http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sarcopenia affects conservative treatment of osteoporotic vertebral fracture
Hiroki Iida,Yoshihito Sakai,Tsuyoshi Watanabe,Hiroki Matsui,Marie Takemura,Yasumoto Matsui,Yasumoto Matsui,Tetsuro Hida,Kenyu Ito,Sadayuki Ito 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.3
Objectives: Sarcopenia and osteoporosis affects activities of daily living and quality of elderly people. However, little is known about its impact on elderly locomotor diseases, such as osteoporotic vertebral fracture (OVF). There is no report investigating the influence of both sarcopenia and osteoporosis on outcomes of OVF. This study aimed to evaluate the clinical outcomes of OVF in elderly patients from sarcopenic perspectives. Methods: This prospective study was conducted with 396 patients, aged 65 years or more, hospitalized for the treatment of OVF (mean age, 81.9 ± 7.1 years; 111 males, 285 females). The primary outcome was the Japanese Orthopaedic Association (JOA) score for lumbar disease (at first visit, hospital discharge, and 1 year after treatment) and Barthel index (at the same time and before hospitalization). The second outcome was living place after discharge. Susceptibility to sarcopenia and osteoporosis were evaluated and clinical results of conservative treatment were compared. Results: Sarcopenia significantly affected Barthel index at first visit and discharge. Sarcopenia patients had significantly higher rate for discharge to nursing home and living in nursing home after 1 year than patients without sarcopenia. Osteoporosis significantly affected the JOA score at the first visit and the Barthel index before hospitalization, at the first visit, discharge, and after 1 year. Osteoporosis did not affect the living place at discharge and after 1 year. Conclusions: Sarcopenia and osteoporosis affected outcomes of conservative treatment for OVF; moreover, sarcopenia affected the living place of OVF patients at discharge and after 1 year
Toru Sakai,Masaru Hashimoto,Tomoki Houda,Rito Furuchi,Hiroki Nakano,Kiyomi Okamoto,Kouichi Okunishi 한국물리학회 2023 새물리 Vol.73 No.12
The magnetization process of the S = 1=2 ferromagnetic and antiferromagnetic bond-alternating chain with competing anisotropies is investigated using the numerical diagonalization of finite-size systems. It is found that when the easy-plane and easy-axis anisotropies are introduced at the ferromagnetic and antiferromagnetic bonds, respectively, the system possibly exhibits the 1/2 magnetization plateau with the spontaneous translational symmetry breaking. The phase diagrams with respect to the two anisotropies are presented.
Sarcopenia in elderly patients with chronic low back pain
Yoshihito Sakai,Hiroki Matsui,Sadayuki Ito,Tetsuro Hida,Kenyu Ito,Hiroyuki Koshimizu,Atsushi Harada 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.4
Objectives: The prevalence of chronic low back pain (CLBP) increases with age and several mechanisms are involved in the development of CLBP, including osteoporosis; however, no associations with sarcopenia have yet been identified. Methods: In total, 100 patients with CLBP and 560 patients without CLBP (nCLBP) aged over 65 years were studied. Skeletal muscle mass index (SMI) and percentage of body fat were evaluated using wholebody dual-energy X-ray absorptiometry. Sarcopenia was diagnosed when the relative SMI was more than 2 standard deviations below the mean in young adults. Thus, the cutoff value for sarcopenia was defined according to Sanada's Japanese population data. Paraspinal muscle cross-sectional areas of the lumbar multifidus and the erector spinae muscles were calculated using magnetic resonance imaging. Results: Forty patients (40.0%) from the CLBP group and 149 (26.6%) from the nCLBP group met the criteria of sarcopenia. SMI was significantly lower and the body fat ratio was significantly higher in the CLBP group compared with the nCLBP group. Sarcopenic obesity was significantly observed in the CLBP group. Lumbar multifidus and the erector spinae muscle cross sectional area were significantly lower in the CLBP group. Conclusions: Elderly patients with CLBP have significantly lower skeletal muscle mass, and age-related mechanisms in sarcopenia are considered to be associated with chronic pain. Therapeutic procedures that are used to treat elderly aging muscle, including muscle strengthening and performance training, can possibly be a treatment for or used to prevent elderly CLBP. © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Novel Field-induced Quantum Phase Transition of the Kagome-lattice Antiferromagnet
Tˆoru Sakai,Hiroki Nakano 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The magnetization process of the S = 1/2 kagome-lattice quantum antiferromagnet is investigatedusing the numerical exact diagonalization up to 36-site clusters. Our previous finite-size scalinganalysis with rhombic clusters indicated the “magnetization ramp” as a novel field-induced quantumphase transition at 1/3 the saturation magnetization. As another possible exotic behavior, we focuson the feature of the magnetization curve at 2/3 the saturation. The critical exponent analysisindicates that a different singular behavior occurs at the 2/3 magnetization.
Dau, Pham Thi,Sakai, Hiroki,Hirano, Masashi,Ishibashi, Hiroshi,Tanaka, Yuki,Kameda, Kenji,Fujino, Takahiro,Kim, Eun-Young,Iwata, Hisato Academic Press 2013 Toxicological sciences Vol.131 No.1
<P>The constitutive androstane receptor (CAR) not only displays a high basal transcriptional activity but also acts as a ligand-dependent transcriptional factor. It is known that CAR exhibits different ligand profiles across species. However, the mechanisms underlying CAR activation by chemicals and the species-specific responses are not fully understood. The objectives of this study are to establish a high-throughput tool to screen CAR ligands and to clarify how CAR proteins from the Baikal seal (bsCAR) and the mouse (mCAR) interact with chemicals and steroid receptor coactivator 1 (SRC1). We developed the surface plasmon resonance (SPR) system to assess quantitatively the interaction of CAR with potential ligands and SRC1. The ligand-binding domain (LBD) of bsCAR and mCAR was synthesized in a wheat germ cell-free system. The purified CAR LBD was then immobilized on the sensor chip for the SPR assay, and the kinetics of direct interaction of CARs with ligand candidates was measured. Androstanol and androstenol, estrone, 17β-estradiol, TCPOBOP, and CITCO showed compound-specific but similar affinities for both CARs. The CAR-SRC1 interaction was ligand dependent but exhibited a different ligand profile between the seal and the mouse. The results of SRC1 interaction assay accounted for those of our previous in vitro CAR-mediated transactivation assay. In silico analyses also supported the results of CAR-SRC1 interaction; there is little structural difference in the ligand-binding pocket of bsCAR and mCAR, but there is a distinct discrimination in the helix 11 and 12 of these receptors, suggesting that the interaction of ligand-bound CAR and SRC1 is critical for determining species-specific and ligand-dependent transactivation over the basal activity. The SPR assays demonstrated a potential as a high-throughput screening tool of CAR ligands.</P>