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이상우,강호종,안상열,채윤석,윤재길,최경옥 진주산업대학교 농업기술연구소 2007 農業技術硏究所報 Vol.20 No.-
시중에 판매되고 있는 상토는 제조 회사에 따라 재료의 구성 및 혼합 비율이 다르다. 시판용상토를 제조사별로 구입하여 상토 제조사에 따라 배추 육묘기 묘소질에 미치는 영향에 대해 조사하였다. 상토 제조사 별로 배추의 지상부 및 지하부의 생육에 많은 차이가 있었다. 그리고 엽록소 함량 및 단백질 함량에도 차이가 많았으며, 엽록소 및 단백질 함량이 높았던 상토에서 배추의 생육이 좋았다. 상토 제조사별로 상토의 재료 및 혼합비율에 따라 배추의 유묘기 생육에 많은 영향을 미치는 것으로 나타났다. The substrate is very important to grow seedling because of directly effect on seedling quality of Chinese cabbage. The substrates manufactured by the companies consist of different materials and mixing ratios. This study was conducted to observe the seedling quality of Chinese cabbage by using of the kinds of substrate. The number of leaf, leaf area, fresh weight, dry weight, root length, root weight and T/R ratio of the seedling were shown in different from each substrate manufactured by the companies. And chlorophyll and protein content of the seedling were also shown in different from substrates supplied from the companies, respectively. Substrate which was high in that was also higher in seedling quality. The material and mixing ratios of substrate effected on the growth of cabbage
Transduction of artificial transcriptional regulatory proteins into human cells
Yun, Chae-Ok,Shin, Hyun-Chul,Kim, Tae-Dong,Yoon, Wan-Hee,Kang, Yoon-A,Kwon, Heung-Sun,Kim, Seong Keun,Kim, Jin-Soo Oxford University Press 2008 Nucleic acids research Vol.36 No.16
<P>Protein transduction (PT) is a method for delivering proteins into mammalian cells. PT is accomplished by linking a small peptide tag—called a PT domain (PTD)—to a protein of interest, which generates a functional fusion protein that can penetrate efficiently into mammalian cells. In order to study the functions of a transcription factor (TF) of interest, expression plasmids that encode the TF often are transfected into mammalian cells. However, the efficiency of DNA transfection is highly variable among different cell types and is usually very low in primary cells, stem cells and tumor cells. Zinc-finger transcription factors (ZF-TFs) can be tailor-made to target almost any gene in the human genome. However, the extremely low efficiency of DNA transfection into cancer cells, both <I>in vivo</I> and <I>in vitro</I>, limits the utility of ZF-TFs. Here, we report on an artificial ZF-TF that has been fused to a well-characterized PTD from the human immunodeficiency virus-1 (HIV-1) transcriptional activator protein, Tat. This ZF-TF targeted the endogenous promoter of the human <I>VEGF-A</I> gene. The PTD-attached ZF-TF was delivered efficiently into human cells <I>in vitro</I>. In addition, the VEGF-A-specific transcriptional repressor retarded the growth rate of tumor cells in a mouse xenograft experiment.</P>
( Chae Ok Yun ) 대한간학회 2015 춘·추계 학술대회 (KASL) Vol.2015 No.2
A challenge to develop adenovirus (Ad)-mediated therapeutics has been issued to treat metastatic cancer via systemic administration. Systemic administration of conventional naked Ads leads to the acute accumulation of Ad particles in the liver, induction of neutralizing antibody, short blood circulation half-life, nonspecific biodistribution in undesired organs, and low selective accumulation in the target disease site. Versatile strategies involving the modification of viral surfaces with polymers and nanomaterials have been designed to maximize Ad antitumor activity and specificity by systemic administration. Modification of the Ad surface allows Ad to circulate in the bloodstream for a longer time, to be not targeted to the liver, and to passively accumulate in tumor sites via enhanced permeation and retention effects. The addition of affinity tags results in active targeting and high efficacy. Biodistribution, blood circulation time, immune response, and therapeutic efficacy of functionalized oncolytic Ad nanocomplex will be discussed, proposing the future direction of viral/nonviral combinatory delivery for cancer therapy.
