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A Longitudinal Study of BDNF Promoter Methylation and Depression in Breast Cancer
HeeJu Kang,JaeMin Kim,SeonYoung Kim,SungWan Kim,IlSeon Shin,HyeRan Kim,MinHo Park,MyungGeun Shin,JungHan Yoon,JinSang Yoon 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.4
Objective-Brain-derived neurotrophic factor (BDNF) is investigated in depression related to medical disorders and its secretion is influenced by epigenetic factors. We investigated the association between BDNF promoter methylation and depression following mastectomy for breast cancer. Methods-In total, 309 patients with breast cancer were evaluated 1 week after mastectomy, and 244 (79%) were followed up 1 year later. Depression was diagnosed (major or minor depressive disorder) according to DSM-IV criteria and depression severity was estimated by Montgomery-Asberg Depression Rating Scale (MADRS). We assessed BDNF promoter methylation using leukocyte DNA. The effects of BDNF methylation on depression diagnosis and severity were investigated using multivariate logistic and linear regression models, respectively. The two-way interaction between BDNF methylation and the val66met polymorphism on depression was also evaluated using multivariate logistic regression models. Results-Higher BDNF methylation was independently associated with depression diagnosis and with more severe symptoms at both 1 week and 1 year after mastectomy. No significant methylation-genotype interactions were found. Conclusion-A role for BDNF in depression related to breast cancer was supported. Indeed, the association between depression and BDNF methylation may be useful for identifying patients who are at high risk for depression and for suggesting directions for promising drug research.
HeeJu Kang,KyungYeol Bae,SungWan Kim,HeeYoung Shin,IlSeon Shin,JinSang Yoon,JaeMin Kim 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3
Objective-This study aimed to investigate the longitudinal effects of anxiety, depression, and their comorbidity on physical disorders and disability in an elderly Korean population. Methods-In total, 1,204 community-dwelling elders were evaluated at baseline, and of these 909 (75%) were re-assessed two years later. Anxiety and depression were identified at baseline using questions from the community version of the Geriatric Mental State diagnostic schedule (GMS-B3). Participants were assessed for functional disability and for 11 physical disorders both at baseline and at follow-up. Results-Anxiety alone was associated with the incidence of heart disease, depression alone with the incidence of asthma, and comorbid anxiety and depression with incidence of eyesight problem, persistent cough, asthma, hypertension, heart disease, and gastrointestinal problems. Comorbid anxiety and depression were associated with an increase in the number of physical disorders and the degree of disability during the two-year follow-up, compared to anxiety or depression alone or the absence of anxiety or depression. Conclusion-Anxiety, depression, and particularly their comorbidity should be assessed in the elderly population considering their longitudinal effects on physical disorders and disability. Future study is required to determine whether interventions aimed at these disorders can mitigate their impacts.
HeeJu Kang,KyungYeol Bae,SungWan Kim,IlSeon Shin,YoungJoon Hong,Youngkeun Ahn,MyungHo Jeong,SungWoo Park,YoungHoon Kim,JinSang Yoon,JaeMin Kim 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
Genes related to serotonin are associated with responses to treatment for depression. We examined associations between the serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes and responses to treatment for depressive disorders in acute coronary syndrome (ACS). A total of 255 patients who met the DSM-IV major or minor depressive disorder and recently developed ACS were randomly assigned to the escitalopram (n=127) or placebo (n=128) group in this 24-week double-blind trial (ClinicalTrial.gov identifier: NCT00419471). Remission was defined as a Hamilton Rating Scale for Depression (HAMD) score ≤7. Assays were performed for the 5-HTTLPR, STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G genotypes. Escitalopram was superior to placebo for treating depressive disorder with ACS but there were no significant associations between serotonergic genes and treatment responses even when considering ACS severity. The effect of escitalopram was independent of 5-HTT and 5-HTR2a polymorphisms.
