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The Effect of Dibucaine.HCl on the Physical Properties of Neuronal Membranes
Jang, Hye-Ock,Hyun, Cheol-Ho,Yoon, Jin-Hyeok,Kang, Yong-Gyu,Park, Sung-Min,Park, Young-Sik,Park, Jun-Seop,Ok, Jin-Seok,Lee, Dong-Hun,Bae, Moon-Kyung,Yun, Il Korean Society of Photoscience 2005 Journal of Photosciences Vol.12 No.2
Fluorescent probe techniques were used to evaluate the effect of dibucaine.HCl on the physical properties (transbilayer asymmetric lateral mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(l-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Dibucaine.HCl increased the bulk lateral mobility, and annular lipid fluidity in SPMV lipid bilayers, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. The magnitude of increasing effect on annular lipid fluidity in SPMV lipid bilayer induced by dibucaine.HCl was significantly far greater than magnitude of increasing effect of the drug on the lateral mobility of bulk SPMV lipid bilayer. It also caused membrane proteins to cluster. These effects of dibucaine.HCl on neuronal membranes may be responsible for some, though not all, of the local anesthetic actions of dibucaine.HCl.
Jang, Hye-Ock,Cha, Seong-Kweon,Lee, Chang,Choi, Min-Gak,Huh, Sung-Ryul,Shin, Sang-Hun,Chung, In-Kyo,Yun, Il The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.3
The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine the effect of chlorhexidine digluconate on differential rotational mobility of different positions of the number of membrane bilayer phospholipid carbon atoms. The six membrane components differed with respect to 2, 3, 6, 9, 12, and 16-(9-anthroyloxy)stearic acid (2-AS, 3-AS, 6-AS, 9-AS, 12-AS and 16-AP) probes, indicating different membrane fluidity. Chlorhexidine digluconate increased the rate of rotational mobility of hydrocarbon interior of the cultured Porphyromonas gingivalis outer membranes (OPG) in a dose-dependent manner, but decreased the mobility of surface region (membrane interface) of the OPG. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
Jang, Hye-Ock,Eom, Hyun-Sup,Roh, Sung-Bae,Yun, ll The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.1
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the present study, $3{\mu}l$ of 0.1% dried crude extract or $2{\mu}l$ of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells: $3{\mu}l$ of 0.1% dried crude extract and $2{\mu}l$ of 0.1% dried aqueous fraction significantly increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells ($8{\times}10^{-4}$) to the extent that it deserves a considerable attention. Furthermore, the crude extract and aqueous fraction increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells, and $300{\mu}M$ $Cd^{2+}$, specific calcium channel blocker, completely blocked the increase. Therefore, the increased $[Ca^{2+}]_i$ of the cultured osteoblast cells by safflower seed component continued to activate calcium channel.
Jang, Hye-Ock,Kim, Dong-Won,Kim, Byeong-Ill,Sim, Hong-Gu,Lee, Young-Ho,Lee, Jong-Hwa,Bae, Jung-Ha,Bae, Moon-Kyoung,Kwon, Tae-Hyuk,Yun, Il The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.2
The purpose of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Large unilamellar vesicles (OPGTL) were prepared with total lipids extracted from cultured Porphyromonas gingivalis outer membranes (OPG). The anthroyloxy probes were located at a graded series of depths inside a membrane, depending on its substitution position (n) in the aliphatic chain. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine effects of chlorhexidine digluconate on differential rotational mobility, while changing the probes' substitution position (n) in the membrane phospholipids aliphatic chain. Magnitude of the rotational mobility of the intact six membrane components differed depending on the substitution position in the descending order of 16-(9-anthroyloxy)palmitic acid (16-AP), 12, 9, 6, 3 and 2-(9-anthroyloxy)stearic acid (12-AS, 9-AS, 6-AS, 3-AS and 2-AS). Chlorhexidine digluconate increased in a dose-dependent manner the rate of rotational mobility of hydrocarbon interior of the OPGTL prepared with total lipids extracted from cultured OPG, but decreased the mobility of membrane interface of the OPGTL. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
Jang, Hye-Ock,Huh, Min-Hoi,Lee, Seung-Woo,Lee, Young-Ho,Lee, Jong-Hwa,Seo, Jun-Bong,Koo, Kyo-Il,Jin, Seong-Deok,Jeong, Je-Hyung,Lim, Jang-Seop,Bae, Moon-Kyung,Yun, Il The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7
The aim of this study was to provide the basis to further examine the mode of action of ethanol. Fluorescent probes reported to have different membrane mobilities were used to evaluate the effect of dimyristoylphosphatidylethanol (DMPEt) on the lateral and rotational mobilities of liposome lipid bilayers. An experimental procedure, based on the selective quenching of 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, was used. DMPEt increased the bulk lateral and rotational mobilities, and had a greater fluidizing effect on the outer than the inner monolayer. These effects of DMPEt on liposomes may be responsible for some, but not all, of the general anesthetic actions of ethanol.
