Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

HIV 감염자에 대한 달팽이 엑기스의 혈액면역학적 효과

조영걸,이희정,오원일,강은숙,김은순,김영봉,조양자,조군제 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

A unique sialic-acid-binding lectin from giant African snail Achatina fulica(AF) has a T cell mitogenicity. It was also noted that acetone extracts of AF have a anti-HIV effect in vitro. Thirty HIV-infected individuals(HIV+) were treated with AF extract(40% Chunho extract) for average 5. 5 months. Peripheral blood sampling and questionnaire were done every month after take. There was a significant decrease of WBC from 4 months after take. As a result, lymphocyte counts also decreased(P<0.01). However, there was a significant increase of CD4+T cell percentage from 1 month(P<0.01). The mean increase of CD4+T cell count was significant for first one month(39/pl)(P<0.05). Body weight also increased significantly(P<0.05). Over 90% HIV+ ex-pressed symptomatic improvement and wanted to be treated with AF extract continuously after the end of this study. In one HIV+ treated with AF for 19 months, the increases of CD4+T cell percentage and counts over 11 times after AF extract take were mean 67% and 85%, respectively, compared to baseline value. These data strongly suggest that aqueous AF extract has a immune enhancing effect on HN+.

근관세정 방법에 따른 수산화칼슘 제재의 제거 효율 비교

은재승,박세희,조경모,김진우 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.6

The purposes of this study were to compare the efficacy of irrigation systems by removing a calcium hydroxide (Ca(OH)₂) paste from the apical third of the root canal and the effect of the patency file. Sixty single rooted human teeth were used in this study. The canals were instrumented by a crown-down manner with .04 taper ProFile to ISO #35. Ca(OH)₂ and distilled water were mixed and placed inside the root canals. The teeth were divided into 6 groups according to the root canal irrigation system and the use of patency file as follows: group 1 - conventional method: group 2 - EndoActivator : group 3 - EndoVac; group 4 - conventional method, patency: group 4 - EndoActivator, patency; group 6 - EndoVac, patency. All teeth were irrigated with sodium hypochlorite. After the root canal irrigation, the teeth were split in bucco-lingual aspect. Percentage of the root canal surface coverage with residual Ca(OH)₂ until 3 mm from working length was analyzed using Image Pro Plus ver. 4.0. Statistical analysis was performed using the One-way ANOVA, t-test and Scheffe's post-hoc test. Conventional groups had significantly more Ca(OH)₂ debris than EndoActivator, EndoVac groups. There was no significant difference between EndoActivator, and EndoVac groups. Groups with patency file showed more effective in removing Ca(OH)₂ paste than no patency groups. but. it was no significant difference. This study showed that EndoActivator and EndoVac systems were more effective in removing Ca(OH)₂ paste from the apical third of the root canal than conventional method. 이 실험의 목적은 근관 내에 충전된 수산화칼슘의 제거 시 치근단 1/3에서 기존의 근관세정법과 EndoActivator, EndoVac system의 세정 효율을 비교하고, 근관 세정 중 치근단공 개방 확인의 영향에 대해 평가하고자 함이다. 60개의 단근치를 사용하였고 ISO #35까지 근관성형 후 수산화칼슘을 충전하였다. 근관 세정법과 치근단공 개방 확인 유무에 따라 6개 실험군으로 나누어 세정하였다. 실험 치아를 양분하여 치근단 3 mm에서 근관 면적에 대한 잔존 수산화칼슘 면적의 백분율을 측정하였다. 실험결과 EndoActivator, EndoVac군이 기존의 근관 세정법 군에 비해 유의하게 높은 제거효율을 나타냈으며 (p<0.05), 치근단공 개방 확인 유무에 따른 유의한 차이는 나타나지 않았다. 이 실험 결과에 따르면 기존의 근관세정법으로 효과적인 세정이 불가능했던 근관의 치근단 1/3부위에서 EndoActivator, EndoVac system과 같은 근관 세정법이 효과적인 대안이 될 수 있다는 결론을 얻었다.

