(1+x)+xCu_2O_(8+d)계 산화물의 초전도 특성 및 XPS 측정

신재수,오승호,장충근 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.2

We have elucidated the distribution of the Sr and Ca atoms in the Bi_2 Sr_(2-x) Ca_(1+x) Cu_2O_(8+d) system (0≤x≤0.8) by X-ray photoelectron spectroscopy (XPS). The carrier concentration and the superconducting temperature Tc have a maximum at x=0.2 and then monotonously decrease with increasing x. From the XPS measurements, the Sr3d and Ca2p spectra are found to be decomposed into two states. We have clarified the occupation of the Sr and Ca atoms in the Sr- and Ca-layers and found that he deficiency in the Sr-layer have a great influence on superconductivity.

비대칭 사장교의 정적 및 시공 단계 해석

신재철,남기수,정인수,한성호 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

The cable-stayed bridges are composed of cables, towers and girders. when the cable-stayed bridges are loaded, the whole structure display very complex behavior due to excessive cable deflection. Eventhough the material in the members of a cable-stayed bridge structure behaviors in a linear elastic manner. the overall load-displacement relationship for the structure will be nonlinear. The nonlinear behavior is a result of: due to the sag caused by their own dead weight and the nonlinear axial and bending force-deformation relationships for the bend members. In the construction stage analysis, some technical approaches and structure safety are needed to stimulate numerically the complicated changes of structural system during construction. In this study static and construction stage analysis is performed and compared. Static and construction stage analysis on unsymmetric Cable-stayed bridge is performed and linear and nonlinear analysis is performed to evaluate the structure characteristics. After Static analysis of final construction stage was performed, construction stage analysis was performed.

국내산고령토정제에 관한 연구

신건철,이재장,전호석,조성백 江原大學校 産業技術硏究所 1990 産業技術硏究 Vol.10 No.-

The samples used for this work were low grade clay(Fe?O? : 2.90%, TiO? :1.65%) produced from Youngsan-do district, and for the iron-bearing impurities removal having a bad influence on Kaoline sample was carried out column floatation using Oleic acid, Potassium oleat, Aero 840 promotor, Aero 870 promotor and Keroseneas collectors. For removal of the iron-vearing impurities from the kaoline, investigated first chemical composition size distribution of Kaoline sample, also performanced a basic study on pulp density, collector and pH change on a sort frother. The flotation separation of impurities from kaoline can be achieved by using both oleic acid and Aero 840 promotor as collectors within narrow aoid limits(pH 2-3). Pine oil was more effective frother than MIBC with olelic acid as aa collector.

AES-128 Rijndael 암·복호 알고리듬의 하드웨어 구현

신성호,이재흥 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문에서는 미국 국립표준기술연구소(NIST)에서 채택한 차세대 암호 표준인 Rijndael 암호 알고리듬을 하드웨어로 구현한다. 효율적인 연산을 위해 라운드를 2개의 부분 라운드로 나누고 부분 라운드 간에 파이프라인을 사용하였으며, 1 라운드 연산시 평균적으로 5클록이 소요된다. AES-128 암호 알고리듬을 ALTERA PPGA를 사용하여 하드웨어로 구현 후 성능을 분석하였다. 구현된 AES-128 암호 알고리듬은 암·복호화시 최대 90 Mhz의 동작 주파수와 약 230 Mbps의 암·복호율을 얻을 수 있었다. In this paper, Rijindal cipher algorithm is implemented by a hardware. It is selected as the AES(Advanced Encryption Standard) by NIST. The processor has structure that round operation divided into 2 subrounds and subrounds are pipelined to calculate efficiently. It takes 5 clocks for one-round. The AES-128 cipher algorithm is implemented for hardware by ALTERA FPGA, and then, analyzed the performance. The AES-128 cipher algorithm has approximately 230 Mbps encryption·decryption rate for 90Mhz max clock frequency.

