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( Mi Ran Jo ),( Mi Hee Park ),( Dong Young Choi ),( Dong Yeun Yuk ),( Yuk Mo Lee ),( Jin Moo Lee ),( Jae Hwang Jeong ),( Ki Wan Oh ),( Moon Soon Lee ),( Sang Bae Han ),( Jin Tae Hong ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.3
Amyloid beta (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer`s disease (AD). In this study, we investigated the inhibitory effect of L-theanine, a component of green tea (Camellia sinensis) on Aβ1-42-induced neurotoxicity and oxidative damages of macromolecules. L-theanine inhibited Aβ1-42-induced generation of reactive oxygen species, and activation of extracellular signal-regulated kinase and p38 mitogenic activated protein kinase as well as the activity of nuclear factor kappa- B. L-theanine also significantly reduced oxidative protein and lipid damage, and elevated glutathione level. Consistent with the reduced neurotoxic signals, L-theanine (10-50 μg/ml) concomitantly attenuated Aβ1-42 (5 μM)-induced neurotoxicity in SK-N-MC and SK-N-SH human neuroblastoma cells. These data indicate that L-theanine on Aβ-induced neurotoxicity prevented oxidative damages of neuronal cells, and may be useful in the prevention and treatment of neurodegenerative disease like AD.