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- 저자 : ( Carlos Sanz Garcia ) (검색결과 2 건)
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Propagation of Nuclear Data Uncertainties in Transmutation Calculations Using ACAB Code
O. Cabellos,N. Garcia-Herranz,Carlos J. Diez de la Obra,R. Alvarez-Cascos,J. Sanz,F. Ogando,P. Sauvan 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The assessment of the accuracy of parameters related to the reactor core performance (e.g. keff) and fuel cycle (e.g. isotopic evolution/transmutation) due to the uncertainties in the basic nuclear data (ND) is a critical issue. Different error propagation techniques (adjoint/forward sensitivity analysis procedures and/or Monte Carlo technique) can be used to address by computational simulation the systematic propagation of uncertainties on the final parameters. To perform this uncertainty assessment, the ENDF covariance files (variance/correlation in energy and cross-reactions-isotopes correlations) are required.In this paper, we assess the impact of ND uncertainties on the isotopic prediction for a conceptual design of a modular European Facility for Industrial Transmutation (EFIT) for a discharge burnup of 150 GWd/tHM. The complete set of uncertainty data for cross sections (EAF2007/UN, SCALE6.0/COVA-44G), radioactive decay and fission yield data (JEFF-3.1.1) are processed and used in ACAB code.
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Adiponectin as an Anti-fibrotic and Anti-inflammatory Adipokine in the Liver
( Pil Hoon Park ),( Carlos Sanz Garcia ),( Laura E Nagy ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Hepatic fibrosis is a dynamic process resulting from excessive deposition of extracellular matrix in the liver; uncontrolled progression of fibrosis can eventually lead to liver cirrhosis and/or hepatocellular carcinoma. The fibrogenic process is complex and modulated by a number of both hepatic and extra-hepatic biological factors. Growing evidence indicates that adipokines, a group of cytokines produced by adipose tissue, impart dynamic fibrosis. In particular, two key adipokines, adiponectin and leptin, directly regulate many biological responses closely associated with development and progression of hepatic fibrosis. Leptin acts as a pro-fibrogenic cytokine, while adiponectin possesses anti-fibrogenic and anti-inflamma-tory properties. Adiponectin, acting via its cognate recep-tors, adiponectin receptors 1 and 2, potently suppresses fibrosis and inflammation in liver via multiple mechanism. This review summarize recent findings concerning the role of adiponectin in fibrogenic process in liver and addresses the underlying molecular mechanisms in modu-lation of fibrosis.
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