심상성 루프스에서 Nested-Primer Gene Amplification Assay에 의한 결핵균 DNA의 검출

신문석,전효진,김병천,이규석,김재룡,권호준,송준영 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Lupus vulgaris, which is a progressive form of postprimary tuberculosis in patients with a moderate to high degree of immunity and tuberculin sensitivity, is the most common, most serious, and most variable type of cutaneous and mucous membrane tuberculosis. Domonstration of M.tuberculosis directly or in culture in some of these eruptions can be difficult. It is essential to demonstrate the presence of M.tuberculosis in a clinical sample for a definitive diagnosis of tuberculosis. With the discovery of the polymerase chain reaction (PCR), the DNA diagnostic approach for infection has developed in a short period. With the dual purpose of definitive and rapid diagnosis of tuberculosis, this study examined the usefulness of a nested PCR for detection of M. turberculosis. Compared with a single-step PCR, the two-step PCR was able to enhance sensitivity approximately 1,000-fold on the basis of bacterial counts and DNA quantity. We concluded that two-step nested PCR appeared to be the most useful PCR protocol for early and sensitive diagnostic method detecting M.tuberculosis in acid-fast stain negative specimens.

鋼橋梁 下部플랜지 맞대기 鎔接이음부의 鎔入不足에 따른 疲勞擧動에 관한 硏究

신재철,한성호,정인수 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

A major defective welding pattern in the steel bridges is identified as the lack of welding area due to the insufficient welding penetration. In this study is fatigue behavior and fatigue life of steel bridge under flange of weld insufficient of butt weld joint. Fatigue behavior and fatigue life test is minor's law and fracture analysis and nowaday, finite element method is used to many times. By considering the welding defect in the above, structural analysis is conducted to evaluate butt weld joint influence due to welding defect on the safety of steel bridges. The results indicate that, due to the insufficient welding penetration, the stress obtained in the analysis is over the allowable fatigue stress level, and its influence on safety of the bridges is significant

사례 기반 학습을 이용한 지능형 판매 지원 에이전트 시스템의 설계 및 구현

신하철,김재호,김기태 중앙대학교정보통신연구소 2000 정보통신연구소논문집 Vol.2 No.1

전자 카탈로그를 이용한 인터넷 정보의 접근은 일반화되고 있지만 수많은 정보의양과 다양성 때문에 고객이 원하는 효율적인 상품 검색을 방해하는 원인이 되고 있다. 또한 수시로 변경되는 상품 카탈로그를 처음 접근하는 고객이 원하는 상품 정보를 찾아내기란 쉬운 일이 아니다. 이러한 문제점들의 가장 근복적인 이유는 전문적인 상품 카탈로그가 다양한 속성들로 되어 있기 때문에 각 고객의 관심분야와 검색 습관은 같은 고객의 요구사항을 기존의 웹 브라우저만을 이용하여 만족시키지 못한데 기인된다. 본 논문에서는 이러한 문제를 해결하기 위해 사례 기반 학습 개념을 이용하여 각 고객의 관심 분야를 반영하고 고객 편의의 정보검색을 도와주는 지능형 판매 지원 시스템(Intelligence Sales support Agent System, ISAS)을 설계하였다. Although the access of internet information is generalized using electronic catalog, because of the number of amount and variety of information, the customers can't effectively search the merchandise that they need. Also it is difficult searching the merchandise information that the customer need, if they access merchandise catalog first. The reason of this problem is that the existing web browser is not satisfied the customer's requirement like their interests and search habits, because professional merchandise catalogs consist of variable attributes. In this paper, we designed Intelligence Sales support Agent System that reflects the customer's interests and assists the effective information search using case-based reasoning, to solve this problem.

동하중을 받는 FRAME 구조물의 확률유한요소해석 및 신뢰성해석

신재철,김진홍,정인수,한성호 충남대학교 산업기술연구소 2003 산업기술연구논문집 Vol.18 No.1

Most dynamic systems have various random properties in excitation and system parameters. Therefore, in this paper, reliability analysis for structural response is proposed fro the linear dynamic system with random properties in both excitation and system parameters. The system parameters and responses with random properties are modeled by the perturbation technique. A displacement and bending moment of frame structure is acquired in Stochastic Finite Element Method Program(SFEMP) and Dynamic Stochastic Finite Element Method Program(DSFEMP) using perturbation method, and Direct Monte Carlo Simulation Program(DMCSP) is used to verify and compare previous results. Comparing outputs of SFEMP and DSFEMP with them of DMCSP, it show that they are similar to each other. Also DMCSP need much time to analyze a complicated structure, but SFEMP and DSFEMP can reduce quite time. In this study, it is assumed that excitations, system parameters and response are Gaussian. The results of response for the analysis are compared to those of numerical simulation. Also the probability of failure are calculated for using Advanced First Order Second Moment(AFOSM) of the general reliability analysis method.