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Life Science : Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction
( Karla L Malloy ),( Hyuk Jae Choi ),( Catherine Fiorilla ),( Fred A Valeriote ),( Teatulohi Matainaho ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yieldedhoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine residue. Hoiamide D displayed inhibitory activity against p53/MDM2 interaction (EC(50)=4.5 μM), an attractive target for anticancer drug development.