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Primary cicatricial alopecia in South Korea : a 10-year nationwide cohort study
( Jisun Yoon ),( Byungwoo Soh ),( Jeewoong Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Primary cicatricial alopecia (PCA) is a stressful disorder for the affected patients and medically challenging for dermatologists. It is known to be uncommon, however, there is no large-scale study regarding the epidemiology of PCA. Objectives: To investigate the incidence, distribution of PCA subtypes, disease co-occurrence rates, and frequently prescribed medication of PCA. Methods: We investigated the National Health Insurance Service-National Sample Cohort for patients diagnosed with PCA according to the International Classification of Diseases. Annual and overall incidence rates and prevalence of PCA during the study period (2004-2013) were estimated. Results: The overall incidence was 6.10 (95% confidence interval, CI : 5.62 - 6.60) per 100,000 person-years. The incidence rate was stable over time (risk ratio, RR=1.012, p=0.201) and lower in female patients (RR=0.718, p<0.001). The overall prevalence was 20.93 (95% CI : 17.97 - 23.86) per 100,000 persons. TFolliculitis decalvans and dissecting cellulitis were the most common subtypes of PCA. PCA was significantly associated with thyroid disorders (age-sex adjusted odds ratio, OR=1.75, p<0.001), but not with dyslipidemia (age-sex adjusted OR=1.02, p=0.863). The most frequently prescribed medication was topical clobetasol and oral corticosteroids. Conclusion: Our study is the first study reporting the epidemiology of PCA on a large scale. We found predominance of male and neutrophil associated subtypes of PCA.