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Effects of exogenous lactate administration on fat metabolism and glycogen synthesis factors in rats
( Sunghwan Kyun ),( Choongsung Yoo ),( Takeshi Hashimoto ),( Hironori Tomi ),( Noboru Teramoto ),( Jisu Kim ),( Kiwon Lim ) 한국운동영양학회 2020 Physical Activity and Nutrition (Phys Act Nutr) Vol.24 No.2
[Purpose] Lactate has several beneficial roles as an energy resource and in metabolism. However, studies on the effects of oral administration of lactate on fat metabolism and glycogen synthesis are limited. Therefore, the purpose of the present study was to investigate how oral administration of lactate affects fat metabolism and glycogen synthesis factors at specific times (0, 30, 60, 120 min) after intake. [Methods] Male Sprague Dawley (SD) rats (n = 24) were divided into four groups as follows: the control group (0 min) was sacrificed immediately after oral lactate administration; the test groups were administered lactate (2 g/kg) and sacrificed after 30, 60, and 120 min. Skeletal muscle and liver mRNA expression of GLUT4, FAT/CD36, PDH, CS, PC and GYS2 was assessed using reverse transcription-polymerase chain reaction. [Results] GLUT4 and FAT/CD36 expression was significantly increased in skeletal muscle 120 min after lactate administration. PDH expression in skeletal muscle was altered at 30 and 120 min after lactate consumption, but was not significantly different compared to the control. CS, PC and GYS2 expression in liver was increased 60 min after lactate administration. [Conclusion] Our results indicate that exogenous lactate administration increases GLUT4 and FAT/CD36 expression in the muscle as well as glycogen synthase factors (PC, GYS2) in the liver after 60 min. Therefore, lactate supplementation may increase fat utilization as well as induce positive effects on glycogen synthesis in athletes.
유충성,김지수,견성환,Takeshi Hashimoto,Hironori Tomi,임기원 한국운동영양학회 2022 Physical Activity and Nutrition (Phys Act Nutr) Vol.26 No.4
[Purpose] Although several physiological roles of lactate have been revealed in the last decades, its effects on energy metabolism and substrate oxidation remain unknown. Therefore, we investigated the effects of lactate on the energy metabolism of resting rats. [Methods] Male rats were divided into control (Con; distilled water), caffeine (Caf; 10 mg/kg), L-lactate (Lac; 2 g/kg), and lactate-plus-caffeine (Lac+Caf; 2 g/ kg + 10 mg) groups. Following oral administration of supplements, resting energy expenditure (study 1), biochemical blood parameters, and mRNA expression involved in energy metabolism in the soleus muscle were measured at different time points within 120 minutes of administration (study 2). Moreover, glycogen level and Pyruvate dehydrogenase (PDH) activity were measured. [Results] Groups did not differ in total energy expenditure throughout the 6 hour post-treatment evaluation. Within the first 4 hours, the Lac and Lac+Caf groups showed higher fat oxidation rates than the Con group (p<0.05). Lactate treatment decreased blood free fatty acid levels (p<0.05) and increased the mRNA expression of fatty acid translocase (FAT/CD36) (p<0.05) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) (p<0.05) in the skeletal muscle. Hepatic glycogen level in the Lac+Caf group was significantly increased (p<0.05). Moreover, after 30 and 120 minutes, PDH activity was significantly higher in lactate-supplemented groups compared to Con group (p<0.05). [Conclusion] Our findings showed that Lac+Caf enhanced fat metabolism in the whole body and skeletal muscle while increasing hepatic glycogen concentration and PDH activity. This indicates Lac+Caf can be used as a potential post-workout supplement.
HCA 섭취가 지구성 운동시 호흡가스대사에 미치는 영향
이기철(Ki Chul Lee),이수천(Soo Chun Lee),류승필(Sung Pil Ryu),김기훈(Ki Hoon Kim),권태동(Tae Dong Kwon),서혜정(Hye Jung Suh),이강우(Kang Woo Lee),오시이야스유끼(Yasuyuki Oishi),토미히로노미(Hironori Tomi),이실관(Sil Kwan Lee),임기원(Ki Won 한국운동영양학회 2001 Physical Activity and Nutrition (Phys Act Nutr) Vol.5 No.1
N/A To purpose of this study was to examine the effect of (-)-hydroxycitrate (HCA) ingestion on expired gas metabolism during endurance exercise as an ergogenic aid. For the propose, six college soccer players participated and were individually asked to take the different amount of HCA(250㎎, 7550㎎, and placebo) for five days. One hour after ingestion of the HCA, expired gas was analyzed at rest and during endurance exercise. The major findings were as follows; 1. The change of VO2 was not significantly different among the three trials; 2. The HCA trials were slightly less RER than the control trial but it was not significantly different; 3. The HCA trials were less in CHO oxidation than the control trial but it was not significantly different; 4. The HCA trials showed slightly higher fat oxidation than the control trial but it was not significantly different; 5. The exercise time to exhaustion was 66.02min for the control trial, 69.43min for the 250㎎ HCA trial, and 70.94min for the 750㎎ HCA trial. In summary, different amount of HCA ingestion for five days was not statistically affected on expired gas metabolism. As shown in RER and fat oxidation, however, it was slightly lower or higher during exercise at 60% VO2max and 80% VO2max exercise compared to control trial. Therefore, HCA ingestion 1h prior to exercise have the effect of ergogenic aid during endurance exercise in athletes.