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RISS 인기검색어
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- 저자 : ( Edwin Kepner Silverman ) (검색결과 1 건)
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COPD Exacerbation according to Chronic Bronchitis and Body Mass Index: Findings from KOCOSS cohort
( Sun Hye Shin ),( Sung Ok Kwon ),( Edwin Kepner Silverman ),( Chin Kook Rhee ),( Kwang Ha Yoo ),( Woo Jin Kim ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Backgrounds and Aims: Chronic bronchitis (CB) is associated with increased risk of exacerbation of chronic obstructive pulmonary disease (COPD). However, distribution of body mass index (BMI) among CB patients has not been fully studied. This study aimed to delineate the BMI distribution of COPD patients according to CB phenotype. We further investigated the impact of BMI on COPD exacerbation according to CB phenotype. Methods: The Korean COPD Subgroup Study (KOCOSS) is prospective, multi-center observational cohort of COPD patients. CB was defined as the presence of both cough and sputum using St. George’s Respiratory Questionnaire (SGRQ) at baseline. BMI was dichotomized into high (≥ 25 kg/ ㎡) or low (< 25 kg/㎡). Exacerbations were compared among four groups: CB-/high BMI, CB-/low BMI, CB+/high BMI, and CB+/low BMI. Potential confounders including baseline lung function, number of comorbidities, inhaled corticosteroid use, and exacerbation in the previous year were adjusted in the analysis. Results: Of 1,264 patients, 18.2%, 46.1%, 7.8%, and 27.9% were CB-/high BMI, CB-/low BMI, CB+/high BMI, and CB+/low BMI group, respectively. During a 1-year follow- up, ≥ 2 moderate or 1 severe exacerbation developed in 15.7%, 29.7%, 27.6%, and 37.1% of CB-/high BMI, CB-/low BMI, CB+/high BMI, and CB+/low BMI group, respectively. Compared with CB-/high BMI group, the other groups had increased risk of exacerbations in fully adjusted model (adjusted IRR [95% CI] 1.91 [1.26 - 2.90], 2.02 [1.15 - 3.56], and 2.23 [1.45 - 3.43] in CB-/low BMI, CB+/high BMI, and CB+/low BMI group, respectively). Conclusions: COPD patients with CB phenotype and BMI < 25 kg/㎡ are common in Korean population. BMI as well as CB phenotype are important risk factors for COPD exacerbation.
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