Palliative Radiotherapy in a Patient with Pulmonary Adenoid Cystic Carcinoma

BoKyong Kim 대한암학회 2007 Cancer Research and Treatment Vol.39 No.4

Primary adenoid cystic carcinoma in the lung is very rare, so its clinicopathologic characteristics have usually been extrapolated from the salivary disease. However, the clinical courses of pulmonary adenoid cystic carcinomas may be different from those of salivary disease, and individual differences may also exist. I report here on a case of a patient who was initially diagnosed as pulmonary adenoid cystic carcinoma with liver metastases and the tumor showed extreme radiosensitivity, but it also underwent an aggressive clinical course. Adenoid cystic carcinoma is usually known to be a slowly growing tumor, but it may rapidly disseminate, like in this patient. Therefore, the factors predicting aggressive behavior should be determined and the treatment might be individualized according to the primary sites and on the patient's basis. (Cancer Res Treat. 2007;39:185-188)

Development of the DVH management software for the biologically-guided evaluation of radiotherapy plan

BoKyong Kim,Hee Chul Park,Dongryul Oh,Eun Hyuk Shin,Yong Chan Ahn,Jinsung Kim,Youngyih Han 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.1

Purpose: To develop the dose volume histogram (DVH) management software which guides the evaluation of radiotherapy (RT) plan of a new case according to the biological consequences of the DVHs from the previously treated patients. Materials and Methods: We determined the radiation pneumonitis (RP) as an biological response parameter in order to develop DVH management software. We retrospectively reviewed the medical records of lung cancer patients treated with curative 3-dimensional conformal radiation therapy (3D-CRT). The biological event was defined as RP of the Radiation Therapy Oncology Group (RTOG) grade III or more. Results: The DVH management software consisted of three parts (pre-existing DVH database, graphical tool, and Pinnacle3 script). The pre-existing DVH data were retrieved from 128 patients. RP events were tagged to the specific DVH data through retrospective review of patients’ medical records. The graphical tool was developed to present the complication histogram derived from the preexisting database (DVH and RP) and was implemented into the radiation treatment planning (RTP) system, Pinnacle3 v8.0 (Phillips Healthcare). The software was designed for the pre-existing database to be updated easily by tagging the specific DVH data with the new incidence of RP events at the time of patients’ follow-up. Conclusion: We developed the DVH management software as an effective tool to incorporate the phenomenological consequences derived from the pre-existing database in the evaluation of a new RT plan. It can be used not only for lung cancer patients but also for the other disease site with different toxicity parameters.

Recent Development of Radiotherapy in Soft Tissue Sarcomas

BoKyong Kim 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3

Effect of melatonin feeding on growth and sexual development in young Nile tilapia, Oreochromis niloticus

Bokyong Kim,Jung-Hyun Kim,Jin Woo Park,Joon Yeong Kwon 한국발생생물학회 2011 한국발생생물학회 학술발표대회 Vol.30 No.-

Fish reproduction is influenced by various external environmental factors. Among these factors, changes of photic conditions are thought be most closely related to the reproduction of many fish species. In recent studies, melatonin that mediates the changes of photic condition outside has been used in an attempt to get a similar effect to photoperiod manipulation without changing photoperiod. However, the effects of exogenous melatonin vary depending on life stages. We have previously investigated the effect of melatonin on reproductive activity in mature Nile tilapia (Oreochromis niloticus). In this study, effects of exogenous melatonin on the spawning activity, the rate of mouth brooding success rate and early survival rate of lavae produced from melatonin treated Nile tilapia were investigated. Nile tilapia at the time of puberty were randomly divided into three groups and fed on control (0 ㎍/g), low-dose melatonin (2.5 ㎍/g BW) or high-dose melatonin (25 ㎍/g BW) diet. Fish were reared indoor tanks at 27~28℃ under natural-photoperiod and fed twice a day at 10:00 and16:00 during the experiment (120 days). Fish were sampled to examine growth and gonadal development on Day 30, 60, 90 and 120. There were no significant differences of somatic growth between control (no melatonin) and melatonin-treated groups, indicating that melatonin administration did not cause any negative effects on the growth of experimental fish. The patterns of gonadal development were almost the same between control and melatonin-treated groups. In juvenile tilapia, treatment with low-dose melatonin resulted in the increase of spawning rate, the rate of mouth brooding success and early survival rate of laval tilapia. However, high-dose melatonin resulted in the decrease of spawning rate, the rate of mouth brooding success and early survival rate of laval tilapia, although the earliest spawning occurred in one of the high-dose group fish. Fish in high-dose melatonin group failed to recover from reproductively suppressed state even after the cease of melatonin treatment, indicating that too much melatonin might act negatively on spawning activities and gonadal maturation in Nile tilapia. In conclusion, the results from this study suggest the possibility that a pertinent dose of melatonin treatment can effectively accelerate the spawning rate and the rate of mouth brooding success, and bring positive effects on early survival rate of tilapia lavae.

