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1
Efficient Verifiable Top-k Queries in Two-tiered Wireless Sensor Networks

( Hua Dai ),( Geng Yang ),( Haiping Huang ),( Fu Xiao ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.6
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  ScienceON
  
  KISS
Tiered wireless sensor network is a network model of flexibility and robustness, which consists of the traditional resource-limited sensor nodes and the resource-abundant storage nodes. In such architecture, collected data from the sensor nodes are periodically submitted to the nearby storage nodes for archive purpose. When a query is requested, storage nodes also process the query and return qualified data as the result to the base station. The role of the storage nodes leads to an attack prone situation and leaves them more vulnerable in a hostile environment. If any of them is compromised, fake data may be injected into and/or qualified data may be discarded. And the base station would receive incorrect answers incurring malfunction to applications. In this paper, an efficient verifiable top-k query processing scheme called EVTQ is proposed, which is capable of verifying the authentication and completeness of the results. Collected data items with the embedded information of ordering and adjacent relationship through a hashed message authentication coding function, which serves as a validation code, are submitted from the sensor nodes to the storage nodes. Any injected or incomplete data in the returned result from a corresponded storage node is detected by the validation code at the base station. For saving communication cost, two optimized solutions that fuse and compress validation codes are presented. Experiments on communication cost show the proposed method is more efficiency than previous works.
2
Adsorption of Villin Headpiece onto Graphene, Carbon Nanotube, and C60: Effect of Contacting Surface Curvatures on Binding Affinity

Zuo, Guanghong,Zhou, Xin,Huang, Qing,Fang, Haiping,Zhou, Ruhong American Chemical Society 2011 The Journal of Physical Chemistry Part C Vol.115 No.47
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The adsorption of protein villin headpiece (HP35) onto a graphene has been investigated using large scale molecular dynamics simulations, and the results are compared with similar adsorptions onto a single-wall carbon nanotube and a fullerene, C60. It is found that HP35 loses most of its native secondary and tertiary structures after the adsorption onto graphene. The π–π stacking interactions between the graphene and HP35’s aromatic residues play a key role in this adsorption. The graphene’s softness also helps the binding by adapting its own shape to fit better with aromatic residues in forming stronger π–π stacking interactions. Interestingly, the mechanism of HP35 adsorption onto the other two graphitic nanomaterials is found to be somewhat different, in which the π–π stacking interactions play a lesser role than the dispersion interactions between the nanomaterial and HP35’s aliphatic side chains. These findings indicate that in addition to the chemical composition, the shape of the nanoparticle is also an important factor in determining its interaction with proteins: the contacting surface curvature can lead to different adsorption mechanisms.Graphic Abstract <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2011/jpccck.2011.115.issue-47/jp208967t/production/images/medium/jp-2011-08967t_0004.gif'><A href='http://pubs.acs.org/doi/suppl/10.1021/jp208967t'>ACS Electronic Supporting Info</A>
3
Safety of gadobutrol in over 23,000 patients: the GARDIAN study, a global multicentre, prospective, non-interventional study

Prince, Martin R.,Lee, Hae Giu,Lee, Chang-Hee,Youn, Sung Won,Lee, In Ho,Yoon, Woong,Yang, Benqiang,Wang, Haiping,Wang, Jin,Shih, Tiffany Ting-fang,Huang, Guo-Shu,Lirng, Jiing-Feng,Palkowitsch, Petra Springer Berlin Heidelberg 2017 EUROPEAN RADIOLOGY Vol.27 No.1
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ObjectivesTo investigate the safety and tolerability of gadobutrol at the recommended dose in patients requiring contrast-enhanced magnetic resonance imaging/angiography (MRI/MRA) in the routine setting.MethodsGARDIAN prospectively enrolled 23,708 patients undergoing routine gadobutrol-enhanced MRI/MRA for approved indications at 272 study centres in Europe, Asia, North America, and Africa and monitored for adverse events.ResultsMedian gadobutrol dose was 0.11 mmol/kg body weight. The overall incidence of adverse drug reactions (ADRs) was 0.7 % (n = 170 patients), with similar incidences in patients with renal impairment or cardiac disease, from different geographic regions and in different gadobutrol dose groups. Patients at risk for contrast media reaction had an ADR incidence of 2.5 %. Five patients (0.02 %) experienced serious adverse events, four were drug-related. One patient experienced a fatal anaphylactoid shock, assessed to be related to injection of gadobutrol. The contrast quality of gadobutrol-enhanced images was rated by treating physicians as good or excellent in 97 % cases, with similar ratings in all patient subgroups and indications.ConclusionsThe GARDIAN study shows that gadobutrol at the recommended dose is well tolerated across a large, diverse patient population.Key points• Gadobutrol at recommended dose shows low rates of adverse drug reactions• Gadobutrol demonstrates a uniform safety profile across diverse patient groups• Gadobutrol provides excellent contrast quality in routine practice