http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
우리나라 초고층용(超高層用) 건설(建設)팩토리 개발(開發)을 위한 성능평가체계(性能評價體系)에 관(關)한 기초적(基礎的) 연구(硏究)
최원준 ( Won-jun Choi ),김창규 ( Chang-kyu Kim ),송인식 ( In-shick Song ),임상채 ( Sang-chae Lim ) 한국건축시공학회 2007 한국건축시공학회 학술발표대회 논문집 Vol.7 No.2
This study aims to develop a performance evaluation system for the Construction Factory(CF). The CF is a kind of full automation system for building construction which consists of the lifting system for building materials, the built-up unit for steel structural components, the bolting robots, the control center for the site management, and the site covering system. The CF is developing now as a project of the construction automation and robotics. In this study we firstly reviewed the state-of-the-art of the construction automation and robotics in the foreign and the domestic, and investigated the precedent case of the CF such as the SMART System of Shimizu Co., Japan. We believe that without an objective evaluation of the results there won``t be growth in technological R&D. Therefore, this study sees the developing CF as an new technology and method in building construction, and proposes the direction and frame of the appropriate evaluation which can be applied into the CF.
BDNF Enhancement of Neuronal Differentiation with Adipose-Derived Stem Cells(ADSCs)
( Chae Yoon Lim ),( Kwon Il Keun ),( Jeong June Choi ),( Hee Jin Lee ),( Sang Hee Park ),( Weon Sun Lee ),( Dong Hoon Kwak ),( Ji Youl Lee ),( Young Joon Jun ),( Won Bae Lee ),( Sung Eun Kim ),( Dai J 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
Adipose-derived stem cells(ADSCs) are multipotent cells that can be manipulated to differentiate into different cell lines and are considered a potential cell source for regenerative medicine and tissue engineering. The brain derived neurotrophic factor (BDNF) is known to stimulate stem cells to differentiate into neuronal cells as well as promote plasticity. The purpose of this study was to evaluate the effects of BDNF on the neuronal differentiation of ADSCs. The proliferation of the ADSCs was increased by BDNF in a dose-dependent manner. The expression of neuronal markers including Nestin and microtubule-associated protein(MAP2) were highly upregulated by BDNF. In addition, BDNF considerably suppressed the expression of glial fibrillary acidic protein(GFAP), a preventative glial cell or astrocyte marker. Using immunocytochemistry, we confirmed the results by real time-PCR. An increased production of Nestin and MAP2 by BDNF, but not GFAP was observed. These data show that supplementation of the ADSCs with BDNF effectively maintained cell survival, proliferation and differentiation of these cells into neuronal precursor cells. In conclusion, specific neuronal differentiation of ADSCs after treatment with BDNF increased the generation of a mature neuronal phenotype.
Lim Jae-Won,Kim Chan Woo,Park Hyoung Ouk,Chung Eui Yup,Chae Chang Ho,Son Jun Seok,Shin Young Hoo,Park Seung Hyun,Choi Sang Moon 대한직업환경의학회 2023 대한직업환경의학회지 Vol.35 No.1
Background: Shift work has been shown to increase the risk of cardiovascular disease (CVD) based on several evidences. The classic risk factors of CVD include age, hypertension, smoking, obesity and diabetes. Recently, the serum homocysteine level has been reported to be a valuable indicator of CVD risk. This study aimed to determine the variation in serum homocysteine level as a cardiovascular risk indicator among female workers according to shift work. Methods: The data of regular health examination of workers at an electronic manufacturing services company in Yeongnam region, South Korea in 2019 were examined in this study. The investigation was based on a cross-sectional study conducted on 697 female workers (199 day workers and 498 shift workers). The sociodemographic and biochemical characteristics were compared between day workers and shift workers. Through a logistic regression analysis, the odds ratio (OR) of the increased serum homocysteine level in relation to shift work was determined. Results: Compared to female day workers, female shift workers showed significantly higher level of serum homocysteine (8.85 ± 2.16 vs. 9.42 ± 2.04 μmol/mL; p = 0.001). The OR of day workers against shift workers was 1.81 (95% confidence interval [CI]: 1.25–2.63). With the adjustment of variables that may influence the level of serum homocysteine, the adjusted OR was 1.68 (95% CI: 1.09–2.60). Conclusions: The serum homocysteine level was significantly higher in shift workers than in day workers. It is thus likely to be a useful predictor of CVD in shift workers.