제 3의 신체를 그리는 공간 - 매튜 바니Matthew Barney의 Cremaster 4에 나타난 신체를 중심으로-

김보경 ( Kim Bokyong ) 부산대학교 여성연구소 2009 여성학연구 Vol.19 No.-

Post-structuralists consider human subject not a fixed category but a variable one formed socioculturally. Postmodern-feminists who have accepted postmodernism insist that if so, the feature of a gender which endows sexual feature is not fixed, either. They disapprove essential femininity and try to deconstruct both femininity as a fixed one and the paternal line society where it has been produced. They don't rely on sexual feature. So they don't call only female to account as a otherness in the paternal line society. They also regard male as a victim in the paternal line order. The common identity of a gender in both male and female is based on such recognition. The third gender that is presented refusing illusion of single identity is embodied with homosexuality, hermaphroditism, or both sexes. Matthew Barney has extended limitation of physical body to that of identity, and studied fundamental limitation of body. Matthew Barney developed his work of art with the mode of discourse Montage or ‘Montage sinifiant’. Discourse Montage is to make new fictitious world, making use of the form of discourse but not falling into the flowing. In the strange shape of body Matthew Barney created, ‘uncanny’, ‘grotesque’, and ‘abject’ is implied which are important notions of 1990s' body art. The variation of gender or the third gender Matthew Barney showed ruminates ‘postmodern human’ reality which is experiencing that crisis of body and identity. He repeats the conversion of ‘from male to female, then from female to male’, and so epistemological tension arrives at its culmination. In that process the horizon of ‘gender trouble’ is expanded out of the sphere of feminism.

Hepatitis B Virus Reactivation after Partial Hepatic Irradiation Alone

김보경(BoKyong Kim) 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2

B형 간염바이러스의 재활성화는 세포독성치료 및 면역억제치료를 시행 받은 만성 B형 간염 환자 및 보균자들에서잘 알려진 합병증이다. 방사선치료의 경우, B형 간염바이러스 재활성화에 대한 연구는 그 수가 적으며, 대개 이전에 항암화학요법 또는 경동맥화학색전술을 시행 받은 환자를 포함한다. 간의 방사선조사만을 시행 받은 환자에서의 B형 간염바이러스의 재활성화에 대한 연구는 보고된 바 없으며, 이에 본 증례를 보고한다. 본 연구를 통하여,간의 국소방사선조사 단독으로 B형 간염바이러스의 재활성화 유발의 가능성을 확인하였으며, 따라서, 간을 포함한 방사선조사 시 B형 간염관련 간질환 환자의 경우 방사선 관련 간질환뿐 아니라 바이러스의 재활성화에 대한 고려도 요구된다. Reactivation of the hepatitis B virus (HBV) is a well-recognized complication in patients with chronic HBV infection who receive cytotoxic or other immunosuppressive therapy. In cases of patients treated by radiotherapy however, only a few of such reports exist and most of these include the patients previously treated by chemotherapy or transarterial chemoembolization. The results of this study point to a case of a patient with reactivation of HBV after radiotherapy alone. This study shows the possibility of HBV reactivation by partial hepatic irradiation alone hence, special attention should be paid to patients with HBV disease.

The Effect of Day Length and Lunar Phases on the Spawning Activity in the Nile Tilapia Oreochromis niloticus

Jung-Hyun Kim,Bokyong Kim,Joon Yeong Kwon 한국수산과학회 양식분과 2010 한국수산과학회 양식분과 학술대회 Vol.2010 No.6

Changes of spawning activities by oral administration of melatonin in the Nile tilapia, Oreochromis niloticus

Jung-Hyun Kim,Bokyong Kim,Jinwoo Park,Joon Yeong Kwon 한국발생생물학회 2010 한국발생생물학회 학술발표대회 Vol.29 No.-