Coxsackie and Adenovirus Receptor Binding Ablation Reduces Adenovirus Liver Tropism and Toxicity
Yun, Chae-Ok,Yoon, A-Rum,Yoo, Ji Young,Kim, Hoguen,Kim, Minjung,Ha, Taeyong,Kim, Gwi Eon,Kim, Hyunhee,Kim, Joo-Hang Mary Ann Liebert 2005 Human gene therapy Vol.16 No.2
<P>Human adenovirus-based vectors have emerged as a new promising vehicle for in vivo gene transfer-mediated therapy. However, the full potential of this methodology has not been fully realized because of the nonspecific tissue distribution of adenoviral vectors. Adenovirus infection is initiated by forming a complex between the fiber protein and a ubiquitously expressed host cell membrane protein, coxsackie B virus and adenovirus receptor (CAR). Therefore, ablating the adenovirus vector's ability to bind to the CAR is the first step in redirecting adenoviral tropism. To ablate CAR binding, we mutated the Bbeta sheet of the fiber knob, generating CAR-binding ablated replication-incompetent (dl-K420A-Z) and replication-competent (YKLK420A) adenoviral vectors. The in vitro transduction efficiency of dl-K420A-Z was significantly reduced in comparison to dl-LacZ carrying the wild-type fiber in CAR-positive cells but not in CAR-negative cells, suggesting that the mutation introduced in the Bbeta sheet of the fiber knob could disable the CAR-dependent transduction pathway. The in vivo transduction was also dramatically reduced in the liver and other organs for mice treated with dl-K420A-Z, compared with a cognate control vector, dl-LacZ. Concomitant with this attenuated gene transfer efficiency in vivo was a substantial reduction in the amount of general toxicity observed in the YKL-K420A-treated mice. Diminished toxicity was surmised from quantitative measurement of serum level of enzymes for liver and kidney function, hematologic chemistries, histopathology, and differences in lethality. Significant decrease in serum transaminases (alanine transferase [ALT] and aspartate transferase [AST]) was observed in mice treated with YKL-K420A. In addition, the lethality was lower in the YKLK420A- treated groups compared to the YKL-1-treated groups at all doses examined. Furthermore, the hepatopathologic analysis revealed that YKL-1 induced focal zonal necrosis and hepatocyte degeneration, while YKL-K420A induced mild spotty necrosis. In summary, this decreased vector tropism of CAR-binding ablated adenoviruses in normal tissues may increase the amount of virus available for infecting tumor cells and thus increase the antitumor efficacy with fewer unwanted side effects.</P>
Yun, Jieun,Han, Sang-Bae,Kim, Hong Jun,Go, Se-il,Lee, Won Sup,Bae, Woo Kyun,Cho, Sang-Hee,Song, Eun-Kee,Lee, Ok-Jun,Kim, Hee Kyung,Yang, Yaewon,Kwon, Jihyun,Chae, Hee Bok,Lee, Ki Hyeong,Han, Hye Sook The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.3
Purpose: Peritoneal carcinomatosis in gastric cancer (GC) patients results in extremely poor prognosis. Malignant ascites samples are the most appropriate biological material to use to evaluate biomarkers for peritoneal carcinomatosis. This study identified exosomal MicroRNAs (miRNAs) differently expressed between benign liver cirrhosis-associated ascites (LC-ascites) and malignant gastric cancer-associated ascites (GC-ascites), and validated their role as diagnostic biomarkers for GC-ascites. Materials and Methods: Total RNA was extracted from exosomes isolated from 165 ascites samples (73 LC-ascites and 92 GC-ascites). Initially, microarrays were used to screen the expression levels of 2,006 miRNAs in the discovery cohort (n=22). Subsequently, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analyses were performed to validate the expression levels of selected exosomal miRNAs in the training (n=70) and validation (n=73) cohorts. Furthermore, carcinoembryonic antigen (CEA) levels were determined in ascites samples. Results: The miR-574-3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). The diagnostic performance of CEA for GC-ascites was improved by the combined analysis of miR-181b-5p and CEA (AUC=0.981 and 0.946 for the training and validation cohorts, respectively). Conclusions: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis.
정보보호 : 수중통신에 활용가능한 다양한 플랫폼에서의 암호 알고리즘 성능비교
윤채원 ( Chae Won Yun ),이재훈 ( Jae Hoon Lee ),이옥연 ( Ok Yeon Yi ),신수영 ( Su Young Shin ),박수현 ( Soo Hyun Park ) 한국정보처리학회 2016 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.5 No.3
Recently, The interest about underwater acoustic communication is increase such as marine resources, disaster prevention, weather prediction, and so on. Because the underwater acoustic communication uses a water as media, the underwater acoustic communication has a lot of restrictions. Although the underwater acoustic communication is hard, it is important to consider the security. In this paper, we estimate the performance of cryptographic algorithms(AES, ARIA, and LEA) on a various devices, available in underwater acoustic communication, and analysis the results. This result will be provide effective data confidentiality for underwater communication.