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김세권,최진삼,이창국,변희국,전유진,이응호,박인용 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-
참치 뼈에서 추출한 hydroxyapatite를 출발물질로 여러 가지 세라믹 복합체를 제조하여 인공체액에서의 hydroxyapatite 복합체간의 화학결합을 조사하였다. hydroxyapatite 복합체들은 인공체액에서 4주 후부터 화학 결합성질을 나타내었다. 결합강도는 bioglass가 가장 강하게 나타났으며, 조성에 따른 의존성은 관찰할 수 없었다. 인공체액에서 복합체들은 이들의 경계면에서 불균일 핵생성 및 성장에 의해 화학적 결합으로 이루어졌다. Chemical bonding was investigated in the simulated body fluid of several selected hydroxyapatite-containing composites. The hydroxyapatite-containing composites chemically bonded with each other in the simulated body fluid after 4 weeks. Bioglass was strongly bonded in the simulated body fluid, but bonding strength was not depended on composition. Their composite bodies were chemically bonded by heterogeneous nucleation and growth at the interfaces of the specimens in the simulated body fluid.
Kim, Eung Kook,You, Seung Jin,Lee, Jai Hak,Cho, Won Il CATHOLIC MEDICAL CENTER 1992 Bulletin of the Clinical Research Institute Vol.20 No.2
The activation of cellular oncogenes in tumorigenesis can occur by two general mochanisms: by a mutation in the DNA that results in a functionally altered protein, or by deregulation resulting in overespression of the normal cellular product. The latter can occur through a variety of mechanisms such as insertion of strong promoter elements, chromosomal translocation, or gene amplification. In colorectal carcinoma, elevated expression of c-myc and point mutation of c-K-ras has been reported. Authors performed enzyme immunoassay using recently introduced digoxigenin labeled deoxyuridine-triphosphate of DNA labeling kit (Boehringer Mannheim, W. Germany) in colon cancer cell line HT29 and sixteen cases of colorectal cancer tissues to elucidate the expression of c-myc oncogene in human colorectal carcinoma and to determine correlation between cellular differentiation, clinical stage and degree of c-myc expression. Additionally authors tried to detect point mutation of c-K-ras oncogene by paired polymerase chain reaction using both normal (primer-N) and spectific point mutated primer (primer-M) simultaneously which is simple and faster than conventional method. The results were as follows; 1. Expression of c-myc oncogene over 10 pg/ml by dot blot analysis in HT29 colon cancer cell line and colorectal cancer patients was 82.4% whereas 50% in normal tissues from cancer patients. 2. Southern blot analysis for c-myc oncogene expression of 14 cancer tissues expressed over 10 pg/ml in dot blot analysis revealed seven cases (50%) of positive expression and four cases (28%) of elevated expression between 6.5~9.4 kb. But no expression was found in 5 normal tissues with same degree of expression in dot blot analysis. 3. Threr was no correlation between cellular differentiation and degree of c-myc expression. But higher expression of c-myc oncogene was noted in more advanced clinical stage of cancer patients. 4. Positive bands of GTT-GAT substituted point mutation of c-K-ras oncogene of codon 12 were detected on agarose gel electrophoresis in four cases (66.7%) out of six colorectal cancer cell and tissue using paired polymerase chain reaction, but no positive band in three normal color tissues. However, to clarify this result, confirmation of 3 cases of primer-N (+)/primer-M (+) bands by probe hybridization should be done. With above result, authors found that expression of c-myc oncogene in colorectal cancer tissue was elevated than normall mucosa from cancer patient by nonradioactive digoxigeninenzyme DNA labeling and detection method. And paired polymerase chain reaction method will be simple, fast and useful method for detection of c-K-ras oncogene point mutation after confirmation of positive bands by probe hybridization.
