21세기 한국사회 : 지식사회냐 정보사회냐

임현진,서이종 한국사회문화학회 2000 사회와 문화 Vol.12 No.-

This paper deals with the characteristics in the introduction of the concept of "knowledge society" and "information society" for Korean society at the 21st Century and with a usability of "knowledge-information society" as a conceptual synthesis. Chapter 2 shows that the concept of information society war introduced critically in the late 1980s and developed into an empirical research theme in the beginning of 1990s, with various conceptual variances, that the concept of knowledge society war introduced in the science of economy and business in the 1990s with various conceptual variances. Chapter 3/4 shows that information society concentrate on the information basis of knowlege transmission and storage, while knowledge society concentrate on the creation of knowledge as contents, that two concepts can be conceptually incorporated into "knowledge-based information society" or "information-based knowledge society", and finally into "knowledge-information society".

Association of hepatitis B and C virus infection in psoriasis

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Yong Bum Yoon ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Recent finding in psoriasis research have shown that psoriasis is not just a skin disease but frequently associated with systemic comorbidities. Viral hepatitis is known to be associated with chronicinflammation and aberrant immune response. Objectives: This study is to investigate prevalence and association of HBV and HCV infection in psoriasis. Methods: We analyzed and evaluated laboratory in patients with or without psoriasis who visit department of dermatology, National Medical Center from September 2012 to March 2015. 706 patients with psoriasis and 345 patients without psoriasis were enrolled. 240 patients with psoriasis and 345 patients without psoriasis were evaluatedHBV and HCV serological makers. Results: 4(1.7%) out of 240 patients with psoriasis were Hbs Ag positive while 7(2.07%) out of 345 patients without psoriasis in the control group were Hbs Ag positive. There was no significant difference between two groups. There was no significant associated with hepatitis B virus infection after adjusting for gender, age, and severity of psoriasis. 1out of 240 patients with psoriasis was anti-HCV positive and 1 out of 345 patients in the control group were anti-HCV positive. Conclusion: Psoriasis does not appear to be associated with an increased risk of hepatitis in our study. Epidemiology of viral infections in psoriasis needs to be continually studied and updated given importance in management considerations.

[P299] Hand-foot-mouth Disease in an Immunocompetent Adult

( Hyun Yi Suh ),( Jae In Lee ),( Joo Yoon Bae ),( Hong Lim Kim ),( Hye Jung Jung ),( Mi Youn Park ),( Jai Il Youn ),( Ji Young Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Hand-foot-mouth (HFM) disease is a highly infectious disease characterized by multiple vesicles on the hands, feet and in the oral cavity. It is primarily a disease of children and coxsackie virus A16 is the most common virus. Clinically, the onset is characterized by vesicles with fever and symptoms usually subside within 7 to 10 days. Although several cases of adult HFM disease have been reported, it has been rarely reported in healthy adults. We report a case of hand-foot-mouth disease in an immunocompetent adult. A 78-year-old female visited our clinic for multiple erythematous vesicular papules on the hands, feet and oral ulcer. The skin lesions developed the 3 days ago and were aggravated. Histopathological findings showed hyperkeratosis, parakeratosis, spongiosis, keratinocyte apoptosis in epidermis. Papillary dermal edema, perivascular lymphocytic infiltrates and dilated vessels were seen in the dermal layers. We did symptomatic treatments. Dermatologists should be aware that HFM disease can occur in adults with intact immune systems. We report this impressive case of hand-foot-mouth disease in an immunocompetent adult.

Efficacy of Tranexamic acid on senile purpura

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Senile purpura is a common, chronic skin condition affecting more than 10 percent of individuals over the age of 50. Despite being a benign condition, purpura lesions is frequently a source of significant visual and social concern. To date, there are no known effective treatments for this condition except for avoidance of physical injury. Objectives: The purpose of the study was to evaluate the efficacy in improving the skin``s appearance in patients with senile purpura. Methods: 20 patients were enrolled in the study. Patients were instructed to take medication 3 times in a day, tranexamic acid 250mg(Transamin?), for 3 weeks. We took pictures of their lesions on the arms at baseline, and at 1 and 3 weeks. We assessed patient``s satisfaction and clinical improvement assessed by a physician. Results: The mean number of their lesions was 7 on thearm, both at baseline. Although the new lesions presented, the existing lesions markedly faded or disappear after 1 week in 19 patients. In 20 patients, the mean number of all lesions on the arms was 6 at 1 week and 4 at 3 weeks. By patient self-assessment of the effectiveness, 85% of patients were satisfied with the medication. There was no laboratory abnormality including platelet count, PT, and aPTT in all patients. No adverse effects were noted by either the patients or investigators. Conclusion: We suggest that tranexamic acid may be considered an effective treatment to diminish skin bruising in patients with senile purpura.

P083 : A case of subungual verruca in all fingers

( Hyun Yi Suh ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Hye Jung Jung ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

A case of HIV associated pruritic papular eruption

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Papular pruritic eruption (PPE) of HIV has been considered to be within the spectrum of pruritic papular disorders in HIV. The primary skin lesions for PPE are firm, well-demarcated, erythematous papules originating on the extremities and occasionally spreading on the trunk. Because of severe pruritus, skin lesions are excoriated papules, marked postinflammatory pigment changes and eventually prurigo-like nodules. Histologically, they show superficial and deepinflammation and perivascular and interstitial infiltration of lymphocytes and eosinophils. 48-year-old male who visited our clinic for intensively pruritic scattered erythematous papules with crust and excoriations on the trunk and upper extremities. It appeared in 2 years ago. We implemented punch biopsy in the skin lesions and it histologically showed perifollicular and perivascular lymphocytic and eosinophilic infiltration. Therefore, we could make a diagnosis as HIV-PPE. We treated with antihistamine for his skin lesion and symptom. Recently, Patients infected with HIV have been increasing so we report this impressive case of HIV associated dermatosis.

