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옥찬영 ( Chan Young Oak ),전충환 ( Chung Hwan Jun ),조은애 ( Eun Ae Cho ),이두현 ( Du Hyun Lee ),조성범 ( Sung Bum Cho ),박창환 ( Chang Hwan Park ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),류종선 ( Jong Sun Rew ),최성규 ( 대한소화기학회 2016 대한소화기학회지 Vol.67 No.4
Hemangiomas are the most common benign tumors of the liver. They are generally asymptomatic, but giant hemangiomas can lead to abdominal discomfort, bleeding, or obstructive symptoms. Kasabach-Merritt syndrome is a rare but life-threatening complication of hemangioma, characterized by consumptive coagulopathy with large vascular tumors. More than 80% of Kasabach-Merritt syndrome cases occur within the first year of life. However, there are few reports of Kasabach-Merritt syndrome with giant hepatic hemangioma in adults and, as far as we know, no reports of Kasabach-Merritt syndrome with hepatic hemangioma treated with first line medical treatment only. The most important treatment for this syndrome is removal of the large vascular tumor. However, surgical treatment entails risk of bleeding, and the patient’s condition can mitigate against surgery. We herein present a case of unresectable giant hepatic hemangioma with disseminated intravascular coagulopathy. The patient was a 60-year-old woman who complained of hematochezia, ecchymosis, and abdominal distension. She refused all surgical management and was therefore treated with systemic glucocorticoids and beta-blockers. After two weeks of steroid therapy, she responded partially to the treatment. Her laboratory findings and hematochezia improved. She was discharged on hospital day 33 and observed without signs of bleeding for three months. (Korean J Gastroenterol 2016;67:220-223)
Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer
LEE, WAN-SIK,PARK, YOUNG-LAN,KIM, NURI,OH, HYUNG-HOON,SON, DONG-JUN,KIM, MI-YOUNG,OAK, CHAN-YOUNG,CHUNG, CHO-YUN,PARK, HYUNG-CHUL,KIM, JONG-SUN,MYUNG, DAE-SEONG,CHO, SUNG-BUM,JOO, YOUNG-EUN Spandidos Publications 2015 International journal of oncology Vol.46 No.5
<P>The expression of myeloid cell leukemia-1 (Mcl?1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognostic value of its expression in gastric cancer. PcDNA3.1-Mcl-1 expression and Mcl-1 siRNA vectors were used to overexpress and silence Mcl-1 expression in gastric cancer cell lines including SNU638 and TMK1, respectively. Immunohistochemistry was used to determine the expression of Mcl-1 in gastric cancer tissues. Apoptosis was determined by the TUNEL assay, and cell proliferation was determined by immunostaining with a Ki-67 antibody. Mcl-1 knockdown induced apoptosis through the upregulation of caspase-3, and -7, and PARP activity, and the release of Smac/DIABLO and Omi/HtrA2 into the cytoplasm. Additionally, cell cycle arrest occurred due to decrease of cyclin D1, cell division cycle gene 2 (cdc2), and cyclin-dependent kinase 4 and 6. In contrast, overexpression of Mcl-1 inhibited apoptosis and cell cycle arrest. Mcl-1 knockdown did not suppress tumor cell proliferation in gastric cancer cells, whereas overexpression of Mcl-1 enhanced tumor cell proliferation. The JAK2 and STAT3 signaling cascades were significantly blocked by Mcl-1 knockdown. The mean Ki-67 labeling index (KI) value of Mcl-1 positive tumors was significantly lower than that of Mcl-1 negative tumors. However, there was no significant difference between Mcl-1 expression and the apoptotic index (AI). Mcl-1 expression was significantly increased in gastric cancer tissues compared to normal gastric mucosa tissues, and was associated with age, tumor size, stage, depth of invasion, lymph node metastasis and poor survival. Our study showed that Mcl-1 regulates the cell growth and might be a potential prognostic marker for gastric cancer.</P>
Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells
LEE, WAN-SIK,KIM, NURI,PARK, YOUNG-RAN,OH, HYUNG-HOON,MYUNG, EUN,KIM, SEUNG-HUN,YU, HYUNG-MIN,KIM, MI-YOUNG,OAK, CHAN-YOUNG,CHUNG, CHO-YUN,PARK, HYUNG-CHUL,MYUNG, DAE-SEONG,CHO, SUNG-BUM,JOO, YOUNG-EU Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.2
<P>Epithelial-mesenchymal transition (EMT) is a critical process that occurs during cancer progression, and cancer stem cells have been shown to acquire the EMT phenotype. Myeloid cell leukemia-1 (Mcl-1) has been implicated in cancer progression and is overexpressed in a variety of human cancers. However, the interaction between Mcl-1 and EMT in human gastric cancer (GC) is unclear. We investigated the impact of Mcl-1 expression levels on EMT and the underlying signaling pathways in human GC cells. We used the human GC cell lines, AGS and SNU638, and small interfering RNAs (siRNAs) to evaluate the effects of Mcl-1 knockdown on cell adhesion, migration and invasion. Expression of Mcl-1 and other target genes was determined using reverse transcription-polymerase chain reaction assays and western blotting. The results revealed that expression levels of Mcl-1 mRNA and protein in the AGS and SNU638 cells were reduced following transfection with Mcl-1 siRNAs. Knockdown of Mcl-1 led to increased cellular adhesion to fibronectin and collagen. Expression levels of vimentin, MMP-2, MMP-9 and Snail protein were decreased following knockdown of Mcl-1. However, expression of E-cadherin was increased in the AGS cells following knockdown of Mcl-1. The expression of cancer stemness markers, such as CD44 and CD133, was not altered by knockdown of Mcl-1. Knockdown of Mcl-1 suppressed tumor cell migration and invasion in both human GC cell lines. Signaling cascades, including the β-catenin, MEK1/2, ERK1/2 and p38 pathways, were significantly blocked by knockdown of Mcl-1. Our results indicate that Mcl-1 expression induces EMT via β-catenin, MEK1/2 and MAPK signaling pathways, which subsequently stimulates the invasive and migratory capacity of human GC cells.</P>