Kim, Eung Kook,Park, Yang Kun,Koh, Yong Bok,Kang, Rae Seong,Lee, Yong Kak CATHOLIC MEDICAL CENTER 1981 Bulletin of the Clinical Research Institute Vol.9 No.1
In order to investigate the eventual morphologic changes of organs in cases of aortocaval fistula, authors made aortocaval fistula in Korean albino rats. And observed morphological and microscopical changes of kidney, liver and heart. The author found that aortocaval fistula in rats brought about considerable venous congestion in the kidney and the liver, changes consistent with chronic endocarditis and valvulitis in the heart in addition to congestive cardiomegaly.
Effects of Eck Fistula on the Rat
Kim, Eung Kook,Lee, Yong Kak CATHOLIC MEDICAL CENTER 1977 Bulletin of the Clinical Research Institute Vol.5 No.1
Since the time of Eck, a Russian physiologist, who was the first to perform portasystemic shunt in experimental animal, many attempts have been made to apply this shunt for the relief of portal hypertension in the patients with cirrhosis. But increasing evidence has accumulated that portacaval shunts in normal animals may produce deterious effects and several investigators have been interested in the pathophy-siologic changes introduced by this shunt. The effect of Eck fistula has been intensively studied by various test animals. It was known that fatal outcome is usual when Eck fistula is made in the normal animals such as monkey, dog and pig. With the recent advancement of microvascular surgical technique, portacaval anastomosis became to be feasible on the normal animal such as rat. Many authors have reported the effect of Eck fistula in rats and agreed that the diversion of portal blood is not fatal in this small laboratory animal in contrast with the large animals.
Kim, Eung Kook,Song, Young Tack,Cho, Won Il,Chang, Suk Kyun,Lee, Jong Seo,Yoo, Seung Jin,Choo, Sang Yong,Lee, Jai Hak CATHOLIC MEDICAL CENTER 1991 Bulletin of the Clinical Research Institute Vol.19 No.2
The immunosuppressive agent, prednisolone, is believed to inhibit cell replication, not only of lymphocytes which are responsible for allograft rejection, but also of other tissue cells including hepatocytes. The powerful immunosuppressive agent, cyclosporine A (CsA), has been reported to enhance liver cell proliferation. Therefore, the work was undertaken in an attempt to study the effects of combined administration of CsA and prednisolone on liver regeneration after partial hepatectomy in rats. After partial hepatectomy, CsA and prednisolone were administered both or separately. The liver weight restoration, mitotic indices of the liver remnants, DNA synthesis of the liver, and serum levels of total protein, albumin, aminotransferase, total bilirubin, and alkaline phosphatase of the resected group were compared to that of control group and each experimental group. The results were as follows; 1. The regenerative rates of liver in Group Ⅱ increased significantly at 24 hours, 48 hours after hepatectomy compared with those in Group Ⅲ (p<0.05). 2. In the level of ^3H-thymidine uptake into DNA of liver cells, the values of Group Ⅱ and Group Ⅲ were higher than those of Group Ⅰ on the 1st day after operation (p<0.01). But on the 2nd and 3rd day after the operation, the values of Group Ⅲ were lower than that of Group Ⅳ. 3. The mitotic indices of Group Ⅱ were higher than that of Group Ⅲ and Ⅳ at 2nd day after operation and the index of Group Ⅳ increased at the 3rd day after operation, but decreased thereafter to the level that was higher than that of Group Ⅰ. 4. The results of serum biochemical investigations were not statistically significant.
Kim, Hong,Jee, Young Mee,Song, Byung-Cheol,Shin, Jung Woo,Yang, Soo Hyun,Mun, Ho-Suk,Kim, Hyun-Ju,Oh, Eun-Ju,Yoon, Jung-Hwan,Kim, Yoon-Jun,Lee, Hyo-Suk,Hwang, Eung-Soo,Cha, Chang-Yong,Kook, Yoon-Hoh,K S. Karger AG 2006 Intervirology Vol.50 No.1
<P><I>Objectives:</I> Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. <I>Methods:</I> In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). <I>Results:</I> Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the <I>adr</I>, <I>adw</I> and <I>ayr</I> serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. <I>Conclusions:</I> The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist.</P><P>Copyright © 2007 S. Karger AG, Basel</P>