재활승마의 효과에 대한 고찰

조경희,김은정,정재민,황보각 대구대학교 특수교육재활과학연구소 2010 再活科學硏究 Vol.28 No.1

이 연구는 승마 운동의 효과에 대한 객관적이고 구체적인 정보를 제공하기 위해 승마운동이 균형, 자세, 골밀도, 근력, 정서에 어떤 영향을 미치는지 알아보았다. 최신 동향을 살펴보기 위해 90년대 이후의 자료만을 선택하여 승마운동, 승마치료, 재활승마 등 재활 승마와 관련된 키워드를 검색하고 승마운동을 통한 효과를 알아보기 위해 균형, 안정성, 골밀도, 근력 등의 연관 검색어를 함께 검색하였다. 그 결과 지속적인 승마운동은 균형 능력 향상을 위해 효과적인 운동이며 대퇴전자부와 대퇴경부의 좌우측, L3,L4의 골밀도를 향상시키고 승마에서만 발달될 수 있는 특수한 부위를 자극한다. 또한 재활승마를 통해 인지적, 사회적인 부분에 대해 눈에 띄는 향상을 기대할 수 있다. The purpose of this study was to provide information which objective and definite effect of horseback riding about balance, posture, bone mass, muscle strength, emotion. To search the newest trend, Studies for this literature review were sought which investigated the effect of HBRT, hippotherpay, therapeutic horseback riding since 1990. These literature searches were also linked to other descriptive terms. For example, balance, posture, bone mass, muscle strength, emotion. Continuos horseback riding therapy is effective exercise to improve balance ability and bone mass of femur trochanter, femur neck, lumbar 3-4. Also, horseback riding can expect to improve recognition and sociality.

재활승마의 효과에 대한 고찰

&#51312;&#44221;&#55148,&#44608;&#51008;&#51221,&#51221;&#51116;&#48124,&#54889;&#48372;&#44033 대구대학교 특수교육재활과학연구소 2010 再活科學硏究 Vol.28 No.1

&#51060; &#50672;&#44396;&#45716; &#49849;&#47560; &#50868;&#46041;&#51032; &#54952;&#44284;&#50640; &#45824;&#54620; &#44061;&#44288;&#51201;&#51060;&#44256; &#44396;&#52404;&#51201;&#51064; &#51221;&#48372;&#47484; &#51228;&#44277;&#54616;&#44592; &#50948;&#54644; &#49849;&#47560;&#50868;&#46041;&#51060; &#44512;&#54805;, &#51088;&#49464;, &#44264;&#48128;&#46020;, &#44540;&#47141;, &#51221;&#49436;&#50640; &#50612;&#46500; &#50689;&#54693;&#51012; &#48120;&#52824;&#45716;&#51648; &#50508;&#50500;&#48372;&#50520;&#45796;. &#52572;&#49888; &#46041;&#54693;&#51012; &#49332;&#54196;&#48372;&#44592; &#50948;&#54644; 90&#45380;&#45824; &#51060;&#54980;&#51032; &#51088;&#47308;&#47564;&#51012; &#49440;&#53469;&#54616;&#50668; &#49849;&#47560;&#50868;&#46041;, &#49849;&#47560;&#52824;&#47308;, &#51116;&#54876;&#49849;&#47560; &#46321; &#51116;&#54876; &#49849;&#47560;&#50752; &#44288;&#47144;&#46108; &#53412;&#50892;&#46300;&#47484; &#44160;&#49353;&#54616;&#44256; &#49849;&#47560;&#50868;&#46041;&#51012; &#53685;&#54620; &#54952;&#44284;&#47484; &#50508;&#50500;&#48372;&#44592; &#50948;&#54644; &#44512;&#54805;, &#50504;&#51221;&#49457;, &#44264;&#48128;&#46020;, &#44540;&#47141; &#46321;&#51032; &#50672;&#44288; &#44160;&#49353;&#50612;&#47484; &#54632;&#44760; &#44160;&#49353;&#54616;&#50688;&#45796;. &#44536; &#44208;&#44284; &#51648;&#49549;&#51201;&#51064; &#49849;&#47560;&#50868;&#46041;&#51008; &#44512;&#54805; &#45733;&#47141; &#54693;&#49345;&#51012; &#50948;&#54644; &#54952;&#44284;&#51201;&#51064; &#50868;&#46041;&#51060;&#47728; &#45824;&#53748;&#51204;&#51088;&#48512;&#50752; &#45824;&#53748;&#44221;&#48512;&#51032; &#51340;&#50864;&#52769;, L3,L4&#51032; &#44264;&#48128;&#46020;&#47484; &#54693;&#49345;&#49884;&#53412;&#44256; &#49849;&#47560;&#50640;&#49436;&#47564; &#48156;&#45804;&#46112; &#49688; &#51080;&#45716; &#53945;&#49688;&#54620; &#48512;&#50948;&#47484; &#51088;&#44537;&#54620;&#45796;. &#46608;&#54620; &#51116;&#54876;&#49849;&#47560;&#47484; &#53685;&#54644; &#51064;&#51648;&#51201;, &#49324;&#54924;&#51201;&#51064; &#48512;&#48516;&#50640; &#45824;&#54644; &#45576;&#50640; &#46916;&#45716; &#54693;&#49345;&#51012; &#44592;&#45824;&#54624; &#49688; &#51080;&#45796;. The purpose of this study was to provide information which objective and definite effect of horseback riding about balance, posture, bone mass, muscle strength, emotion. To search the newest trend, Studies for this literature review were sought which investigated the effect of HBRT, hippotherpay, therapeutic horseback riding since 1990. These literature searches were also linked to other descriptive terms. For example, balance, posture, bone mass, muscle strength, emotion. Continuos horseback riding therapy is effective exercise to improve balance ability and bone mass of femur trochanter, femur neck, lumbar 3-4. Also, horseback riding can expect to improve recognition and sociality.

