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다채널 광정렬 장치에서의 다자유도 회전 스테이지 동작 특성에 관한 연구
정상화,차경래,김현욱,최석봉,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-
In recent years, as the demands of VBNS(Very high speed Backbone Network Service) and VDSL(Very high-data rate Digital Subscriber Line) increase, the development of kernel parts of optical communication such as PLC(Planar Light Circuit), Coupler, WDM elements increase. The alignment and the attachment technology are very important to fabricate the optical elements for communication. In this paper, the mechanism of rotational stage are studied. with the three different method and the results of them are applied to the design of the system. The performance test of resolution and travel is performed.
Identification of ultraviolet B radiation-induced microRNAs in normal human dermal papilla cells
CHA, HWA JUN,KIM, OK-YEON,LEE, GANG TAI,LEE, KWANG SIK,LEE, JAE HO,PARK, IN-CHUL,LEE, SU-JAE,KIM, YU RI,AHN, KYU JOONG,AN, IN-SOOK,AN, SUNGKWAN,BAE, SEUNGHEE SPANDIDOS PUBLICATIONS 2014 MOLECULAR MEDICINE REPORTS Vol.10 No.4
<P>Ultraviolet (UV) radiation impairs intracellular functions by directly damaging DNA and by indirectly generating reactive oxygen species (ROS), which induce cell cycle arrest and apoptosis. UV radiation can also alter gene expression profiles, including those of mRNA and microRNA (miRNA). The effects of UV radiation on cellular functions and gene expression have been widely documented in human skin cells such as keratinocytes, melanocytes and dermal fibroblasts, but the effect it has on other types of skin cell such as dermal papilla cells, which are crucial in the induction of hair follicle growth, remains unknown. In the current study, the effect of UV radiation on physiological changes and miRNA-based expression profiles in normal human dermal papilla cells (nHDPs) was investigated. UVB radiation of ≥50 mJ/cm<SUP>2</SUP> displayed high cytotoxicity and apoptosis in a dose-dependent manner. In addition, ROS generation was exhibited in UVB-irradiated nHDPs. Furthermore, using miRNA microarray analysis, it was demonstrated that the expression profiles of 42 miRNAs in UVB-irradiated nHDPs were significantly altered compared with those in the controls (35 upregulated and 7 downregulated). The biological functions of the differentially expressed miRNAs were studied with gene ontology analysis to identify their putative target mRNAs, and were demonstrated to be involved in cell survival- and death-related functions. Overall, the results of the present study provide evidence that miRNA-based cellular mechanisms may be involved in the UVB-induced cellular response in nHDPs.</P>
Overdosage of Methylparaben Induces Cellular Senescence In Vitro and In Vivo
Cha, Hwa Jun,Bae, Seunghee,Kim, Karam,Kwon, Seung Bin,An, In-Sook,Ahn, Kyu Joong,Ryu, Junghwa,Kim, Hey-Sun,Ye, Sang-Kyu,Kim, Byung-Hak,An, Sungkwan The Society for Investigative Dermatology, Inc 2015 The Journal of investigative dermatology Vol.135 No.2
Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)
CHA, HWA JUN,HE, CONGFEN,ZHAO, HUA,DONG, YINMAO,AN, IN-SOOK,AN, SUNGKWAN UNKNOWN 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.38 No.1
<P>The skin consists of the epidermis, dermis and subcutis. The epidermis is primarily comprised of keratinocytes and is separated into four layers according to the stage of differentiation of the keratinocytes. Corneocytes are terminally differentiated keratinocytes that closely interact with other corneocytes through corneodesmosomes, and synthesize lamellar bodies and the intercellular multilamellar barrier, which protects the body from the external environment. As ceramides are the principal components of lamellar bodies and the multilamellar barrier, it is important to understand the biosynthesis of ceramides and their functions in skin. Ceramides are synthesized by amide bond-mediated interactions between sphingoid bases, long-chain amino alcohols [long-chain base] and fatty acids through a de novo pathway, a sphingomyelin (SM) hydrolysis pathway and a catabolic pathway. The majority of ceramides produced by the de novo pathway form the epidermal barrier. Ceramides used as signaling molecules are synthesized by the SM and catabolic pathways. Synthesized ceramides are released from corneocytes and form the multilamellar barrier. Additionally, ceramides and their metabolites regulate the apoptosis, proliferation and differentiation of skin cells as well as the formation of the skin barrier. Thus, the study of ceramides and their metabolites is crucial to understanding the function and regulation of the skin barrier.</P>
MicroRNA expression profiling of p-phenylenediamine treatment in human keratinocyte cell line
Hwa Jun Cha,Ok-Kyu Lee,Soo Yeon Kim,Jung-Min Ko,Su Young Kim,Ji Hye Son,Hyun Joo Han,Shunhua Li,Soo Young Kim,Kyu Joong Ahn,In-Sook An,Sungkwan An,Seunghee Bae 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1
p-Phenylenediamine (PPD), a black dye used in hair coloring and tattoos, irritates the skin, leading to cell cycle arrest, apoptosis, and reactive oxygen species (ROS) generation. MicroRNAs (miRNAs) are well known regulators of these side effects. The aim of the present study was to evaluate PPD-induced miRNA expression profile alterations in human keratinocytes. First, we demonstrated that PPD reduced HaCaT cell viability by inducing cell cycle arrest and death, elevating cellular ROS levels and decreasing the migration rate. In addition, 67 miRNAs were upregulated by at least 5-fold in PPD-treated HaCaT cell and 17 miRNAs were downregulated by at least 5- fold in PPD-treated HaCaT cell. Using bioinformatics, we identified a relationship between PPD-mediated miRNA changes and cell death, cell cycle arrest, generation of ROS, and migration repression. Target genes of PPD-regulated miRNAs were involved in cell proliferation, apoptosis, skin development, and aging. Thus, our results establish a role for miRNAs in regulating PPD-induced cell death, cell cycle arrest, ROS generation, and repression of migration in human keratinocytes.
