조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

단시간 최대운동 방법이 유산소성 파워와 무산소성 파워에 미치는 상호관련성 연구

조현철,김종규 龍仁大學校 2004 용인대학교 논문집 Vol.22 No.-

The purpose of this study was to assess the interrelation of measuring both aerobic and anaerobic power at acute maximal exercise test protocols. It was hypothesized that oxygen consumption increases rapidly during maximal effort and maximal oxygen consumption(VO2 max) may be reached in one minute. subjects were male 11, female 7, performed the following test: 1) standard incremental workload VO2 max test. 2) 30, 45, 60sec wingate anaerobic test as VO2 measured maximal exertion test. All tests were performed on an electrically-braked lodeTM wingate sport ergometer. Peak oxygen consumption values for 30sec(male: 31.16±6.01 ml/min/kg; 62%, female: 27.45±4.68 ml/min/kg; 75%) and 45sec(male: 33.37±5.61 ml/min/kg; 66%, female: 29.14±5.41 ml/min/kg. 49%) tests were significantly lower than VO2 max(male: 50.54±6.29, female: 36.68±5.94). During the 60sec(male: 42.10±7.98 ml/min/kg 83%, female: 33.49±5.41 ml/min/kg; 91%)test, there was no significantly difference in VO2 max from standard incremental workload, demonstrating a plateau effect. There were no significant difference in peak power or peak power in time on 30sec, 45sec, 60sec wingate test, as expected, mean power were significantly difference these test. It was concluded that VO2 max was high interrelation during the 60sec test than 30sec and 45sec. Furthermore high correlation in peak power, peak power in time for 45sec and 60sec precludes the necessity for aerobic and anaerobic tests longer than the 30sec wingate test.

전방십자인대 재건술후 슬관절 등속성 변인의 특성

조종현,박원하 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to compare of bilateral isokinetic parameters and thigh circumferences in patients with anterior cruciate ligament reconstruction (ACLR) using bone-patellar tendon-bone autograft(mean age : 32.68±9.86 years.. mean time of Isokinetic test after ACLR : 4.00±0.98 months). We have examined 34 patients with ACLR of knee using the Isokinetic Rehabilitation and Testing System(Modle No. Cybex 6000). Isokinetic parameters of the knee extensors and knee flexors at the angular velocity of 60 degree/sec and 180 degree/sec were measured and analyzed. The results showed that the values of peak torque(PT), peak torque percentage of body weight, average power(AP), total word(TW), torque acceleration energy(TAE) of the involved knee extensors and flexors were significantly low compared to the uninvolved knee at the angular velocity of 60 degree/sec and 180 degree/sec. At the angular velocity of 60 degree/sec, the knee extensors showed 56.02±12.26% deficit in PT 52.94±12.80% deficit in TW, 50.64±13.02% deficit in AP, and 53.50±15.52% deficit in TAE, the knee flexors showed 30.73±13.63 deficit in PT, 36.23±16.12% deficit in TW, 34.32±17.03% deficit in AP, 33.91±23.00% deficit in TAE(p<0.0001). At the angular velocity of 180 degree/sec, the knee extensors showed 43.50±15.34% deficit in PT, 45.14±16.41% deficit in TW, 43.97±17.79% deficit in AP, and 42.70±16.24% deficit in TAE, the knee flexors showed 30.02±20.70% deficit in PT, 38.50±23.25% deficit in TW, and 29.82±22.02% deficit in TAE(p<0.05). The thigh circumference of the involved leg was 4.84% smaller than that of the uninvolved leg(p<0.0001). These results means that on same angular velocity, knee extensors has deficiency ration than knee flexors, and also 60˚/sec is higher deficiency ration than 180˚/sec. Therefore, after ACLR, clinicians must estabilish rehabilitation programs that will enhance the knee extensors and knee extensors and isokinetic function at 60˚/sec, espcially in early rehabilitation.