Choo Oak-Sung,Kim Hantai,Lee Seung Jae,Kim So Young,Lee Kyu-Yup,Lee Ho Yun,Moon In Seok,Seo Jae-Hyun,Rah Yoon Chan,Song Jae-Jun,Nam Eui-Cheol,Park Shi Nae,Song Jae-Jin,Shim Hyun Joon 대한의학회 2024 Journal of Korean medical science Vol.39 No.5
Background: Tinnitus is a bothersome condition associated with various symptoms. However, the mechanisms of tinnitus are still uncertain, and a standardized assessment of the diagnostic criteria for tinnitus is required. We aimed to reach a consensus on diagnosing tinnitus with professional experts by conducting a Delphi study with systematic review of the literature. Methods: Twenty-six experts in managing tinnitus in Korea were recruited, and a two-round modified Delphi study was performed online. The experts evaluated the level of agreement of potential criteria for tinnitus using a scale of 1–9. After the survey, a consensus meeting was held to establish agreement on the results obtained from the Delphi process. Consensus was defined when over 70% of the participants scored 7–9 (agreement) and fewer than 15% scored 1–3 (disagreement). To analyze the responses of the Delphi survey, the content validity ratio and Kendall’s coefficient of concordance were evaluated. Results: Consensus was reached for 22 of the 38 statements. For the definition of tinnitus, 10 out of 17 statements reached consensus, with three statements achieving complete agreement including; 1) Tinnitus is a conscious perception of an auditory sensation in the absence of a corresponding external stimulus, 2) Tinnitus can affect one’s quality of life, and 3) Tinnitus can be associated with hearing disorders including sensorineural hearing loss, vestibular schwannoma, Meniere’s disease, otosclerosis, and others. For the classification of tinnitus, 11 out of 18 statements reached consensus. The participants highly agreed with statements such as; 1) Vascular origin is expected in pulse-synchronous tinnitus, and 2) Tinnitus can be divided into acute or chronic tinnitus. Among three statements on the diagnostic tests for tinnitus only Statement 3, “There are no reliable biomarkers for sensory or emotional factors of tinnitus.” reached consensus. All participants agreed to perform pure-tone audiometry and tinnitus questionnaires, including the Tinnitus Handicap Inventory and Tinnitus Questionnaire. Conclusion: We used a modified Delphi method to establish a consensus-based definition, a classification, and diagnostic tests for tinnitus. The expert panel reached agreement for several statements, with a high level of consensus. This may provide practical information for clinicians in managing tinnitus.
성현찬 ( Hyun Chan Sung ),황소영 ( So Young Hwang ),채미옥 ( Mie Oak Chae ),박은석 ( Eun Suk Park ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2010 한국환경복원기술학회지 Vol.13 No.6
This study aims at analyzing the development status of surroundings of natural environment conservation areas and securing an adequate distance from development activities to conserve natural environment conservation areas efficiently or developing an improvement plan for setting conservation areas. Findings from the study shows that 1) rather than simply designating a legal natural environment conservation area, a conceptual scope approach of a “core area”, “buffer area”, and “transition area” such as in zoning of a “biosphere reserve” by UNESCO is recommended; 2) when setting an adequate range in a natural environment conservation area, it should be set by fully considering locational situation and the regional and environmental features of surroundings rather than setting a certain distance uniformly; 3) instead of designating wetlands only as a conservation area, entry and exit areas should be also included as buffer areas and in the case of wild animals, not only habitats but also feeding areas should be designated as conservation areas; and 4) an adequate horizontal separation space is important in the case of ground development, but for natural resources related to subterranean water and geological situation such as wetlands, an adequate vertical separation space should be fully considered.
이연숙,오찬옥,윤영선,백혜선,최혜정 연세대학교 대학원 1992 延世論叢 Vol.28 No.1
The purpose of this study is to describe the living characteristics of the three generation family. It is a part of article series toward developing a three generation family apartment as a cultural housing model in Korea. A pilot study was done through interviews with both housewives of the younger generation and the elderly in 56 households. It was done to grasp generally and deeply the research contents for the main questionnaire survey. The main survey was done through a mailing whose respondents were 694 housewives of younger generation. Data were analyzed using the SPSS package. Major findings were as follows : Female elderly was most popular type. Married children tended to live together with the forced feeling of responsibility rather than with volunteering attitude. Many good points steming from three generation living together, however, were recognized by the housewives. This will be a good addition to re-estimate the value of the elderly in this industrial society. The younger generation had power in managing the various aspects in the household. They felt stress and expressed various undesirble behavioral adjustments and constraints in relation to the stress. Several planning concepts including privacy and storage space were suggested to enhance the quality of residential environment for the family.