차화준(Hwa-Jun Cha),강신범(Sin-Buem Kang) 한국마린엔지니어링학회 2006 한국마린엔지니어링학회 학술대회 논문집 Vol.2006 No.-
Mistral급과 RS:X급에 대한 장비비교를 통한 국내선수들의 육성 방안 및 장비의 기술적인 면을 비교분석하여 국제 공식대회(올림픽, 아시안게임 등)에서 좋은 결과를 얻고 자 하며 윈드서핑 경기정의 발전 방향을 모색하고 분석하는데 자료로 활용되고자 한다.
Jun, So-Young,Kim, Jin-Sik,Choi, Kyoung-Hwa,Cha, Jaeho,Ha, Nam-Chul Wiley-Blackwell 2013 Acta crystallographica. Section D, Biological crys Vol.69 No.4
<P>An intracellular α-amylase, AmyB, has been cloned from the hyperthermophilic bacterium Thermotoga neapolitana. AmyB belongs to glycoside hydrolase family 13 and liberates maltose from diverse substrates, including starch, amylose, amylopectin and glycogen. The final product of AmyB is similar to that of typical maltogenic amylases, but AmyB cleaves maltose units from the nonreducing end, which is a unique property of this α-amylase. In this study, the crystal structure of AmyB from T. neapolitana has been determined at 2.4?? resolution, revealing that the monomeric AmyB comprises domains A, B and C like other α-amylases, but with structural variations. In the structure, a wider active site and a putative extra sugar-binding site at the top of the active site were found. Subsequent biochemical results suggest that the extra sugar-binding site is suitable for recognizing the nonreducing end of the substrates, explaining the unique activity of this enzyme. These findings provide a structural basis for the ability of an α-amylase that has the common α-amylase structure to show a diverse substrate specificity.</P>
Hwa-Rang Cha,Kyung-Ho Park,Yeong-Jun Choi,Rae-Young Kim 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a wireless power transfer (WPT) system to achieve high power density and constant voltage output. The proposed system consists of a doublesided LCC compensation network and a semi-bridgeless rectifier. The output voltage is controlled by using the pulse width modulation control of the semi-bridgeless rectifier switch without changing the operating frequency. Therefore, the proposed system provides a stable output voltage even under various disturbances such as input voltage and load variation. In addition, there is an advantage that the power density is improved because no additional passive elements and stages for voltage control are required. In order to confirm the validity of the proposed system, simulation results are provided.
Cha, Gi-Wook,Kim, Young-Chan,Moon, Hyeun Jun,Hong, Won-Hwa Elsevier 2017 Journal of cleaner production Vol.168 No.-
<P><B>Abstract</B></P> <P>The purpose of this study is to propose a classification method for building demolition waste (DW) that is different from existing studies and to develop a demolition waste generation rate (DWGR) prediction model. To achieve the purpose, the chi-squared automatic interaction detection (CHAID), which is a decision tree (DT) method, was used in this study. Additionally, 796 buildings were measured using the data collection method that calculated the quantity of waste generation through actual measurements immediately before the building removal. The results using CHAID allows us to easily understand the complex influencing relationships between the DW types and various factors influencing the DW generation. Furthermore, the CHAID method was developed for forecasting the DWGR. Then, split-sample validation was performed to confirm the prediction performance of the CHAID algorithm applied in this study. The results show that the prediction performance of the current study is higher than that of the previous studies. In particular, the CHAID model for concrete classifies approximately 98.9% of the concrete generation correctly. Because the CHAID model of this study was developed from previous building cases, it can assist construction companies and building demolition contractors in decision making.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The actual field survey of 796 residential buildings has been conducted. </LI> <LI> New methodology applying CHAID algorithm has been developed. </LI> <LI> Split-sample validation was performed to confirm the prediction performance. </LI> <LI> CHAID model for concrete classifies 98.9% of concrete generation correctly. </LI> <LI> The results will make a contribution to the DW estimation based on big data. </LI> </UL> </P>
플라이애시 및 PET섬유를 혼입한 변형경화형 시멘트 복합체(SHCC)의 휨성능 평가
차준호(Cha Jun-Ho),송선화(Song Seon-Hwa),장용헌(Jang Yong-Heon),전에스더(Jeon Esther),윤현도(Yun Hyun-Do) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(구조계)
There have been numerous studies to develop eco-friendly concrete. The attempt to reduce the amount of cement usage is suggested as one of the solutions for eco-friendly concrete. So this study, Some investigations have been presented for retrofitting and/or strengthening structural elements. Particularly to avoid seismic damage, many researchers have invested seismic resistance material development. Strain-hardening cement composite(SHCC) expects excellent seismic resistance performance. SHCC is one in innovative method that it mixes the fiber of about 2% in the cement composite. To reduce the amount of cement usage, fly ash are widely used as the mineral admixture. Meanwhile, PET fiber made of recycled PET bottle is a type of recycled material, which can be used to construction of database for development and application of Green SHCC.