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Synergistic Effect of Minoxidil and Retinol on Hair Growth in Human Dermal Papilla Cells
( Hyeon Gyeong Yoo ),( In Young Chang ),( Se Rah Lee ),( Soon Jin Choi ),( Hyun Keol Pyo ),( Ji Yun Kim ),( Oh Sang Kwon ),( Jin Ho Chung ),( Kwang Hyun Cho ),( Hee Chul Eun ),( Kyu Han Kim ) 대한피부과학회 2005 초록집 Vol.43 No.20
Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia
Yoo, Hyeon Gyeong,Kim, Jin Sook,Lee, Se Rah,Pyo, Hyun Keol,Moon, Hyung In,Lee, Jong Hee,Kwon, Oh Sang,Chung, Jin Ho,Kim, Kyu Han,Eun, Hee Chul,Cho, Kwang Hyun Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.6
<P>Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10<SUP>−9</SUP>—10<SUP>−7</SUP> <SMALL>M</SMALL>) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10<SUP>−8</SUP> <SMALL>M</SMALL>) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-β1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-β1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-β1 antibody (10 μg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-β1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-β1 expression may explain another possible mechanism how finasteride works in AGA.</P>
The Additive Effects of Minoxidil and Retinol on Human Hair Growth <i>in Vitro</i>
Yoo, Hyeon Gyeong,Chang, In-Young,Pyo, Hyun Keol,Kang, Yong Jung,Lee, Seung Ho,Kwon, Oh Sang,Cho, Kwang Hyun,Eun, Hee Chul,Kim, Kyu Han Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.1
<P>Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth <I>in vitro</I> and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.</P>