( Chae Min Lim ),( Jae Hyun Kim ),( Dong Jae Baek ),( Joo Youn Lee ),( Min Jae Cho ),( Yoon Sook Lee ),( Chang Yuil Kang ),( Doo Hyun Chung ),( Won Jea Cho ),( Sang Hee Kim ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
CDld molecules recognize glycolipid antigens with straight chain fatty acid moieties. Although most of the residues in the COld binding groove are hydrophobic, some of the amino acids can form hydrogen bonds. Consequently, we have designed ai-hydroxy fatty acid-containing glycolipid derivatives of the prototypical COld ligand a-GaiCer. The potency of the ai-hydroxy analogues of the proper length is comparable to that of a-GaiCer. We propose, based on the biological results and molecular modeling studies, that a hydrogen bonding interaction is involved between the w-hydroxy group and a polar amino acid residue in the hydrophobic binding groove.
Lim, Nam-Kyoo,Lee, Sang Eun,Lee, Hae-Young,Cho, Hyun-Jai,Choe, Won-Seok,Kim, Hokon,Choi, Jin Oh,Jeon, Eun-Seok,Kim, Min-Seok,Kim, Jae-Joong,Hwang, Kyung-Kuk,Chae, Shung Chull,Baek, Sang Hong,Kang, Seo Elsevier 2019 Journal of cardiology Vol.73 No.2
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Identifying patients with acute heart failure (HF) at high risk for readmission or death after hospital discharge will enable the optimization of treatment and management. The objective of this study was to develop a risk score for 30-day HF-specific readmission or death in Korea.</P> <P><B>Methods</B></P> <P>We analyzed the data from the Korean Acute Heart Failure (KorAHF) registry to develop a risk score. The model was derived from a multiple logistic regression analysis using a stepwise variable selection method. We also proposed a point-based risk score to predict the risk of 30-day HF-specific readmission or death by simply summing the scores assigned to each risk variable. Model performance was assessed using an area under the receiver operating characteristic curve (AUC), the Hosmer–Lemeshow goodness-of-fit test, the net reclassification improvement (NRI), and the integrated discrimination improvement (IDI) index to evaluate discrimination, calibration, and reclassification, respectively.</P> <P><B>Results</B></P> <P>Data from 4566 patients aged ≥40 years were included in the analysis. Among them, 446 (9.8%) had 30-day HF-specific readmission or death. The final model included 12 independent variables (age, New York Heart Association functional class, clinical history of hypertension, HF admission, chronic obstructive pulmonary disease, etiology of cardiomyopathy, systolic blood pressure, left ventricular ejection fraction, serum sodium, brain natriuretic peptide, N-terminal prohormone of brain natriuretic peptide at discharge, and prescription of β-blockers and angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists at discharge). The point risk score showed moderate discrimination (AUC of 0.710; 95% confidence interval, 0.685–0.735) and good calibration (<I>χ</I> <SUP>2</SUP> =8.540, <I>p</I> =0.3826).</P> <P><B>Conclusions</B></P> <P>The risk score for the prediction of the risk of 30-day HF-specific readmission or death after hospital discharge was developed using 12 predictors. It can be utilized to guide appropriate interventions or care strategies for patients with HF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The risk of 30-day heart failure (HF) readmission or death can be estimated with 12 variables. </LI> <LI> The risk for short-term HF-specific readmission or death can be calculated easily. </LI> <LI> The model has the potential to reduce readmission by identifying high-risk patients. </LI> <LI> The risk model can be utilized to guide suitable interventions or care in patients. </LI> </UL> </P>