A Scenario-based Exposure Assessment on Polybrominated Diphyenyl Ethers (PBDEs)
Seulki Lee,Heeju Choi,Yongmu Kim,Da-In Kim,Haejung Yoon,Yun-Sook Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
PBDEs are one of the flame retardants widely used in consumer products like plastics, textile, wire cable, electrical and electronic equipments. PBDEs are non-biodegradable, long distance movable, liphophilic substances wiith strong toxicity; these are registered Persistent Organic Pollutants at the Stockholm Convention. Since PBDEs detection in human was reported, there are some studies found that PBDEs in dust, air and even in food have been detected recently. In this study, we have assessed the exposure of PBDEs in Korean population. First, we identify exposure media and routes to make exposure scenario. To determine exposure parameter, we collected monitoring data in various media and selected data which are acceptable for criteria for data appropriateness. For other exposure paramenter, guidances in Korea were given priority, and if not available, foreign data were taken. Later on, we will identify a correlation between the estrimated exposure and human biomonitoring-based exposure and conclude whether the Korean are safe from PBDEs.
A study on the determination of a Health based Guidance Value of Formaldehyde
Hyeonji Oh,Heeju Choi,Yongmu Kim,Seo Yun Kim,Jae-Hong Park,Haejung Yoon,Yun-Sook Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Formaldehyde can be exposed through various routes, including the environment such as air and water, food and cosmetics. Therefore, a risk assessment is necessary to identifiy and manage human health effect. This study aims to identify the relationship between formaldehyde exposure and adverse effects as a hazard characterization step in the risk assessment process and to establish and propose a Health based Guidance Value. In order to carry out ther research, we used some online databases to find scientific papers, reports and opinions published by other institutions. Data for dose-response assessment were selected and classified, as properties of toxicity, and then the most appropriate study for establishing Health based Guidance Value was finally decided. Til et al (1989), 2-years carcinogenicity study with rats, was the optimal toxicity data. As the toxicity endpoint, the Health based Guidance Value TDI 0.15 mg/kg bw/day was proposed by applying an uncertainty factor of 100(interspecies difference 10, intraspeices difference 10) to NOAEL 15 mg/kg bw/day for chronic atrophic gastritis, focal ulceration and glandular hyperplasia in the landular forestomach.
Jae Seung Kang,Taesung Park,Youngmin Han,Seungyeon Lee,Heeju Lim,Hyeongseok Kim,Se Hyung Kim,Wooil Kwon,Sun-Whe Kim,Jin-Young Jang 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.2
Purpose: The 2017 international consensus guidelines (ICG) for intraductal papillary mucinous neoplasm (IPMN) of the pancreas were recently released. Important changes included the addition of worrisome features such as elevated serum CA 19-9 and rapid cyst growth (>5 mm over 2 years). We aimed to clinically validate the 2017 ICG and compare the diagnostic performance between the 2017 and 2012 ICG. Methods: This was a retrospective cohort study. During January 2000–January 2017, patients who underwent complete surgical resection and had pathologic confirmation of branch-duct or mixed-type IPMN were included. To evaluate diagnostic performance, the areas under the receiver operating curves (AUCs) were evaluated. Results: A total of 448 patients were included. The presence of mural nodule (hazard ratio [HR], 9.12; 95% confidence interval [CI], 4.60–18.09; P = 0.001), main pancreatic duct dilatation (>5 mm) (HR, 5.32; 95% CI, 2.67–10.60; P = 0.001), thickened cystic wall (HR, 3.40; 95% CI, 1.51–7.63; P = 0.003), and elevated CA 19-9 level (>37 unit/mL) (HR, 5.25; 95% CI, 2.05–13.42; P = 0.001) were significantly associated with malignant IPMN. Malignant lesions showed a cyst growth rate >5 mm over 2 years more frequently than benign lesions (60.9% vs . 29.7%, P = 0.012). The AUC was higher for the 2017 ICG than the 2012 ICG (0.784 vs . 0.746). Conclusion: The new 2017 ICG for IPMN is clinically valid, with a superior diagnostic performance to the 2012 ICG. The inclusion of elevated serum CA 19-9 level and cyst growth rate to the 2017 ICG is appropriate