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Reachability problem of state machines with batch processing arcs
Nami Mizuno,Atsushi Ohta,Kohkichi Tsuji 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
Petri net is an effective model for concurrent systems. Petri net with batch processing arcs, batch Petri net for short, is one of the Turing machine equivalent extended classes. Number of tokens moved by a firing of transition through the batch processing arcs equals to the minimum number of tokens among its input places connected with batch processing arcs, while fixed number of tokens are moved through normal arcs. This paper studies reachability problem of batch state machines, a subclass of batch Petri net. Its computational complexity is shown to be NP-hard. Sufficient conditions for reachability are derived based on classification of transitions.
Masahiro Yamazoe,Atsushi Mizuno,Yasuhiro Suyama,Yutaro Nishi,Koyu Suzuki,Koichiro Niwa,Masato Okada 대한심장학회 2014 Korean Circulation Journal Vol.44 No.6
A 36-year-old female with a high-grade fever and epigastric abdominal pain was prescribed antibiotics, but developed hypoxia and dyspnea. An echocardiography revealed diffuse hypokinesis and massive pericardial effusion, after which diagnostic cardiac catheterizationand an endomyocardial biopsy (EMB) were peformed to reveal fibrosis and infiltration of inflammation cells composed primarily of neutrophils. Clinical manifestation of a spiking fever, leukocytosis, elevated ferritin levels, skin rash and EMB findings led to a diagnosis of adultonsetStill’s disease (AOSD) with acute myocarditis. Pulse therapy of intravenous methylprednisolone was performed for three days, followedby a daily dose of prednisone (60 mg). After a course of steroid therapy for fever and pericardial effusion, and conducting a leftventricular ejection fraction, the patient showed improvement and was discharged asymptomatic within 32 days of admission. This studyis the first to report on a case of myocarditis in AOSD diagnosed by neutrophil infiltration in the myocardium.
Yano Yuichiro,Kanegae Hiroshi,Node Koichi,Mizuno Atsushi,Nishiyama Akira,Rakugi Hiromi,Itoh Hiroshi,Kitaoka Kaori,Kashihara Naoki,Ikeno Fumiaki,Tsuji Ichiro,Okada Kunio 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: Using a dataset from a survey on national health and productivity management, we identified health and productivity factors associated with organizational profitability. METHODS: The Ministry of Economy, Trade and Industry conducted an annual survey on Health and Productivity Management between 2014 and 2021. We assessed the associations of organizational health and productivity management using survey questions collected in 2017 and 2018, and the rate of change in profits from 2017 and 2018 to 2020. We identified factors associated with organizational profitability using eXtreme Gradient Boosting, and calculated SHapley Additive exPlanation (SHAP) values for each factor. RESULTS: Among 1,593 companies (n= 4,359,834 employees), the mean age for employees at baseline was 40.3 years and the proportion of women was 25.8%. The confusion matrix for evaluating model performance had accuracy of 0.997, precision of 0.993, recall of 0.997; and area under the precision-recall curve of 0.999. The most important factors related to an increase in corporate profits were the percentage of current smokers (SHAP value 0.121), per-employee cost for health services (0.084) and medical services (0.050); the percentage of full-time employees working in sales departments (0.074), distribution or customer service departments (0.054); the percentage of employees who sleep well (0.055); and the percentage of employees who have a habit of regular exercise within a company (0.043). CONCLUSIONS: The lifestyle health risk factors of employees and organizations’ management systems were associated with organizational profitability. Lifestyle medicine professionals may demonstrate a significant return on investment by creating a healthier and more productive workforce.
Yutaro Sasaki,Akiko Kojima-Yuasa,Hinako Tadano,Ayaka Mizuno,Atsushi Kon,Toshio Norikura 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.2
BACKGROUND/OBJECTIVES: Patients with chronic kidney disease (CKD) have a high concentration of uremic toxins in their blood and often experience muscle atrophy. Indoxyl sulfate (IS) is a uremic toxin produced by tryptophan metabolism. Although an elevated IS level may induce muscle dysfunction, the effect of IS on physiological concentration has not been elucidated. Additionally, the effects of ursolic acid (UA) on muscle hypertrophy have been reported in healthy models; however, it is unclear whether UA ameliorates muscle dysfunction associated with chronic diseases, such as CKD. Thus, this study aimed to investigate whether UA can improve the IS-induced impairment of mitochondrial biogenesis. MATERIALS/METHODS: C2C12 cells were incubated with or without IS (0.1 mM) and UA (1 or 2 μM) to elucidate the physiological effect of UA on CKD-related mitochondrial dysfunction and its related mechanisms using real-time reverse transcription-polymerase chain reaction, western blotting and enzyme-linked immunosorbent assay. RESULTS: IS suppressed the expression of differentiation marker genes without decreasing cell viability. IS decreased the mitochondrial DNA copy number and ATP levels by downregulating the genes pertaining to mitochondrial biogenesis (Ppargc1a, Nrf1, Tfam, Sirt1, and Mef2c), fusion (Mfn1 and Mfn2), oxidative phosphorylation (Cycs and Atp5b), and fatty acid oxidation (Pdk4, Acadm, Cpt1b, and Cd36). Furthermore, IS increased the intracellular mRNA and secretory protein levels of interleukin (IL)-6. Finally, UA ameliorated the IS-induced impairment in C2C12 cells. CONCLUSIONS: Our results indicated that UA improves the IS-induced impairment of mitochondrial biogenesis by affecting differentiation, ATP levels, and IL-6 secretion in C2C12 cells. Therefore, UA could be a novel therapeutic agent for CKD-induced muscle dysfunction.
Yasui, Takahiro,Tozawa, Keiichi,Ando, Ryosuke,Hamakawa, Takashi,Iwatsuki, Shoichiro,Taguchi, Kazumi,Kobayashi, Daichi,Naiki, Taku,Mizuno, Kentaro,Okada, Atsushi,Umemoto, Yukihiro,Kawai, Noriyasu,Sasak Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: To explore the safety, efficacy, and oncological outcome of 3-port laparoscopic radical cystectomy (LRC) compared to open radical cystectomy (ORC) in patients older than 75 years. Materials and Methods: From June 2010 to July 2014, we analyzed 16 radical cystectomies in patients older than 75 years (LRC group=8; ORC group=8). Demographic parameters, operative variables, and perioperative outcome in the 2 groups were retrospectively collected, analyzed, and compared. Results: Patients in both groups had comparable preoperative characteristics. A significantly longer operating time (476 vs. 303 min, P=0.0002) and less estimated blood loss (627 vs. 2,106 mL, P=0.021) were observed in the LRC group compared to the ORC group. Infection and ileus were the most common early complications after surgery. Patients who underwent ORC suffered from more postoperative infection (22.2% vs. 0.0%, P=0.054) and ileus (25.0% vs. 12.5%, P=0.521) than the LRC group, but the difference was not significant. Conclusions: Judging from this initial trial, 3-port LRC can be safely carried out in elderly patients. We suggest 3-port LRC as the primary intervention to treat muscle-invasive or high-risk nonmuscle-invasive bladder cancer in elderly patients with an otherwise relatively long life expectancy.