최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

유아 미디어 리터러시 교육의 실태 및 인식 조사

조은진, 이재은 서울여자대학교 사회과학연구소 2018 사회과학논총 Vol.25 No.-

This study investigated conditions and teachers’ perceptions of the media literacy curriculum in early childhood education. Participants were 116 teachers in kindergartens around the capital area. They responded to a questionnaire developed for the study. Frequency analysis and percentage were computed for data analysis. The result showed that the kindergarten teachers have little acquaintance with the concept of the media literacy education, but they highly recognized the necessity for the education. For the kindergarten teachers, the ability to understand and express media text was not viewed as a major component of media literacy education. The findings were discussed with respect to their implications for educational practice and future research. 본 연구는 유아 미디어 리터러시 교육에 대한 관심이 높아진 시점에서 미디어 리터러시 교 육과정의 운영 실태와 교사의 인식을 알아보고 앞으로의 교육 방향을 모색하는 데 기여하 기 위한 목적으로 수행되었다. 수도권에 위치한 72개 유치원의 만 5세 학급 교사 116명 을 대상으로 설문조사를 실시하였다. 그 결과, 교사들은 유아 미디어 리터러시의 개념은 잘 모르지만 그 필요성에 대해서는 높게 인식하는 것으로 나타났다. 미디어 리터러시 교육과 정의 목표나 내용에 있어서는 유아 미디어 리터러시 교육의 주요 구성요소인 ‘미디어 텍스 트의 이해와 표현’이 다른 구성요소들에 비해 낮게 인식되었다. 본 연구의 결과들에 대해 논의하고 교육적 적용과 후속연구를 위해 제언하였다.

요추간판탈출증의 수술적 치료성적

조재우,이정청,김재은 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.7

저자는 1980년 1월부터 1991년 12월까지 약 12년간 전북대학교 병원 신경외과에서 요추간판탈출증으로 수술을 받았던 환자중 추적조사가 가능했던 818예를 조사하여 보았던 바 다음과 같은 결과를 얻었다. 1) 수술 합병증으로 수술상처부위의 피부봉합지연이 있었던 예가 36예 였으며, 경막외 혈종이 2예, 간판염이 2예, 체액저류가 2예 였으나 위중한 합병증인 복강내 혈관손상이나 신경근 손상은 없었다. 2) 16예에서 1개월 이내 증상이 재발하거나 지속되어 재수술을 시행하였으며 7예에서 탈출된 간판핵 제거가 불충분하였고, 그외 경막외 혈종 2예, 간판염 2예, 체액 저류 2예, 불충분한 facetectomy 1예, 골극의 제거가 안되었던 예가 1예 였으나, 재수술로 전부 호전되어 좋은 결과를 얻었으나 hemodynamic change로 사료되었던 1예에서는 좋지 못한 예후를 보였다. 3) 25예에서는 6개월 이후 증상이 다시 발생되어 재수술을 시행하였는데 완전히 제거되지 못한 간판핵이 다시 탈출된 예가 14예로 가장 많았고 예후는 좋았으며 facet의 비후와 새로운 골극이 형성되었던 예가 각각 1예였으나 역시 예후는 좋았다. 그러나 심한 신경근 유착과 육아조직이 생성되었던 9예중 8예는 좋지 못한 예후를 보였다. 4) 818예의 요추간판탈출증 수술후 781예(95.5%)에서 좋은 결과를 얻었으나 4.5%에서는 좋지 못한 결과를 얻었다. 이상의 결과로 요추간판탈출증 환자에서 수술방법 및 수기와 환자의 선택이 중요하다고 사료되었으며 신경근 유착과 육아 조직의 생성을 억제하기 위한 방법이 강구되어야 할 것으로 사료되었다. The surgical outcome for lumbar discectomy has improved with development of surgical techniques and strict selection of patients. The authors could follow up and analyse 818 cases who underwent surgery due to herniated lumbar disc from Jan. 1980 to Dec. 1991 at Chonbuk National University Hospital. The early operative complications were delayed wound healing(% cases), extradural hematoma(2 cases), discitid2 cases), but there was no injury to nerve root and abdominal vessels. The specially designed paravertebral m d e retractor and nerve root retractor wwe useful in reducing the operative complications Sixteen patients were reoperated due to acute recurrent symptoms(Within one month). More than one-third of these(7/16) were due to missed disc material, and all of them had good results after reoperation. Twenty five patients were reoperated due to late recurrent symptomdmore than 6 months later). In almost two-third of them(l4/25), rerupture of remained disc material was found Reoperation of these cases had a good result as well. Epidural fibrosis and severe adhesion of nerve mot were showed for reoperation in 9 of the 25 cases. These complications had a poor result except 1 case even after reoperation. The surgical outcome of 818 cases were classified Excellent 618 cases(82%), Good 110 cases(135%), Fair 29 cases(3596) and Poor 8 cases ( 1 % ) . Surgical technique and proper selection of patients were considered as important facter obtaining the better result.