Photoperiod is known to be the most potent environmental stimulus for reproduction in many lower vertebrates, and it exerts an endogenous effect by causing a rhythmic change in melatonin level, which increases during the dark phase and decreases during the light phase. In recent studies, melatonin administration was capable of changing seasonal reproductive activities in several fish species, and also resulted in modulating the timing of smoltification in a salmonid fish (Amano et al., 2004; Ligo et al., 2005). In this study, we have investigated the changes of spawning activities (number of eggs, frequency of spawning) by oral administration of melatonin in the Nile tilapia, Oreochromis niloticus. Fish were obtained from a local fish farm (Chungju, Chung Buk) and acclimatized in fish rearing facilities in Sunmoon University (Asan, Chung Nam). Randomly selected 24 fishes (12 males, 12 females; 200~400 g in body weight, BW) were divided into three groups and each fish was accommodated into glass aquarium individually. Fish were fed either with control diet (0 ㎎ melatonin) or low-dose melatonin diet (0.3 ㎎ melatonin/㎏, BW) or high-dose melatonin diet (3 ㎎/㎏, BW). Fish were individually checked everyday for the presence of eggs in their mouths, and the eggs were removed and counted when found. Fish were fed twice a day, but melatonin treated diet was given only once a day at 10:00a.m.. The daily feeding ration was set at 2% of the body weight so that the fish ate all the pellets provided. Fish were sampled for blood parameters (Hb, Glu, GOT, GPT) on March 2 (Day 30), April 2 (Day 60), May 3 (Day 90), June 3 (Day 120) and July 14 (Day 160). The sampling was done between 14:00 and 16:00 p.m.. For the sampling, fish were anesthetized in 50 ppm benzocaine, and body length (BL) and BW were measured. Blood sample was collected using a heparinized syringe from the caudal blood vessel. Melatonin affects several photoperiodic signals including reproductive activities in fish. Low-dose melatonin administration appeared to disturb spawning and sexual maturation in Nile tilapia in this study. Fish treated with low-dose melatonin spawned less numbers of egg than the fish treated with high-dose. In contrast, high-dose melatonin administration caused more frequent spawning than low-dose melatonin. On the other hand, somatic growth and blood parameter were not affected by melatonin treatments. These results suggest that pertinent melatonin could be involved in providing photoperiodic information as short day photoperiod. Fish treated with over dose melatonin seemed to have no melatonin-free interval. In that circumstance the melatonin message might have not been conveyed as a proper signal.

Regulating Natural Lighting and Ventilation of Residential Buildings in Hong Kong Policy Implications for High-rise, High-density Housing Environments in South Korea

Bokyong Seo,Sung-Hwa Kim,Jae-Hoon Lee 대한건축학회 2014 Architectural research Vol.16 No.3

This study discusses the features of the lighting and ventilation regulations for residential buildings in Hong Kong. Given the compact built environment and public concerns about the environmental quality of housing, various lighting and ventilation regulations have been enacted in Hong Kong. The application of building regulations on the micro scale and incentive systems on the macro scale are present, and the governments’ calls for more active participation of the private sector and use of the building environmental assessment tools were also noted. Unlike South Korea, however, Hong Kong was found to adopt more performance-based standards, consider the external factors of the lighting and ventilation conditions together with the indoor elements, and provide specific design guidelines. Notwithstanding the different climatic conditions and socio-political contexts of Hong Kong and South Korea, these findings provide some policy implications for the South Korean government in its efforts to achieve a healthy environment for high-rise, high-density housing. It is suggested that the South Korean government adopt more on-site measurement methods to reflect the environmental conditions accurately and broaden the scope and scale of the implementation of the lighting and ventilation regulations with more specific, practical planning and design guidelines.

Regulating Natural Lighting and Ventilation of Residential Buildings in Hong Kong Policy Implications for High-rise, High-density Housing Environments in South Korea

Seo, Bokyong,Kim, Sung-Hwa,Lee, Jae-Hoon Architectural Institute of Korea 2014 Architectural research Vol.16 No.3

This study discusses the features of the lighting and ventilation regulations for residential buildings in Hong Kong. Given the compact built environment and public concerns about the environmental quality of housing, various lighting and ventilation regulations have been enacted in Hong Kong. The application of building regulations on the micro scale and incentive systems on the macro scale are present, and the governments' calls for more active participation of the private sector and use of the building environmental assessment tools were also noted. Unlike South Korea, however, Hong Kong was found to adopt more performance-based standards, consider the external factors of the lighting and ventilation conditions together with the indoor elements, and provide specific design guidelines. Notwithstanding the different climatic conditions and socio-political contexts of Hong Kong and South Korea, these findings provide some policy implications for the South Korean government in its efforts to achieve a healthy environment for high-rise, high-density housing. It is suggested that the South Korean government adopt more on-site measurement methods to reflect the environmental conditions accurately and broaden the scope and scale of the implementation of the lighting and ventilation regulations with more specific, practical planning and design guidelines.