The relationship between IgE-mediated hypersensitivities and contact allergy in allergic disease

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: The relationship between individual susceptibility to IgE-mediated and cell-mediated hypersensitivities has been studied by few groups. Recent reports suggested that repeated exposure to allergens induces chronic allergic reactions in the skin and a shift in T helper cell type 2 profile. Objectives: This study analyzed the association between contact allergy and specific IgE responsiveness in allergic dermatitis. Methods: It was a cross sectional study among outpatients visited the department of dermatology in National Medical Center between January, 2011 to March, 2015. 212 patients with allergic disease tested with 24 different allergens in TRUE test panel and IgE. Among them, 76 patients also tested multiple allergosorbent test (MAST) for measuring allergen-specific IgE. Results: 166(78.3%) out of 212 patients (male: 82, female: 130) had positive patch test results and total IgE level was positive in 69(41.5%) patients out of 166. The patients who had both positive results of patch test and MAST were 61.7%. The positive result of patch test and positive rates of specific IgE were highest in allergic contact dermatitis, followed by urticaria, pruritus patients. Conclusion: These results provide the IgE-mediated hypersensitivities can be related to the contact allergy in allergic disease. Large-scale study should be done to find out statistical significance and underline mechanism.

Association of Hepatitis B Virus Infection and Psoriasis

( Hyun-yi Suh ),( Yong-bum Yoon ),( Ji-young Ahn ),( Mi-youn Park ),( Jai-il Youn ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.6

A Case of Subungual Verruca in All Fingers

( Hyun-yi Suh ),( Hong-lim Kim ),( Kyung-ho Kim ),( Mi-youn Park ),( Jai-il Youn ),( Ji-young Ahn ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.1

Viral warts are common, benign, and frequently irritating skin lesions caused by the human papillomavirus (HPV). Direct skin trauma is the usual cause of local viral infection ¹. However, development of infection depends on various local and systemic factors such as working environment or immunocompromise². Subungual verruca is HPV infection of the nail bed. We report a rare case with subungual verruca in all 10 fingers. A 64-year-old man visited our clinic with subungual hyperkeratotic plaques in all fingers (Fig. 1A, B). The condition initially appeared in the hyponychium of the right first finger 3 years prior, and had since spread to all fingers. There was no evidence of trauma or underlying disease. The patient`s occupation was that of a professional scrubber, who scrubs down bathrooms in a public bathhouse. Potassium hydroxide (KOH) test was performed on all fingers to assess the possibility of a fungal infection(s); however, the results were negative. Subsequent biopsy and histological analysis of the lesion indicated papillomatous hyperplasia with hypergranulosis and parakeratosis in the epidermis. Viral inclusions were found in the upper epidermis. The biopsy tissue was subjected to liquid bead microarray assay for HPV detection and genotyping. The HPV oligonucleotide microarray detected type 11 and type 58 HPV. Thus, the final diagnosis was subungual warts. The patient was provided only three sessions of cryotherapy treatment and the lesions showed improvement after each session. However, owing to the pain during treatment, the patient did not return after the third session. Warts can develop from a few weeks to greater than a year after infection with HPV<sup>1</sup>. A less common area of infection is under the nail plate. Subungual warts may appear as a linear growth that penetrates deep underneath the nail plate, producing a longitudinal band of onycholysis, or a nodular lesion that lifts the nail plate ultimately leading to onycholysis 2. Lesion characteristics are influenced by the virus type as well as environmental and host factors<sup>4</sup>. Butcher`s warts are related to HPV type 7³. People in certain occupations have an increased risk of ungual warts. Up to 23% of handlers of meat and fish develop warts due to continuous skin maceration⁵. HPV is highly resistant to heat, desiccation, and detergents. Our patient worked in a communal washing area and his hands were subject to continuous skin maceration. In addition, one study⁵ suggested that public shower users are at greater risk for plantar warts than those who do not use such communal showers. Therefore, our patient`s occupation and constant exposure to environ-mental factors contributed to the development of his skin lesions. Treatment for warts should be prescribed based on factors such as lesion size, number, and immunity². Further-more, subungual warts may be difficult to treat due to their location. The most common forms of wart treatment are topical salicyclic acid application, cryotherapy with nitrogen, and laser therapy. In conclusion, we report a rare case in which an otherwise healthy man developed subungual warts on all fingers; the most probable cause was the environmental factor related to his occupation.

Paradoxical psoriasis induced by biologic therapies

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Biologic therapies currently approved for the treatment of moderate-to-severe plaque psoriasis work well. Administrations of those are beneficial in a variety of chronic inflammatory conditions. Recent reports have illustrated the paradoxical development of psoriasis after biologic therapies. A 30-year-old man presented widespread scaly erythematous patches on the whole body involvement after treatment with the third dose of infliximab. He was diagnosed with palmoplantar psoriasis 6 years ago. The patients had been treated either neotigason or cyclosporine with eximer phototherapy for 2 years 6 months before visiting our psoriasis clinic. He was started on the injections of infliximab, but there was no improvement after the first dose. After receiving third dose of infliximab, the patient had experienced worsening of his plaque psoriasis on the whole. We changed other biologics, ustekinumab, anti-IL-12/23 p40 monoclonal antibody. He was treated with ustekinumab. Although receiving the second dose of ustekinumab, the skin lesions were not improved and worsening of appearing pustules on the palm and sole. We treated with cyclosporin and with calcipotriol agent (Daivonex® cream) for his skin lesion. Herein, we report this impressive case of induced paradoxical psoriasis after treating on TNF-a inhibitor and IL-12/23 inhibitor.