1980년대(1981-1990) 전·후반기 피부과 외래환자의 통계적 비교 관찰

은 철,강승구,권상진,정성재,조지형,권철욱,김영진,김재홍 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

To study the prevalence of common dermatoses 37,638 and 30,286 new outpatients who visited dermatology clinic with Hanyang University Hospital from January 1981 to December 1985 and from January 1986 to December 1990, respectively. Among the 37,638 outpatients in the first 5 years, the total number of male patients were 18,107(48.1%) and female patients were 19,531 (51.9%). Among the 30286 outpatients in the last 5 years, the total number of male patients were 14,705 (48.6%) and female patients were 15,581 (51.4%). In the both periods, the most frequent age groups was 21-30 (27.3%,25.2% respectively). The 15 common dermatoses, bacterial infection, seborreic dermatitis, drug eruption, verruca, syphilis, psoriasis, herpes zoster, and hypopigmentary disorder, in order of frequency. In thelast 5years, dermatophytosis, contact dermatitis, urticaria, acne, other eczema, atopic dermatitis, seborrheic dermatitis, bacterial infection, drug eruption, verruca, gerpes zoster, psoriasis, hypopigmentary disorder, scabies and syphilis were the 15 common dermatoses, as frequency. In both periods, the dermatosis which showed annually increasing tendency was dermatophytosis and those of decreasing tendency was bacterial infection. In the both periods, dermatophytosis, urticaria, bacterial infection, seborrheic dermatitis, verruca, and hypopigmentary disorder occurred most frequently during the summer season, and the incidence of other ecxema, scabies, atopic dermatitis, and herpes zoster increased during the winter season.

하악관에 관한 방사선학적 연구

조성은,김재덕 大韓口腔顎顔面 放射線學會 1991 Imaging Science in Dentistry Vol.21 No.2

The purpose of this study is to improve the availabilities of radiographic technics as diagnostic method related to mandibular canal in dental clinic. For this study 12 dry mandibles were used and 12 orthopantomograms were taken for measuring the gonial angle and the angle of mandibular canal to inferior border of mandible. 12 sites located between the 1st premolar to the 3rd molar region of 3 dry mandibles were selected randomly, for measuring the vertical image magnification rates on three films; intraoral film, orthopantomogram, and computed tomogram, respectively and the thickness of cortical bone, and for observing bucco-lingually and supero-inferiorly location of the mandibular canal. The acquired results were as follows: 1. The mean of the gonial angle and the angle of mandibular canal to inferior border of mandible were 123.9°and 143.5°. And the two angles of dry mandible in alveolar crest stage were greater than in alveolar socket stage. 2. The vertical image length on intraoral film by paralleling technic was magnified by 3.07% on the average, the length on orthopantomogram by 18.49%, and the length on computed tomogram by 0.27%. 3. Observation of the bucco-lingually positional relationship of the mandibular canal was impossible by occlusal projection with the cross section technic and intoral standard projection with the Clack's rule, however, possible by computed tomogram. 4. The thickness of the cortical bone of mandible was thickest in inferior border, and thicker by 6.59% at buccal side than at lingual side.