발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

반송용 선형 유도 전동기의 급속 제동특성에 관한 연구

우정인,조윤현,노태균,신동률,이채동 東亞大學校 1996 東亞論叢 Vol.33 No.-

The SLIM used in the conveyance system has been generally developed the controller based on the slip frequency control and the VVVF method to obtain the quirk response for the position control signal. This paper deals with the trust control of the SLIM by vector control with Bang-Bang condition. Also, the control system is composed of the Pl controller for soft start of the SLIM and the q-axis current controller for correction in phase with Space Vector for reducing the harmonic pulsation in low speed. The processing for vector control and robust dynamic breaking control is carried out by MC80196KC micro processor and IGBT module. The proposed scheme is verified through the computer simulation and experiments for the 10KW SLIM.

Static Induction Transistor(SIT), Drive signal phase shift control, Induction heating

노채균,김동희,김종해,남승식,정원영,심광열 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

This paper proposed a novel SIT high frequency resonant inverter having drive signal phase shift control function. Phase control type inverters using SIT can realize a power conversion at the high switching frequency with low switching loss. Especially, the high output power can be obtained by connecting the output terminal of two unit inverters in series. The stability of system using protection circuit for over current and the automatic follow-up control for load variation by using PLL are presented. This inverter produces approximately sinusoidal waveform at a high frequency, ranging from 180 Khz to 220 Khz, and is applied to the 2KW induction heating. The operating characteristics of this inverter circuit are discussed from a theoretical point of view and compared with experimental results.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

택시 운전기사들의 유병상태에 관한 조사 연구

심운택,이종연,오장균,조영채 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

A questionnaire survey was conducted on 572 taxi drivers in Taejeon City to investigate the prevalence rate which was derived from the subjective symptoms of respondents according to the working condition and daily life effected on health. The disease were classified the cardiovascular disease, gastrointestinal disease, neurotic disease and musculoskeletal disease according to the subjetive symptoms. The results obtained were as follows : 1. Among the subjective symptoms. the complaint rate of latigability, eye strain, loss of appetite, irritability, dizziness on standing, stiffness on shoulder. and low back pain became decreased in that order. 2. The prevalence rates of cardiopulmonary and gastrointestinal disease were low in the old aged group, and the prevalence rates of all disease was proportional to the frequencies of accident experience. but no evident trend in job conditions. 3. The groups having regular meal time and rest after meal showed low prevalence rate in all disease. The sleeping time and smoking habit were related to the neurotic and cardiopulmonary disease. 4. The group of usual drug intake occupied 68% of all studied subjects, the age group of 40 or more and the group of having G-1 disease showed high rats of usual drug intake.

ZVS를 이용한 SEPP 고주파 공진 인버터의 특성해석

김동희,노채균,김종해,민병재,배상준 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

Applied the high frequency switching technology to the ower conversion circuits, the turn on and off loss of switch point out practically large the point at issue, in order to reduce switching loss, the switching method using tank resonant circuit be connected serial and parallel with load have been continuously investigated. This paper was described about principle and form of proposed circuit made use of soft switching technology ZVS(Zero Voltage Switching) and ZCS(Zero Current Switching) to reduce turn on and off loss at switching. Also, the analysis of the proposed circuit is described generally by using normalized parameter and basic operating principle and driving characteristics have been evaluated as to switching frequency and load parameter. Based on the charactristics value, a method of circuit design is proposed. In addition, Pspice's simulation and experimental waveforms are compared with theoretical ones. The experimental results shows that the proposed Inverter can be used practically such as power source system for induction cooker etc.

Insulation Design and Reliability Evaluation of ±80kV HVDC XLPE Cables

Chae-Kyun Jung,Hung-Sok Park,Ji-Won Kang 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.3

This paper describes insulation design and its reliability evaluation of ±80kV HVDC XLPE cable. Recently, the construction of HVDC transmission system, which is combined overhead line with underground cable, has been completed. This system is installed with existing 154 kV AC transmission line on the same tower. In this paper, the lightning transient analysis is firstly reviewed for selection of basic impulse insulation level and nominal insulation thickness. Then the electrical performance tests including load cycle test and superimposed impulse test based on CIGRE TB 496 are performed to evaluate the reliability of newly designed HVDC cable. There is no breakdown for ±80kV HVDC XLPE cable during electrical performance test. Finally, this system is installed in Jeju island based on successful electrical performance test (Type test). After installation tests are also successfully completed.

Development of an EMTP-ATP Based Simulator for Sheath Circulating Current Analysis

( Chae Kyun Jung ),( Jong Beom Lee ) 원광대학교 공업기술개발연구소 2007 工業技術開發硏究誌 Vol.27 No.-

A Study on Lightning Surges in Underground Distribution Systems

Chae-Kyun Jung,Sang-Kuk Kim,Jong-Beom Lee 대한전기학회 2005 KIEE International Transactions on Power Engineeri Vol.a5 No.2

Development of Fault Location Algorithm and Its Verification Experiments for HVDC Submarine Cables

Chae-Kyun Jung,Hung-Sok Park,Ji-Won Kang,Xinheng Wang,Yong-Kab Kim,Jong-Beom Lee 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.6

A new fault location algorithm based on stationary wavelet transform and its verification experiment results are described for HVDC submarine cables in this paper. For wavelet based fault location algorithm, firstly, 4th level approximation coefficients decomposed by wavelet transform function are superimposed by correlation, then the distance to the fault point is calculated by time delay between the first incident signal and the second reflected signal. For the verification of this algorithm, the real experiments based on various fault conditions and return types of fault current are performed at HVDC submarine cable test yard located in KEPCO(Korea Electric Power Corporation) Power Testing Center of South Korea. It proves that the fault location method proposed in this paper is very simple but very quick and accurate for HVDC submarine cable fault location.