Effects of Chlorpromazine·HCl on the Structural Parameters of Bovine Brain Membranes
Jang, Hye-Ock,Jeong, Dong-Keun,Ahn, Shin-Ho,Yoon, Chang-Dae,Jeong, Soo-Cheol,Jin, Seong-Deok,Yun, Il Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.5
Fluorescence probes located in different membrane regions were used to evaluate the effects of chlorpromazine HCl on structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and lipid bilayer thickness) of synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortex. The experimental procedure was based on the selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, radiationless energy transfer from the tryptophan of membrane proteins to Py-3-Py, and energy transfer from Py-3-Py monomers to 1-anilinonaphthalene-8-sulfonic acid (ANS). In this study, chlorpromazine HCl decreased the lateral mobility of Py-3-Py in a concentration dependent-manner, showed a greater ordering effect on the inner monolayer than on the outer monolayer, decreased annular lipid fluidity in a dose dependent-manner, and contracted the membrane lipid bilayer. Furthermore, the drug was found to have a clustering effect on membrane proteins.
Jang, Hye-Ock,Kim, Ji-Suk,Kwon, Woo-Cheol,Kim, Jeong-Kuk,Ko, Myung-Suk,Kim, Dong-Hoo,Kim, Won-Il,Jeon, Young-Chan,Chung, In-Kyo,Shin, Sang-Hun,Chung, Jin,Bae, Moon-Kyung,Yun, Il 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). $Pb^{2+}$ inhibited the immediate CRACI dose-dependent manner. Influx of $Pb^{2+}$ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of $Pb^{2+}$ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of $Ca^{2+}$ upon $Ca^{2+}$ readdition, is partially inhibited by $Pb^{2+}$ and (2) the influx of $Pb^{2+}$ was enhanced after CRACI had been induced.
Jang, Hye-Ock,Park, Young-Sik,Lee, Jong-Hwa,Seo, Jun-Bong,Koo, Kyo-Il,Jeong, Soo-Cheol,Jin, Seong-Deok,Lee, Young-Ho,Eom, Hyun-Sup,Yun, IL Taylor Francis 2007 NATURAL PRODUCT RESEARCH Vol.21 No.9
<P> Although safflower seeds have long been used in Korea as herbal medicines, very little research has been published on the effects of safflower seed on bone formation or bone density. The study reported here therefore examined bone nodule formation, calcium uptake, alkaline phosphatase activity, and intracellular concentration of calcium ion [Ca2+]i in murine osteoblastic cells of the MC3T3-E1 line that were cultured on modified Eagle's minimal essential medium alone (controls) or with addition of 0.1% crude extract of safflower seed (experimental group I) or 0.1% aqueous fraction of safflower seed (experimental group II). Fluorescence spectrometry measurement of ([Ca2+]i) showed significantly accelerated rates of osteoblast differentiation in experimental group I (3 µL of crude extract in 8 × 104 cells) and experimental group II (2 µL of aqueous fraction in 8 × 104 cells) compared to the control group.</P>