파킨슨씨병에서 Selegiline HCI (MAO-B^(�))의 효과 및 안전성

조기현,김명규,김태선,김병채,이승한,황인용,김준태,김종기 全南大醫大 2000 전남의대학술지 Vol.36 No.2

도로 PSC 표준거더의 최적설계에 관한 연구

조선규,이종민,김수현 서울産業大學校 2005 논문집 Vol.54 No.2

The prestressed concrete girder bridges have been used widely at the domestic national road and highway because it is great in the functional and economical efficiency. It has also the advantage of convenience of design and construction due to using standard sections. However it could be easily verified that previous standard section of PSC girder is excessively designed, which has much more redundancy than is necessary against design loads. Therefore it would greatly influence on economic efficiency for domestic demands, if a section of PSC girder became more economical with satisfying all design criteria. Thus the optimum design for the section of PSC girder using an optimum design method has been performed to examine more effective and economic section than previous standard one.

초등학교 교사들의 직무스트레스와 건강 수준

조현숙,이종태,손혜숙,박진국 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : The purpose of this study was to assess the effect of job strain on stress and health status among elementary school teachers. Methods and Material : The subjects in this study were 300 teachers who were selected from among 588 teachers in 13 out of 42 elementary schools in the city of Gimhae. Through the questionnaire, demographic characteristics, Karasek's Job Content Questionnaire(JCQ) and the Psychosocial Well-being Index (PWI) to assess their occupational characteristics and psychosocial stress level were surveyed. Medical checkup results of them were adopted to measure their Health status. Results : 24.9 percent of the general teachers were low strain group, and 16.3 percent of them were high strain group. In the senior teachers, 19.7 percent belonged to a low strain group and 21.3 percent belonged to a high strain group. In regard to health status, more senior teachers than junior teachers suffered from obesity(24.6%) and diabetes(11.5%) (p<0.O5), and they also were higher in DBP(p<0.057), total cholesterol(p=0.039) and blood sugar level(p=0.000), the low strain group perceived more social support(p=0.000), and the high strain group felt bigger physical overload(p=0.000). Concerning psychosocial stress, the low strain group was more aware of teacher social role and put more confidence in themselves(p=0.004). The high strain group was more depressed(p=0.001), but no difference was detected in health status. The health status difference between the high strain and low strain groups was significant in depression of psychosocial stress(OR=3.823, 95%CI=1.584-9.224). Conclusion : The senior teachers group was more morbid to obesity, diabetes and hyperlipidemia, which implies that some measure should be studied to help senior teachers manage those diseases properly. The high strain group suffered more from physical overload and was high 'Social support'. Therefore it's required for high strain group to be given more support from colleagues and supervisors, and a stress management program should be implemented to reduce their psychosocial stress.

고추와 토마토에 대한 칼슘 엽면 시비 효과

조현종,진선재,정종배 대구대학교 생명과학연구소 2003 생명과학연구 Vol.2 No.1

This study was conducted to evaluate the effect of foliar application of calcium on the Ca content and yield of tomato and red pepper plants. And the correlation between the Ca content of tissues and their resistance to fungal diseases was also investigated. The plants were sprayed with commercial Ca fertilizer (49.8% of water soluble CaO) three times during the growth period at a rate of 100 L/10a with 400x diluted solution per spray. Plants sprayed with water served as control. Studied spray had no effect on fruit yields of both tomato and red pepper. Sprays increased Ca concentrations in fruit and leaf. Foliar application of Ca decreased blossom end rot of tomato and fungal diseases in red pepper. These results indicate that foliar application of Ca can be recommended to increase fruit resistance to physiological disorders.

다공질 실리콘을 이용한 미세 기계구조의 제조

조찬섭,이봉희,이종현,최규만 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

Micromechanical structures such as cantilever beams and bridge array (~μm thick, 100~500 μm long) were fabricated by formation of porous silicon layer. The beam array of n/p samples have irregular etched surface and cusp. On the otherhand, beams of n/n^(+)/n structure have clear etched surface and no cusp.