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Baskar Gurunathan,Renganathan Sahadevan 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1
The sequential optimization strategy for design of an experimental and artificial neural network (ANN)linked genetic algorithm (GA) were applied to evaluate and optimize media component for L-asparaginase production by Aspergillus terreus MTCC 1782 in submerged fermentation. The significant media components identified by Plackett-Burman design (PBD) were fitted into a second order polynomial model (R^2 = 0.910) and optimized for maximum L-asparaginase production using a five-level central composite design (CCD). A nonlinear model describing the effect of variables on L-asparaginase production was developed (R^2 = 0.995) and optimized by a back propagation NN linked GA. Ground nut oil cake (GNOC)flour 3.99% (w/v), sodium nitrate (NaNO_3) 1.04%, Lasparagine 1.84%, and sucrose 0.64% were found to be the optimum concentration with a maximum predicted Lasparaginase activity of 36.64 IU/mL using a back propagation NN linked GA. The experimental activity of 36.97IU/mL obtained using the optimum concentration of media components is close to the predicted L-asparaginase activity of the ANN linked GA.
( Gurunathan Baskar ),( Renganathan Sahadevan ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.7
Optimization of culture conditions for L-asparaginase production by submerged fermentation of Aspergillus terreus MTCC 1782 was studied using a 3-level central composite design of response surface methodology and artificial neural network linked genetic algorithm. The artificial neural network linked genetic algorithm was found to be more efficient than response surface methodology. The experimental L-asparaginase activity of 43.29 IU/ml was obtained at the optimum culture conditions of temperature 35oC, initial pH 6.3, inoculum size 1% (v/v), agitation rate 140 rpm, and incubation time 58.5 h of the artificial neural network linked genetic algorithm, which was close to the predicted activity of 44.38 IU/ml. Characteristics of L-asparaginase production by A. terreus MTCC 1782 were studied in a 3 L bench-scale bioreactor.